Abstract:
:In pigs, susceptibility to enterotoxigenic Escherichia coli (ETEC) K88 strains (locus F4bcR) is determined by a dominant allele, with the recessive allele determining resistance. The susceptible allele also appeared to be associated with higher growth rate even with discordant results. A single nucleotide polymorphism (SNP) in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify susceptible pigs, substituting invasive villous adhesion tests. We herein analyzed this SNP in Italian local breeds and applied a selective genotyping approach in Italian Large White, Italian Landrace, and Italian Duroc comparing allele frequency distribution in groups of pigs with extreme estimated breeding values (EBV) for average daily gain (ADG) and backfat thickness (BFT) to evaluate if this marker is associated with these traits. Allele G (associated with susceptibility to ETEC) was associated with higher ADG and BFT in Italian Large White (P=6.66E-04 and P=0.012, respectively) and higher ADG in Italian Landrace (P=7.23E-12). This polymorphism was poorly informative in Italian Duroc. Antagonistic associations of the MUC4 g.8227C>G alleles on susceptibility to ETEC and growth performances evidence the complexity of applying marker assisted selection in pig breeding.
journal_name
Anim Biotechnoljournal_title
Animal biotechnologyauthors
Fontanesi L,Bertolini F,Dall'Olio S,Buttazzoni L,Gallo M,Russo Vdoi
10.1080/10495398.2011.653462subject
Has Abstractpub_date
2012-01-01 00:00:00pages
147-55issue
3eissn
1049-5398issn
1532-2378journal_volume
23pub_type
杂志文章abstract::We assessed SLC27A1, a candidate gene for milk production traits in Chinese Holstein cattle. DNA was extracted from the blood of 48 top Chinese Holstein Cattle selected according to phenotypic character and mixed into DNA pool for SNP detection. We tested blood samples of these cattle for SNPs in exon 3 and the 3'-fla...
journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2011.527567
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/10495390500461104
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doi:10.1080/10495398.2019.1616554
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2010.490693
更新日期:2010-07-01 00:00:00
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journal_title:Animal biotechnology
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doi:10.1080/10495398.2019.1622555
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abstract::This study elucidated the molecular markers that decrease oocyte quality during in vitro culture, restricting optimal developmental potential. Here, we evaluated the transcriptomic differences between cysteamine-treated and non-treated bovine cumulus oocyte complexes (COCs) after 22 h of co-culture in the maturation m...
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doi:10.1080/10495398.2019.1706545
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journal_title:Animal biotechnology
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doi:10.1080/10495398.2016.1242490
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doi:10.1080/10495398.2020.1732397
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doi:10.1080/10495398.2020.1735404
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doi:10.1080/10495398.2019.1640717
更新日期:2019-07-18 00:00:00
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journal_title:Animal biotechnology
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doi:10.1080/10495398.2020.1740240
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2017.1313269
更新日期:2018-04-03 00:00:00
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2012.742909
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doi:10.1080/10495390802212445
更新日期:2008-01-01 00:00:00
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doi:10.1080/10495398.2020.1824920
更新日期:2021-01-18 00:00:00
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journal_title:Animal biotechnology
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更新日期:2012-04-01 00:00:00
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journal_title:Animal biotechnology
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doi:10.1080/10495399809525887
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495390802340923
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2011.559562
更新日期:2011-04-01 00:00:00
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1080/10495398.2011.630897
更新日期:2012-01-01 00:00:00
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更新日期:2018-04-03 00:00:00
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journal_title:Animal biotechnology
pub_type: 杂志文章
doi:10.1081/ABIO-120026481
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更新日期:2021-01-24 00:00:00