Abstract:
:The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
McLellan LK,Hunstad DAdoi
10.1016/j.molmed.2016.09.003subject
Has Abstractpub_date
2016-11-01 00:00:00pages
946-957issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)30118-6journal_volume
22pub_type
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