Abstract：
:Small intestine bacterial overgrowth (SIBO) occurs when colonic quantities of commensal bacteria are present in the small bowel. SIBO is associated with conditions of disrupted gastrointestinal (GI) motility leading to stasis of luminal contents. Recent data show that SIBO is also found in children living in unsanitary conditions who do not have access to clean water. SIBO leads to impaired micronutrient absorption and increased GI permeability, both of which may contribute to growth stunting in children. SIBO also disrupts mucosal immunity and has been implicated in oral vaccination underperformance and the development of celiac disease. SIBO in the setting of the impoverished human habitats may be an under-recognized cause of pediatric morbidity and mortality in the developing world.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Donowitz JR,Petri WA Jrdoi
10.1016/j.molmed.2014.11.001subject
Has Abstractpub_date
2015-01-01 00:00:00pages
6-15issue
1eissn
1471-4914issn
1471-499Xpii
S1471-4914(14)00193-2journal_volume
21pub_type
杂志文章abstract：:In his article, Szyf [1] has addressed the key challenges in and the controversies surrounding nongenetic inheritance. However, crucial findings that are important to counter two major criticisms held against transgenerational inheritance, especially in mammals--namely epigenetic memory survival across generations, an...
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