Abstract:
:This review summarizes the results of our investigations of actin unfolding-refolding and presents the notion that protein unfolding pathway, the number and the appearance order of intermediate states do not dependent on denaturing agents. To place our concept in the context of current knowledge of protein folding, we review in brief the development of general ideas of protein folding mechanisms, paying special attention to some key points of this process. Thus we focus on the characteristics of amino acid sequences that provide the existence of protein native structure, and on the interactions that compensate the increase of free energy due to the decrease of entropy on the way from multitude unfolded conformations to unique native state. In particular, we emphasize that ordered structures can arise both due to intramolecular and intermolecular interactions which lead to the formation of native and misfolded (associates, amorphous aggregates amyloid and amyloid-like fibrils) states, respectively.
journal_name
Cell Biol Intjournal_title
Cell biology internationalauthors
Povarova OI,Kuznetsova IM,Turoverov KKdoi
10.1016/j.cellbi.2007.01.025subject
Has Abstractpub_date
2007-04-01 00:00:00pages
405-12issue
4eissn
1065-6995issn
1095-8355pii
S1065-6995(07)00037-6journal_volume
31pub_type
杂志文章,评审abstract::In this paper the radioresistance of human erythrocytes to radiation-induced haemolysis was studied by means of the split-dose technique. Human erythrocytes suspended in an isotonic Na-phosphatase buffer, pH 7.4 were exposed under air to gamma radiation. Erythrocytes were irradiated with a single dose of 2.7 kGy and w...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1997.0188
更新日期:1997-09-01 00:00:00
abstract::We have studied the effect of enhanced expression of epithelial Na(+)channels (ENaC) on the ATP-induced Cl(-)secretion in the mouse epithelium using short-circuit current (I(SC)) and RT-PCR techniques. The amiloride sensitivity of basal current (I(b)) across the cultured endometrial epithelia was found to vary with th...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.2001.0754
更新日期:2001-01-01 00:00:00
abstract::Temperature of culture can be used to modulate cellular metabolism for improving small intestinal cell culture and cryopreservation. An hypothermia pretreatment (2 days at 25 degrees C and 3 hours recovery at 37 degrees C) improved hamster cell survival to freeze-thaw damage (p < 0.01) but decreased the survival of 2 ...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1994.1029
更新日期:1994-11-01 00:00:00
abstract::Under the 1G condition, the increase in antipain-sensitive protease activity promptly after UV (mainly 254 nm wavelength) irradiation in cultured human cells is detected and found to be one of the intriguing events involved in suppression of cell mutability. It was found that two cell lines, RSa and its variant UVAP-1...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/s1065-6995(02)00285-8
更新日期:2003-01-01 00:00:00
abstract::It has been proposed that cyclical gene expression occurs at a large number of different times during the cell cycle. The existence of a large number of cycle-specific variations in mRNA and protein during the eukaryotic cell cycle raises the problem of how cell-cycle variations are regulated. This is the "infinite re...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2008.10.004
更新日期:2009-01-01 00:00:00
abstract::The influence of maternal nicotine exposure during pregnancy and lactation on the Type II cells of lung tissue of one day old neonatal rat pups was investigated. The results clearly show that maternal nicotine exposure resulted in an increase in the type II cell count in the lungs of the offspring. In addition the lam...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1995.1075
更新日期:1995-04-01 00:00:00
abstract::Hyperglycemia is one of the most important pathogenesis of diabetic osteopathy. Several lines of studies indicate Runx2 plays a critical role in the process of osteogenic differentiation. However, little studies have analyzed the effect of Runx2 on osteoblast differentiation of rat bone mesenchymal stem cells (rBMSCs)...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.10779
更新日期:2017-08-01 00:00:00
abstract::Non-small-cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) was over-expressed in NSCLC tissues and cell lines. Overexpression of MAFG-AS1 promoted the migration, invasi...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11092
更新日期:2019-04-01 00:00:00
abstract::A structural link between cell's nucleus and centrosome was proposed years ago. Such a link was suggested to maintain nucleus-centrosome axis, determine polarity of interphase cells and ensure spindle assembly in mitotic cells. The idea of structural link is supported by the facts that centrosomes are usually located ...
journal_title:Cell biology international
pub_type: 杂志文章,评审
doi:10.1002/cbin.10016
更新日期:2013-02-01 00:00:00
abstract::Genistein is an isoflavone that has estrogen (E2 )-like activity and is beneficial for follicular development, but little is known regarding its function in oxidative stress (OS)-mediated granulosa cell (GC) injury. Here, we found that after exposure to H2 O2 , Genistein weakened the elevated levels of intracellular r...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11244
更新日期:2020-02-01 00:00:00
abstract::Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine. Initially upon transplantation, these cells home to and differentiate within the injured tissue into specialised cells. Contrariwise...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.10138
更新日期:2013-10-01 00:00:00
abstract::Mouse embryonic stem (ES) cells can be differentiated into neural lineage cells, but the differentiation efficiency remains low. This study revealed two important factors that influence the neural differentiation efficiency of mouse ES cells: the first is the quality of embryonic bodies (EBs); good quality of EBs cons...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2008.04.025
更新日期:2008-09-01 00:00:00
abstract::Ro52/SSA is an autoantigen that presents in patients with SS (Sjögren's syndrome) and SLE (systemic lupus erythematosus). It increases cell death and redistributes itself to apoptotic blebs, but its pro-apoptotic function has not been completely identified. Overexpression of Ro52/SSA promoted cell apoptosis induced by...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1042/CBI20110322
更新日期:2012-05-01 00:00:00
abstract::Cadherins, being responsible for selective cell recognition and normal tissue integrity in adults, regulate morphogenesis in a variety of organs during development. In this study, anti-rat pan-cadherin antibody, specific to all subgroups of the cadherin family, was used to map the distribution of the pan-cadherin immu...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.2002.0956
更新日期:2002-01-01 00:00:00
abstract::Growth hormone (GH), given therapeutically in many human diseases, is able to modulate the maturation and function of many cells of immune system. The present study demonstrates the effect of human recombinant GH on the production of acute phase proteins (APP) as well as on the gene expression of junB proto-oncogene o...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1999.0454
更新日期:2000-01-01 00:00:00
abstract::We analyzed whether the embryonic (E12.5-E14.5) mouse retina possesses genuine neural stem cells and how they respond to defined growth factors and extracellular matrix molecules. Whereas most combinations produced no or limited cell survival and proliferation in culture, FGF-2 plus heparin and laminin stimulated prol...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2006.11.031
更新日期:2007-07-01 00:00:00
abstract::Adipose tissue is a potential site of retinoic acid (RA) action, but its physiological significance remains to be clarified. We have examined the effect of all-trans retinoic acid (ATRA) on growth and differentiation of preadipocytes, and on adipokine gene expression in mature adipocytes using human preadipocyte cell ...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.10005
更新日期:2013-01-01 00:00:00
abstract::microRNAs (miRNAs) have recently been recognized as playing an important role in bone-associated diseases. This study investigated whether the reduced miR-155-5p in steroid-associated osteonecrosis of the femoral head (ONFH) attenuated osteogenic differentiation and cell proliferation by targeting GSK3B. Bone marrow w...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11470
更新日期:2021-01-01 00:00:00
abstract::The effects of cadmium Cd (II) ions on the physiology and biological activity of Trametes versicolor, a strain belonging to white-rotting Basidiomycetes, were examined. Cd (II) ions were added to 10-day-old cultures grown on a liquid medium, or at the time of inoculation. Our experiments showed that T. versicolor is a...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.2002.0887
更新日期:2002-01-01 00:00:00
abstract::The epidermal keratinocytes express two major pairs of keratin polypeptides. One pair (K5/K14) expressed specifically in basal generative compartment and the other (K1/K10) expressed specifically in the differentiating suprabasal compartment. The switch in the expression of the keratins from proliferating to different...
journal_title:Cell biology international
pub_type: 杂志文章,评审
doi:
更新日期:1996-04-01 00:00:00
abstract::The spatial distribution of acid membrane organelles and their relationships with normal and vacuolated transverse tubules has been studied in living frog skeletal muscle fibres using confocal microscopy. Acridine orange (AO) was used to evaluate acid compartments, while a lipophilic styryl dye, RH 414, was employed t...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1016/j.cellbi.2006.06.017
更新日期:2006-11-01 00:00:00
abstract::Physical forces play a critical role in cell integrity and development, but little is known how cells convert mechanical signals into biochemical responses. This mini-review examines potential molecular mediators like integrins, focal adhesion proteins, and the cytoskeleton in the context of a complex cell structure. ...
journal_title:Cell biology international
pub_type: 杂志文章,评审
doi:10.1006/cbir.2002.0857
更新日期:2002-01-01 00:00:00
abstract::Glycometabolism, particularly mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis, plays a central role in cell life activities. Glycometabolism can be reprogrammed to maintain the stemness or to induce the differentiation of stem cells, thereby regulating tissue repair and regeneration. However, research ...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.10568
更新日期:2016-03-01 00:00:00
abstract::Osteosarcoma (OS) is the most common type of primary bone tumor that exhibits invasive growth and long-distance organ metastasis. Thus, investigating the specifically targeted therapeutic agents against metastatic osteosarcoma depends on understanding the molecular mechanisms. The long noncoding RNAs (lncRNA) XIST (X-...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11405
更新日期:2020-10-01 00:00:00
abstract::The mitogenic effect of TGF-alpha, acidic-FGF, basic-FGF and lithium on normal human breast epithelial cells was studied in a collagen gel culture system using a serum-free 1:1 mixture of Ham's F12 and DME medium containing insulin, cholera toxin and bovine serum albumin. TGF-alpha elicited a strong mitogenic response...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1006/cbir.1993.1077
更新日期:1993-04-01 00:00:00
abstract::Accurate relative gene expression analysis by reverse transcription-quantitative polymerase chain reaction relies on the usage of suitable reference genes for data normalization. The RNA content of small extracellular vesicles including exosomes is growingly considered as cancer biomarkers. So, reliable relative quant...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11556
更新日期:2021-01-27 00:00:00
abstract::Our study aimed to explore the function of cystic fibrosis transmembrane conductance regulator (CFTR) in esophageal cancer. Twenty patients with esophageal squamous cell carcinoma (ESCC) and 20 patients with esophageal adenocarcinoma (EA) were enrolled in this study. The levels of CFTR and NF-κB in tumor tissues and a...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11069
更新日期:2018-12-01 00:00:00
abstract::With rapid development of space engineering, research on life sciences in space is being conducted extensively, especially cellular and molecular studies on space medicine. Stem cells, undifferentiated cells that can differentiate into specialized cells, are considered a key resource for regenerative medicine. Researc...
journal_title:Cell biology international
pub_type: 杂志文章,评审
doi:10.1002/cbin.10452
更新日期:2015-06-01 00:00:00
abstract::Periodontitis is a chronic inflammatory disease that results in the destruction of periodontal soft tissue and the resorption of alveolar bone. Evidence indicates that in diabetic patients, hyperglycemia suppresses periodontal ligament stem cell (PDLSC) functions and leads to difficulties in periodontal repair. The pr...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.11445
更新日期:2020-12-01 00:00:00
abstract::Adaptation of cardiomyocytes to chronic hypoxia in cyanotic patients remains unclear. Mitochondrial biogenesis is enhanced in myocardium from cyanotic patients, which is possibly an adaptive response. Erythropoietin (EPO) in blood and its receptor (EPOR) on cardiomyocytes are upregulated by chronic hypoxia, suggesting...
journal_title:Cell biology international
pub_type: 杂志文章
doi:10.1002/cbin.10205
更新日期:2014-03-01 00:00:00