LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.

abstract：:Insulin resistance (IR) is a hallmark of type 2 diabetes mellitus (T2DM). This study aimed to explore the effects of rapamycin, a specific inhibitor of kinase mammalian target of rapamycin (mTOR), on IR in T2DM rats, and to validate whether the underlying mechanism was associated with autophagy. In this study, the mod...

journal_title：Cell biology international

authors： Zhou W,Ye S

更新日期：2018-09-01 00:00:00

abstract：:Epigenetic silencing of cancer-related genes by abnormal methylation and the reversal of this process by DNA methylation inhibitors represents a promising strategy in cancer therapy. As DNA methylation affects gene expression and chromatin structure, we investigated the effects of novel DNMT (DNA methyltransferase) in...

journal_title：Cell biology international

authors： Savickiene J,Treigyte G,Jazdauskaite A,Borutinskaite VV,Navakauskiene R

更新日期：2012-11-01 00:00:00

abstract：:A plant transformation and selection system has been developed utilizing a modified tubulin gene as a selectable marker. The vector constructs carrying a mutant alpha-tubulin gene from goosegrass conferring resistance to dinitroaniline herbicides were created for transformation of monocotyledonous and dicotyledonous p...

journal_title：Cell biology international

authors： Yemets A,Radchuk V,Bayer O,Bayer G,Pakhomov A,Vance Baird W,Blume YB

更新日期：2008-05-01 00:00:00

abstract：:Lysosomal permeability to potassium ions is an important property of the organelle. Influence of the membrane physical state on the potassium ion permeability of isolated lysosomes was assessed by measuring the membrane potential with bis(3-propyl-5-oxoisoxazol-4-yl)pentamethine oxonol and monitoring the lysosomal pro...

journal_title：Cell biology international

authors： Wang J,Zhang GJ

更新日期：2005-06-01 00:00:00

abstract：:Transcriptional regulation and binding interactions between soluble nucleoproteins and the hormone response elements (REs) of the rat haptoglobin (Hp) and alpha 2-macroglobulin (alpha 2MG) genes was examined in the livers of rats during the acute-phase reaction. Our results demonstrate that the elevation of the Hp and...

journal_title：Cell biology international

authors： Petrović M,Bogojević D,Grigorov I,Sevaljević L

更新日期：1995-12-01 00:00:00

abstract：:A line of evidences have validated that multiple microRNAs (including miR-16, miR-483 and miR-324-3p) were abnormally expressed in granulosa cells, which may be closely related with the pathogenesis of polycystic ovary syndrome (PCOS). Long-chain non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1...

journal_title：Cell biology international

authors： Sang X,Zhang Y

更新日期：2020-03-28 00:00:00

abstract：:The induction and maintenance of immunologic tolerance at the feto-maternal interface is necessary for a successful pregnancy. The most accepted hypothesis for the mechanism underlying this tolerance is that pregnancy-induced foetal antigen-specific maternal T regulatory (T(reg) ) cells mediate maternal tolerance to t...

journal_title：Cell biology international

authors： Hao K,Zhou Q,Chen W,Jia W,Zheng J,Kang J,Wang K,Duan T

更新日期：2013-02-01 00:00:00

abstract：:Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine. Initially upon transplantation, these cells home to and differentiate within the injured tissue into specialised cells. Contrariwise...

journal_title：Cell biology international

authors： Jayaraman P,Nathan P,Vasanthan P,Musa S,Govindasamy V

更新日期：2013-10-01 00:00:00

abstract：:ES (embryonic stem)-derived cells have been investigated in many animal models of severe injury and degenerative disease. However, few studies have examined the ability of ES-derived cells to improve functional outcome following partially damaged breast and also the modification of mammary tissue to produce costly pro...

journal_title：Cell biology international

authors： Huang HJ,Gao QS,Qian YG,Zhang YD,Tao BF,Xiang M,Peng J,Jiang SW,Hause B

更新日期：2010-10-01 00:00:00

abstract：:MSCs (mesenchymal stem cells) are planned foruse in regenerative medicine to offset age-dependent alterations. However, MSCs are affected by replicative senescence associated with decreasing proliferation potential, telomere shortening and DNA damage during in vitro propagation. To monitor in vitro senescence, we have...

journal_title：Cell biology international

authors： Fuchs R,Stelzer I,Drees CM,Rehnolt C,Schraml E,Sadjak A,Schwinger W

更新日期：2012-01-01 00:00:00

abstract：:A structural link between cell's nucleus and centrosome was proposed years ago. Such a link was suggested to maintain nucleus-centrosome axis, determine polarity of interphase cells and ensure spindle assembly in mitotic cells. The idea of structural link is supported by the facts that centrosomes are usually located ...

journal_title：Cell biology international

authors： Burakov AV,Nadezhdina ES

更新日期：2013-02-01 00:00:00

abstract：:Accurate relative gene expression analysis by reverse transcription-quantitative polymerase chain reaction relies on the usage of suitable reference genes for data normalization. The RNA content of small extracellular vesicles including exosomes is growingly considered as cancer biomarkers. So, reliable relative quant...

journal_title：Cell biology international

authors： Gorji-Bahri G,Moradtabrizi N,Vakhshiteh F,Hashemi A

更新日期：2021-01-27 00:00:00

abstract：:Rosbin (Thieno [2, 3-c] piperidine-3-carboxamide-2-[(3-methoxy-naphtha-lene-2-carbonyl)-amino]-6-(benzyl)-, hydrochloride), a synthetic piperidinothieno derivative compound obtained from chemical genetics screenings, significantly suppresses the viability of non-small cell lung cancer A549 cells with an IC50 of 2.05 ±...

journal_title：Cell biology international

authors： Zhao T,Jin W,Pan H,Li H,Zhao Y,Feng Y

更新日期：2017-02-01 00:00:00

abstract：:The mitogenic effect of TGF-alpha, acidic-FGF, basic-FGF and lithium on normal human breast epithelial cells was studied in a collagen gel culture system using a serum-free 1:1 mixture of Ham's F12 and DME medium containing insulin, cholera toxin and bovine serum albumin. TGF-alpha elicited a strong mitogenic response...

journal_title：Cell biology international

authors： Sakthivel R,Hamdan M,Yang J,Guzman RC,Nandi S

更新日期：1993-04-01 00:00:00

abstract：:Osteocalcin is one of the most abundant non-collagenous proteins in bone that is commonly used as a preliminary biomarker in bone formation. Osteocalcin also regulates energy metabolism as a hormone. Estrogen-related receptor alpha (ERRα) is primarily thought to regulate energy homeostasis through interacting with per...

journal_title：Cell biology international

authors： Wang H,Wang J

更新日期：2013-11-01 00:00:00

abstract：:Coumarin and its derivative 7-hydroxycoumarin (7-OHC) have antitumor and antimetastatic properties. The purpose of this study was to investigate the possible effects of these compounds on expression of the bcl-2 and Bax oncoproteins in two human lung cancer cell lines, A427 and Calu-1. The cells were cultured in vitro...

journal_title：Cell biology international

authors： Elinos-Báez CM,León F,Santos E

更新日期：2005-08-01 00:00:00

abstract：:Inostamycin, which was recently isolated from Streptomyces sp. MH816-AF15 as an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, caused a G1-phase accumulation in the cell cycle of small cell lung carcinomas. To investigate whether the cytostatic effect of inostamycin is rest...

journal_title：Cell biology international

authors： Baba Y,Tsukuda M,Mochimatsu I,Furukawa S,Kagata H,Nagashima Y,Koshika S,Imoto M,Kato Y

更新日期：2001-01-01 00:00:00

abstract：:Receptor-interacting serine/threonine kinase 4 (RIPK4) and transforming growth factor-β 1 (TGF-β1) play critical roles in the development and maintenance of the epidermis. A negative correlation between the expression patterns of RIPK4 and TGF-β signaling during epidermal homeostasis-related events and suppression of ...

journal_title：Cell biology international

authors： Dinçer T,Boz Er AB,Er İ,Toraman B,Yildiz G,Kalay E

更新日期：2020-03-01 00:00:00

abstract：:The purpose of the study was to examine the effect of interleukins, IL-6, IL-8, and IL-15, on insulin-mediated redistribution of Rab4a, an early endosome marker, in mouse 3T3-L1 adipocytes. The interleukins did not affect cell viability; however, cell number was slightly but significantly higher in cultures exposed to...

journal_title：Cell biology international

authors： Błaszczyk M,Gajewska M,Milewska M,Grzelkowska-Kowalczyk K

更新日期：2017-04-01 00:00:00

abstract：:It has been proposed that cyclical gene expression occurs at a large number of different times during the cell cycle. The existence of a large number of cycle-specific variations in mRNA and protein during the eukaryotic cell cycle raises the problem of how cell-cycle variations are regulated. This is the "infinite re...

journal_title：Cell biology international

authors： Cooper S,Shedden K,Vu-Phan D

更新日期：2009-01-01 00:00:00

abstract：:We analyzed whether the embryonic (E12.5-E14.5) mouse retina possesses genuine neural stem cells and how they respond to defined growth factors and extracellular matrix molecules. Whereas most combinations produced no or limited cell survival and proliferation in culture, FGF-2 plus heparin and laminin stimulated prol...

journal_title：Cell biology international

authors： Otaegi G,de Pablo F,Vicario-Abejón C,de la Rosa EJ

更新日期：2007-07-01 00:00:00

abstract：:Physical forces play a critical role in cell integrity and development, but little is known how cells convert mechanical signals into biochemical responses. This mini-review examines potential molecular mediators like integrins, focal adhesion proteins, and the cytoskeleton in the context of a complex cell structure. ...

journal_title：Cell biology international

authors： Goldmann WH

更新日期：2002-01-01 00:00:00

abstract：:Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry from extracellu...

journal_title：Cell biology international

authors： Ogata Y,Nakao S,Shimizu E,Matsuda-Honjyo Y,Yamazaki M,Furuyama S,Sugiya H

更新日期：2003-01-01 00:00:00

abstract：:This review summarizes original and literature data on changes in the ultrastructure of major cell organelles during apoptosis obtained by transmission electron microscopy. Organelles that make the most crucial contribution to the initiation of apoptosis: plasma membrane, mitochondria, proteasomes, Golgi apparatus, an...

journal_title：Cell biology international

authors： Snigirevskaya ES,Komissarchik YY

更新日期：2019-07-01 00:00:00

abstract：:A method based on the measurement at room temperature of tryptophan phosphorescence (RTTP) gives the unique possibility to investigate the dynamic structure of membrane proteins without their isolation from cells. This method was used to study the influence of tert- butyl hydroperoxide (t -BHP) on Chinese hamster fibr...

journal_title：Cell biology international

authors： Mazhul V,Shcherbin D,Zavodnik I,Rekawiecka K,Bryszewska M

更新日期：1999-01-01 00:00:00

abstract：:It has been demonstrated that the crude extract of mosquito larvae alters the mitotic rate of several mouse cell populations of young growing mice (25 +/- 1 days old). Furthermore, the dialysed fraction of the extract inhibited proliferation of hepatocytes from hepatectomized adult male mice (90 days old). Sampling du...

journal_title：Cell biology international

authors： Ronderos JR,Riccillo FL,Ottino A

更新日期：1996-08-01 00:00:00

abstract：:Investigation of the relative slowness with which trypsin detaches epithelial cells from their adhesions with a substratum suggests that the adherent surface of the cells is normally rather inaccessible to the enzyme. Trypsinisation of cells through a porous filter allowing access of the enzyme to the underside of the...

journal_title：Cell biology international

authors： Simpson K,McGrath M,Curtis A

更新日期：1993-03-01 00:00:00

abstract：:The effect of hypoxia on the differentiation of chronic myeloid leukaemic K562 cells were studied, as was the role of the NHE1 (Na+/H+ exchanger 1). Hypoxia induced differentiation of K562 cells as seen by modifications in their morphological features, up-regulation of C/EBPα (CCAAT/enhancer-binding protein α), and ma...

journal_title：Cell biology international

authors： Jin W,Li Q,Wang J,Chang G,Lin Y,Li H,Wang L,Gao W,Pang T

更新日期：2012-08-01 00:00:00

abstract：:Glycometabolism, particularly mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis, plays a central role in cell life activities. Glycometabolism can be reprogrammed to maintain the stemness or to induce the differentiation of stem cells, thereby regulating tissue repair and regeneration. However, research ...

journal_title：Cell biology international

authors： Wang L,Cheng L,Wang H,Pan H,Yang H,Shao M,Hu T

更新日期：2016-03-01 00:00:00

abstract：:The Kv2.1 potassium channel is a principal component of the delayed rectifier I(K) current in the pyramidal neurons of cortex and hippocampus. We used whole-cell patch-clamp recording techniques to systemically compare the electrophysiological properties between the native neuronal I(K) current of cultured rat hippoca...

journal_title：Cell biology international

authors： Liu M,Gong B,Qi Z

更新日期：2008-12-01 00:00:00