Abstract：
:Mutations in whirlin, a putative PDZ scaffold protein, have recently been shown to cause deafness and short cochlear hair cell stereocilia in whirler mice and recessive deafness (DFNB31) in humans. Through its PDZ domains, whirlin might organize a group of proteins into a functional complex required for stereocilia elongation. Identifying these protein partners will advance our understanding of the development of stereocilia and their function as mechanosensory organelles indispensable for normal hearing.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Belyantseva IA,Labay V,Boger ET,Griffith AJ,Friedman TBdoi
10.1016/j.molmed.2003.09.008keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
458-61issue
11eissn
1471-4914issn
1471-499Xpii
S1471491403002156journal_volume
9pub_type
杂志文章abstract：:Hundreds of millions of people worldwide are affected by bone-related diseases, such as osteoporosis and rheumatoid arthritis. Understanding the molecular mechanisms of bone metabolism is crucial for developing novel drugs for treating such diseases. In particular, genetic experiments showing that the receptor activat...
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abstract：:Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) might contribute to β-cell dysfunction and disease. However, the mechanism of protein aggregation and associated toxicity remains unclear. Misf...
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abstract：:There is much evidence suggesting that there is a strong relationship between the deterioration of brain lipid homeostasis, vascular changes and the pathogenesis of Alzheimer's disease (AD). These associations include: (1). recognition that a key cholesterol transporter, apolipoprotein E type 4, acts a major genetic r...
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journal_title：Trends in molecular medicine
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更新日期：2015-10-01 00:00:00
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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abstract：:In a recent paper by Dvela-Levitt et al., chemical screening using an immunofluorescent assay identified a compound that caused removal of a dominant-inherited misfolded secretory protein, mucin1-frameshifted, from an intracellular location in immortalized renal epithelial cells of a patient affected with progressive ...
journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
abstract：:Accumulating evidence has revealed that immunogenic cell death triggered by particular chemotherapeutic agents plays a critical role in harnessing antitumor immunity to clinical responses. However, negative regulatory pathways exist which suppress the induction of effective immune responses by a broad spectrum of anti...
journal_title：Trends in molecular medicine
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abstract：:Carcinoma of the gastrointestinal tract is the most common internal malignancy affecting men and women in Western countries. Chronic intestinal inflammation, especially of the colon, is also a Western disease and correlates with a significantly increased risk of developing cancer. This has suggested that the immune pr...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/s1471-4914(01)02107-4
更新日期：2001-10-01 00:00:00
