mTOR: A pathogenic signaling pathway in developmental brain malformations.

Abstract:

:The mTOR signaling network functions as a pivotal regulatory cascade during the development of the cerebral cortex. Aberrant hyperactivation of mTOR as a consequence of loss-of-function gene mutations encoding mTOR inhibitor proteins such as TSC1, TSC2, PTEN and STRADα has been recently linked to developmental cortical malformations associated with epilepsy and neurobehavioral disabilities. Investigation of mTOR signaling in these disorders provides for the first time exciting future avenues for assessment of biomarkers, patient stratification and prognostic measures as well as the opportunity for targeted therapy to regulate mTOR activity across all age groups. As we learn more about mTOR and its activity in the developing brain, many challenges will arise that must be overcome before widespread clinical therapeutics can be implemented.

journal_name

Trends Mol Med

authors

Crino PB

doi

10.1016/j.molmed.2011.07.008

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

734-42

issue

12

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(11)00141-9

journal_volume

17

pub_type

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