Abstract:
:miRNAs are small noncoding RNAs known to post-transcriptionally regulate gene expression. miRNAs are expressed in the heart where they regulate multiple pathophysiological processes. The discovery of stable cardiac miRNAs in the bloodstream has also motivated the investigation of their potential as biomarkers. This review gathers the current knowledge on the use of miRNAs as novel biomarkers to improve risk stratification, diagnosis, and prognosis of patients with myocardial infarction. In the rapidly evolving era of biomarkers, the potential of miRNAs as promising tools to move personalized medicine a step forward is discussed.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Goretti E,Wagner DR,Devaux Ydoi
10.1016/j.molmed.2014.10.006subject
Has Abstractpub_date
2014-12-01 00:00:00pages
716-25issue
12eissn
1471-4914issn
1471-499Xpii
S1471-4914(14)00173-7journal_volume
20pub_type
杂志文章,评审abstract::H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel pe...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.10.006
更新日期:2005-12-01 00:00:00
abstract::MALT1 is a signaling protein that plays a key role in immunity, inflammation, and lymphoid malignancies. For a long time MALT1 was believed to function as a scaffold protein, providing an assembly platform for other signaling proteins. This view changed dramatically when MALT1 was also found to have proteolytic activi...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2005.02.003
更新日期:2005-04-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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更新日期:2011-02-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2018.02.001
更新日期:2018-04-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/s1471-4914(02)02276-1
更新日期:2002-02-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2010.09.002
更新日期:2010-11-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2006.07.003
更新日期:2006-09-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.11.007
更新日期:2006-01-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2008.05.002
更新日期:2008-07-01 00:00:00
abstract::A recent study introduced the existence of an 'immune clock' in pregnancy; during the course of gestation, peripheral blood cells from pregnant women were analyzed by mass cytometry using a single-cell signaling-based elastic net algorithm. The insights will undoubtedly promote the testing of such a clock - possibly i...
journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
doi:10.1016/j.molmed.2017.11.007
更新日期:2018-01-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2003.08.007
更新日期:2003-10-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2017.07.001
更新日期:2017-09-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2003.12.001
更新日期:2004-02-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.01.003
更新日期:2006-03-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.06.007
更新日期:2006-08-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/s1471-4914(00)01910-9
更新日期:2001-03-01 00:00:00
abstract::Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and polycystin-2, respectively. Optimizing the folding environment for polycystin-1 missense mutations may have a critical effect on the progression of ADPKD in animal models and could potentially lead t...
journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2016.10.001
更新日期:2016-12-01 00:00:00
abstract::Clinical medicine of the future is poised to use an individual's genomic data to predict disease risk and guide clinical care. The treatment of cigarette smoking and tobacco use disorder represents a prime area for genomics implementation. The genes CHRNA5 and CYP2A6 are strong genomic contributors that alter the risk...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2017.12.001
更新日期:2018-02-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2020.07.005
更新日期:2020-12-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 新闻
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2018.12.003
更新日期:2019-02-01 00:00:00
abstract::The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antim...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2016.09.003
更新日期:2016-11-01 00:00:00
abstract::After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have b...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2019.01.007
更新日期:2019-03-01 00:00:00
abstract::Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuro...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2018.11.005
更新日期:2019-02-01 00:00:00
abstract::Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal monogenic disorder, with more than 12 million cases worldwide. The two causative genes for ADPKD, PKD1 and PKD2, encode protein products polycystin-1 (PC1) and polycystin-2 (PC2 or TRPP2), respectively. Recent data have shed lig...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2014.01.004
更新日期:2014-05-01 00:00:00