Abstract：
:Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to irreversible joint damage, physical handicap, and reduced life expectancy. The past two decades have seen considerable therapeutic advances with the development of biologic treatments to block proinflammatory cytokines or modulate lymphocyte function, followed by the development of small molecules to target intracellular signaling. Nevertheless, only a minority of patients can achieve disease remission, especially long term, warranting further investigation into newer therapeutic options. Targeting single proinflammatory pathways may not be sufficient, as suggested by variable results with T helper (Th)-17-related cytokine blockade. Multilevel information from 'omics' techniques along with data from mechanistic studies might facilitate the identification of pivotal checkpoints in RA disease pathogenesis and the subsequent development of new effective treatments.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Semerano L,Minichiello E,Bessis N,Boissier MCdoi
10.1016/j.molmed.2016.01.005subject
Has Abstractpub_date
2016-03-01 00:00:00pages
214-229issue
3eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)00016-2journal_volume
22pub_type
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