Abstract：
:After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have been the focus of intense studies over the past decade. However, it is not yet known how to translate the features of bNAbs into practical HIV prevention methods. In this review, we attempt to seek insights from emerging information about the human broadly neutralizing plasma response as well as its frequency, clonal composition, specificity, potency, and commonality among infected subjects. We also consider how this information points to selecting and prioritizing certain epitope targets and strategies for HIV vaccine design.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Dashti A,DeVico AL,Lewis GK,Sajadi MMdoi
10.1016/j.molmed.2019.01.007subject
Has Abstractpub_date
2019-03-01 00:00:00pages
228-240issue
3eissn
1471-4914issn
1471-499Xpii
S1471-4914(19)30018-8journal_volume
25pub_type
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2003-02-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2014.10.006
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
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journal_title：Trends in molecular medicine
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更新日期：2002-07-01 00:00:00
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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journal_title：Trends in molecular medicine
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