Abstract：
:Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human diseases. Here we review recent findings that implicate S-nitrosylation in cardiovascular, pulmonary, musculoskeletal and neurological (dys)function, as well as in cancer. The emerging picture shows that, in many cases, pathophysiology correlates with hypo- or hyper-S-nitrosylation of specific protein targets rather than a general cellular insult due to loss of or enhanced nitric oxide synthase activity. In addition, it is increasingly evident that dysregulated S-nitrosylation can not only result from alterations in the expression, compartmentalization and/or activity of nitric oxide synthases, but can also reflect a contribution from denitrosylases, including prominently the S-nitrosoglutathione (GSNO)-metabolizing enzyme GSNO reductase. Finally, because exogenous mediators of protein S-nitrosylation or denitrosylation can substantially affect the development or progression of disease, potential therapeutic agents that modulate S-nitrosylation could well have broad clinical utility.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Foster MW,Hess DT,Stamler JSdoi
10.1016/j.molmed.2009.06.007subject
Has Abstractpub_date
2009-09-01 00:00:00pages
391-404issue
9eissn
1471-4914issn
1471-499Xpii
S1471-4914(09)00119-1journal_volume
15pub_type
杂志文章,评审abstract：:Many infectious agents elicit a type I interferon response but, until recently, the molecular details that coordinate interferon (IFN)-alpha and -beta expression during infection were unknown. Innate immune pattern recognition receptors, including Toll-like receptors and cytoplasmic RNA helicases such as retinoic acid...
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2012-02-01 00:00:00
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更新日期：2014-09-01 00:00:00
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journal_title：Trends in molecular medicine
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更新日期：2006-12-01 00:00:00
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