Novel polymorphism of HSP70 gene affected caprine physiological vital parameters.

Abstract:

:The synthesis of heat shock protein 70 (HSP70) is temperature-dependent and its response is considered as a cellular thermometer in response to thermal stress. The variation in HSP70 gene expression has been positively correlated with thermo-tolerance. Three different goat populations (Black Bengal, Ganjam and Raighar) which differ in body size, coat color and production performance were assessed for effect of thermal stress at different temperature humidity index (THI). The physiological vital parameters like rectal temperature (RT), skin temperature (ST), heart rate (HR) and respiration rate (RR) which are related to thermal stress susceptibility were recorded. The genetic variation of HSP70 gene in the three goat populations and its effect on physiological vital parameters related to thermal stress was assessed. A novel polymorphism (C241T) in the exonic region of HSP70 gene with significant (p < .05) statistical association with the physiological vital parameters like RT, ST and RR was identified indicating its role in thermo-tolerance.HighlightsThe HSP70 gene was found to be polymorphic in Indian goats.The non-synonymous nucleotide change (C241T) resulted change in amino acid Arginine 241 Cysteine in mature polypeptide which were not reported earlier.The constructed phylogenetic tree showed that Ganjam and Raighar goats are more close to each other.

journal_name

Anim Biotechnol

journal_title

Animal biotechnology

authors

Mohalik PK,Sahoo SS,Mishra C,Dash SK,Nayak G

doi

10.1080/10495398.2020.1726364

subject

Has Abstract

pub_date

2020-02-12 00:00:00

pages

1-8

eissn

1049-5398

issn

1532-2378

pub_type

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