Abstract:
:Rb/E2F regulates many genes that encode proteins required for the cell cycle. Using affymetrix microarrays we previously identified genes regulated by the Rb proteins p130 and p107, many of which are involved in the cell cycle. Several genes with unknown functions were also repressed by p130 and p107, of which some have recently been found to have various roles in mitosis, the spindle checkpoint and cytokinesis. This study focuses on the regulation of borealin/dasra/cdca8, which encodes a recently discovered member of the chromosomal passenger complex. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Date DA,Jacob CJ,Bekier ME,Stiff AC,Jackson MW,Taylor WRdoi
10.1016/j.cellbi.2007.06.013subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1470-81issue
12eissn
1065-6995issn
1095-8355pii
S1065-6995(07)00185-0journal_volume
31pub_type
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