Abstract:
:CARP, ANKRD2, and DARP belong to the ankyrin repeat protein (MARP) family and play a critical role in the integration of cytoskeletal architecture, stress response, and transcriptional regulation. In this study, we cloned the cDNA and promoter sequences of porcine ankyrin repeat protein (MARP) gene family. RT-PCR analysis revealed that porcine CARP gene was predominantly expressed in heart. ANKRD2 was widely expressed in many tissues, a high expression level was observed in the skeletal muscle and heart. DARP gene was expressed specifically in skeletal muscle and heart. Moreover, the expression of CARP and ANKRD2 was significantly different in porcine skeletal muscle among different developmental stages and between the two breeds. Expression analysis in porcine satellite cells showed that CARP and ANKRD2 were induced in differentiated porcine satellite cells, suggesting a role of them in myogenic differentiation. This result suggests that the MARP gene family may be important genes for skeletal muscle growth and provides useful information for further studies on their roles in porcine skeletal muscle.
journal_name
Anim Biotechnoljournal_title
Animal biotechnologyauthors
Wang L,Lei M,Xiong Ydoi
10.1080/10495398.2011.559562subject
Has Abstractpub_date
2011-04-01 00:00:00pages
87-99issue
2eissn
1049-5398issn
1532-2378pii
936504399journal_volume
22pub_type
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