Abstract:
:The aim of this study was to investigate genes for differential expression in cartilage of foals predisposed to osteochondrosis (OC). Tissue was sampled from the cranial part of the distal intermediate ridge of the tibia in the tarso-crural joint. Foals were considered predisposed to OC when parents had OC at the distal intermediate ridge of the tibia. RNA was isolated and subjected to arbitrarily primed PCR (RAP-PCR) followed by fingerprinting to screen for differentially expressed genes. By verification of results from the RAP-PCR fingerprint screening using real-time RT-PCR, we identified two genes not previously correlated with OC as differentially expressed. The two genes, which were identical to TLK2 and an equine EST, are good targets for future research on OC.
journal_name
Anim Biotechnoljournal_title
Animal biotechnologyauthors
Austbø L,Røed KH,Dolvik NI,Skretting Gdoi
10.1080/10495391003608316subject
Has Abstractpub_date
2010-04-01 00:00:00pages
135-9issue
2eissn
1049-5398issn
1532-2378pii
920998023journal_volume
21pub_type
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