Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes.

Abstract:

:Although significant progress has been made in understanding autoimmunity, no immunotherapy to effectively halt immune-mediated destruction of β cells in type 1 diabetes (T1D) is currently available. For successful immunotherapy it will be necessary to identify novel drug targets as well as robust immunologic biomarkers to predict disease heterogeneity and patient responsiveness. Inhibition of immune checkpoint mechanisms represents a novel and effective strategy in tumor immunotherapy. Because they are fundamental to rewiring immune circuits, the underlying mechanisms could be therapeutically enhanced and used as biomarkers in T1D. We examine here current knowledge of immune checkpoint molecules in T1D. One specific immune checkpoint mechanism, namely tryptophan metabolism, may meet the need for a valid drug target and robust biomarker in the quest for effective and personalized immunotherapy in T1D.

journal_name

Trends Mol Med

authors

Orabona C,Mondanelli G,Puccetti P,Grohmann U

doi

10.1016/j.molmed.2018.08.005

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

931-941

issue

11

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(18)30177-1

journal_volume

24

pub_type

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