Pediatric small intestine bacterial overgrowth in low-income countries.

Abstract:

:Small intestine bacterial overgrowth (SIBO) occurs when colonic quantities of commensal bacteria are present in the small bowel. SIBO is associated with conditions of disrupted gastrointestinal (GI) motility leading to stasis of luminal contents. Recent data show that SIBO is also found in children living in unsanitary conditions who do not have access to clean water. SIBO leads to impaired micronutrient absorption and increased GI permeability, both of which may contribute to growth stunting in children. SIBO also disrupts mucosal immunity and has been implicated in oral vaccination underperformance and the development of celiac disease. SIBO in the setting of the impoverished human habitats may be an under-recognized cause of pediatric morbidity and mortality in the developing world.

journal_name

Trends Mol Med

authors

Donowitz JR,Petri WA Jr

doi

10.1016/j.molmed.2014.11.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

6-15

issue

1

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(14)00193-2

journal_volume

21

pub_type

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