Analysis of allele segregation distortion in a swine resource family.

Abstract:

:Segregation distortion of alleles was found in several regions of the genome in allele type analyses of genetic markers for a swine resource family that had been constructed by crossing Göttingen miniature pig and Meishan breeds. From these regions, a region on chromosome 6 presented a distortion over several consecutive markers. This chromosome 6 region was subsequently further investigated to reveal that alleles of a chromosome 6 homologue of the Gottingen miniature pig were not found in a homozygous family member. The litter size of F1-crosses which were able to produce homozygotes in this region were 24% smaller, on average, than F1-crosses which were unable to produce homozygotes. This indicated that this region of the chromosome 6 homologue contained a recessive gene or genes which could terminate fetal development. An additional 10 markers were subsequently used to investigate the region more precisely. These studies revealed that this region spans 7 cM and is located between markers Sw855 and Sw122. Since current comparative maps show that this region corresponds to the human chromosome 19 q-arm, genes positioned on the human chromosome 19 q-arm were screened to select 20 candidate genes. These included the pregnancy-specific beta-1-glycoprotein gene.

journal_name

Anim Biotechnol

journal_title

Animal biotechnology

authors

Yasue H,Mikawa S,Uenishi H,Wada Y

doi

10.1080/10495399909525939

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

147-52

issue

3

eissn

1049-5398

issn

1532-2378

journal_volume

10

pub_type

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