Developmental regulation of granule size and numbers in larval salivary glands of drosophila by steroid hormone ecdysone.

Abstract:

:The size and number of secretory granules in late larval salivary glands of Drosophila melanogaster have been related to interecdysial and early metamorphic development represented by well-known puffs in polytene chromosomes. Interecdysial period (puff stage 1 (PS1)) is characterized by presence of numerous small granules (11,000 per cell). The transition from PSI to early metamorphic phase (PS2 and upwards), induced by rapid elevation in endogenous steroid hormone ecdysone, is accompanied by continuous growth of granule diameter with concomitant reduction in their number per cell. In the PS4, just prior to secretion, approximately 3000 mature granules occur per cell. The mature state is associated with the change from hyperbolic to Gaussian distribution of granule number over their size range. Similar changes in secretory granule parameters were observed in interecdysial salivary glands explanted from 3rd instar larvae and cultured in vitro in medium containing 5x10(-6) m ecdysone.

journal_name

Cell Biol Int

authors

Farkas R,Suáková G

doi

10.1006/cbir.1999.0433

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

671-6

issue

10

eissn

1065-6995

issn

1095-8355

pii

S1065-6995(99)90433-X

journal_volume

23

pub_type

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