当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF LEGAL MEDICINE期刊下所有文献 > Higher detection rate of hepatitis G and C virus RNA in liver tissue than in serum of deceased injection drug users.

Higher detection rate of hepatitis G and C virus RNA in liver tissue than in serum of deceased injection drug users.

Abstract：

:To examine the prevalence of hepatitis G virus (HGV) and hepatitis C virus (HCV) infections in deceased injection drug users and for comparison of the detection rates of HGV and HCV RNA in liver tissue with detection rates in postmortem serum samples, RT-PCR was performed in 50 drug abuse-related fatalities. HGV RNA was detectable in liver tissue samples from 17/50 suddenly deceased drug abusers (34%). In 16 of these 17 positive cases, serum samples were also available but HGV RNA was detected in only 10. From 29/50 anti-HCV positive individuals, HCV RNA was detected in 23/50 liver tissue samples (46%), but HCV RNA was detectable in only 6/22 of the corresponding serum samples. In 12 anti-HCV positive cases (10 being also positive for HCV RNA in the liver), the examinations revealed a coinfection with HGV by detection of HGV RNA in the liver tissue samples. A significant association between the detection of HCV RNA in the liver and the occurrence of antibodies against the HCV NS4 protein, but not against HCV core antigen or NS3 protein was observed. The probability of anti-HCV and HCV RNA positivity increased with the age of the individuals. No HGV or HCV infection was detected in a control group of 50 persons who died suddenly by violent impact. The prevalence of active HCV and HGV infections in injection drug users detected by RT-PCR in liver tissue is in good accordance with data obtained from sera from living injection drug users. In contrast, the detection rate in postmortem serum samples was clearly lower. Possible reasons for this observation are discussed and the use of liver tissue for postmortem detection of hepatitis virus RNA is recommended.

journal_name

Int J Legal Med

journal_title

International journal of legal medicine

authors

Seidl S,Koenig B,Reinhardt G,Hampl W,Mertens T,Michel D

doi

10.1007/s004140050195

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

35-8

issue

1

eissn

0937-9827

issn

1437-1596

journal_volume

112

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF LEGAL MEDICINE文献大全
  • Distribution of artifactual gas on post-mortem multidetector computed tomography (MDCT).

    abstract：PURPOSE:We investigated the incidence and distribution of post-mortem gas detected with multidetector computed tomography (MDCT) to identify factors that could distinguish artifactual gas from cardiac air embolism. MATERIAL AND METHODS:MDCT data of 119 cadavers were retrospectively examined. Gas was semiquantitatively...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-010-0542-5

    authors： Egger C,Bize P,Vaucher P,Mosimann P,Schneider B,Dominguez A,Meuli R,Mangin P,Grabherr S

    更新日期：2012-01-01 00:00:00

  • Population genetic analysis of the Globalfiler STR loci in 3032 individuals from the Altay Han population of Xinjiang in northwest China.

    abstract：:The genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci included in the GlobalFiler™ PCR Amplification Kit were evaluated in 3032 unrelated individuals Altay Han of Xinjiang, northwest China. All of the loci reached the Hardy-Weinberg equilibrium. These loci were examined to determine allele frequenci...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1641-3

    authors： Li X,Li L,Wang Q,Zhang J,Ge W,Bai R,Yu X,Shi M

    更新日期：2018-01-01 00:00:00

  • Neuropathological studies in the brains of AIDS patients with opportunistic diseases.

    abstract：:The brains of 70 fatal cases with AIDS were studied by means of immunohistochemistry and in-situ hybridization in a consecutive autopsy series (1985-July 1992). In addition, the neuropathological changes were correlated with the neurological and neuroimaging findings. Opportunistic infections included toxoplasmosis (1...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01222119

    authors： Neuen-Jacob E,Figge C,Arendt G,Wendtland B,Jacob B,Wechsler W

    更新日期：1993-01-01 00:00:00

  • Concentrations of cyanide in blood samples of corpses after smoke inhalation of varying origin.

    abstract：:Cyanide (CN) blood concentration is hardly considered during routine when evaluating smoke gas intoxications and fire victims, although some inflammable materials release a considerable amount of hydrogen cyanide. CN can be significant for the capacity to act and can in the end even be the cause of death. Systematic d...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-016-1426-0

    authors： Stoll S,Roider G,Keil W

    更新日期：2017-01-01 00:00:00

  • Impact of DNA degradation on massively parallel sequencing-based autosomal STR, iiSNP, and mitochondrial DNA typing systems.

    abstract：:Biological samples, including skeletal remains exposed to environmental insults for extended periods of time, exhibit increasing levels of DNA damage and fragmentation. Human forensic identification methods typically use a combination of mitochondrial (mt) DNA sequencing and short tandem repeat (STR) analysis, which t...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-019-02110-4

    authors： Zavala EI,Rajagopal S,Perry GH,Kruzic I,Bašić Ž,Parsons TJ,Holland MM

    更新日期：2019-09-01 00:00:00

  • Paradoxical undressing associated with subarachnoid hemorrhage in a non-hypothermia case?

    abstract：:Paradoxical undressing is a phenomenon characterizing some fatal hypothermia cases. The victims, despite low environmental temperatures, paradoxically remove their clothes due to a sudden feeling of warmth. In this report, we describe a case of suspected paradoxical undressing in a non-hypothermia case. The victim, a ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1597-3

    authors： Descloux E,Ducrot K,Scarpelli MP,Lobrinus A,Palmiere C

    更新日期：2017-09-01 00:00:00

  • Multiple methods used for type detection of uniparental disomy in paternity testing.

    abstract：:Uniparental disomy (UPD) has attracted more attention recently in paternity testing, though it is an infrequent genetic event. Although short tandem repeat (STR) profiling has been widely used in paternity testing, it is not sufficient to use STR only to judge the genetic relationship, because the existence of UPD wil...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-019-02215-w

    authors： Su H,Sun T,Chen M,Liu J,Wang X,Chen Y,Ren W,Zhang G,Yan J,Yun K

    更新日期：2020-05-01 00:00:00

  • The use of the STRs HUMTH01, HUMVWA31/A, HUMF13A1, HUMFES/FPS, HUMLPL in forensic application: validation studies and population data for Galicia (NW Spain).

    abstract：:The 5 tetranucleotide short tandem repeats, HUMTH01, HUMVWA31/A, HUMF13A1, HUMFES/FPS and HUMLPL were studied using different electrophoretic methods and PCR amplification conditions in order to optimize the typing conditions. A genetic population study in the population of Galicia was carried out and the allele and g...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01246874

    authors： Pestoni C,Lareu MV,Rodríguez MS,Muñoz I,Barros F,Carracedo A

    更新日期：1995-01-01 00:00:00

  • Genetic diagnosis of acute aortic dissection in South China Han population using next-generation sequencing.

    abstract：:Acute aortic dissection (AAD) is a clinically "silent," but emergent and life-threatening cardiovascular disease, and hereditary factors play an important etiologic role in the development of AAD. The purposes of this study are to definitize the diagnostic yield of 59 AAD patients, investigate the molecular pathologic...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-018-1890-9

    authors： Zheng J,Guo J,Huang L,Wu Q,Yin K,Wang L,Zhang T,Quan L,Zhao Q,Cheng J

    更新日期：2018-09-01 00:00:00

  • The pharmacology and toxicology of kratom: from traditional herb to drug of abuse.

    abstract：:Mitragyna speciosa (Rubiaceae), commonly known as kratom, is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. In recent years, kratom has gained popularity for use as a recreational drug across the globe. Relatively new to the illicit market and used in a manner different f...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00414-015-1279-y

    authors： Warner ML,Kaufman NC,Grundmann O

    更新日期：2016-01-01 00:00:00

  • Identification of forensically important Sarcophaga species (Diptera: Sarcophagidae) using the mitochondrial COI gene.

    abstract：:The identification of species of the forensically important genus Sarcophaga is very difficult and requires strong taxonomic expertise. In this study, we sequenced the mitochondrial cytochrome c oxidase subunit I (COI) gene of 126 specimens of 56 W European Sarcophaga species and added GenBank data to our database to ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-012-0767-6

    authors： Jordaens K,Sonet G,Richet R,Dupont E,Braet Y,Desmyter S

    更新日期：2013-03-01 00:00:00

  • Cuts to the offender's own hand--unintentional self-infliction in the course of knife attacks.

    abstract：:In a knife attack the perpetrator can unintentionally injure his own hand, if the knife does not have an adequate handguard and the tip of the blade hits a solid, mostly bony structure while being violently thrust into the victim's body. The injuries occurring under these conditions are localized on the flexor side of...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-004-0491-y

    authors： Schmidt U,Faller-Marquardt M,Tatschner T,Walter K,Pollak S

    更新日期：2004-12-01 00:00:00

  • Development of two multiplex PCR systems for the analysis of 14 X-chromosomal STR loci in a southern Brazilian population sample.

    abstract：:We developed two multiplex systems for the coamplification of X-chromosomal short tandem repeats (STRs). X-Multiplex 1 consisted of DXS6807, DXS6800, DXS7424, DXS101, GATA172D05 and HPRTB and X-Multiplex 2 consisted of DXS8378, DXS9898, DXS6801, DXS6809, DXS6789, DXS7133, DXS8377 and DXS7423. In addition, we present a...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-011-0629-7

    authors： Penna LS,Silva FG,Salim PH,Ewald G,Jobim M,Magalhães JA,Jobim LF

    更新日期：2012-03-01 00:00:00

  • Racemization in enamel among different types of teeth from the same individual.

    abstract：:We measured the quantity of D-aspartic acid (degree of racemization of aspartic acid) in the enamel of different types of teeth from the same individual. We studied the correlation between the degree of racemization and the time of formation of each particular tooth, as well as the applicability of the degree of racem...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-004-0506-8

    authors： Ohtani S,Ito R,Arany S,Yamamoto T

    更新日期：2005-03-01 00:00:00

  • The use of post-mortem computed tomography in the investigation of intentional neonatal upper airway obstruction: an illustrated case.

    abstract：:We present a single case report illustrating the diagnostic role of multi-slice computed tomography (MSCT) in the investigation of suspicious child death where mechanical asphyxia is suspected. The case illustrates how radiological findings that may not be observable on conventional plain X-ray were identified by post...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-010-0438-4

    authors： Rutty GN,Jeffery AJ,Raj V,Morgan B

    更新日期：2010-11-01 00:00:00

  • The genetic evidence for human origin of Jivaroan shrunken heads in collections from the Polish museums.

    abstract：:Advances in forensic identification using molecular genetics are helpful in resolving some historical mysteries. The aim of this study was to confirm the authenticity of shrunken-head artifacts exhibited by two Polish museums. Shrunken heads, known as tsantsas, were headhunting trophies of South American Indians (Jiva...

    journal_title：International journal of legal medicine

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00414-016-1448-7

    authors： Piniewska D,Sanak M,Wojtas M,Polanska N

    更新日期：2017-05-01 00:00:00

  • Variants of the melanocortin 1 receptor gene (MC1R) and P gene as indicators of the population origin of an individual.

    abstract：:The population origin of an individual is often requested to be determined from specimens left at a crime scene for identifying a suspect and individual identity. The melanocortin 1 receptor gene (MC1R) and P gene are associated with human pigmentation. Although several studies have reported that these genes are highl...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-008-0289-4

    authors： Masui S,Nakatome M,Matoba R

    更新日期：2009-05-01 00:00:00

  • Different types of structural variation in STRs: HumFES/FPS, HumVWA and HumD21S11.

    abstract：:Alleles of the STR systems HumFES/FPS, HumVWA and HumD21S11 were sequenced and analyzed. Sequence data revealed 3 different systems concerning the complexity of their sequence structure. HumFES/FPS belongs to the STR polymorphism with a simple repeat structure. Only 2 subtypes were found with a base substitution in th...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01224779

    authors： Möller A,Meyer E,Brinkmann B

    更新日期：1994-01-01 00:00:00

  • Intravenous methadone application as a serious risk factor for an overdose death: methadone-related fatalities in Hamburg from 2007 to 2012.

    abstract：:Methadone plays an increasing role in drug-related deaths in Hamburg. To find out whether intravenous application of methadone plays a relevant role in methadone-related deaths, body fluids of all methadone-positive cases (n=130) and three buprenorphine-positive cases where a urine sample was available (n=58+3) were i...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-014-1017-x

    authors： Iwersen-Bergmann S,Jungen H,Andresen-Streichert H,Müller A,Elakkary S,Püschel K,Heinemann A

    更新日期：2014-09-01 00:00:00

  • Superimposition technique for skull identification with Afloat® software.

    abstract：:The craniofacial superimposition technique is still an important way of identifying skulls when there is no reference sample for a forensic DNA analysis, when DNA typing from remaining tissue samples has failed, or when antemortem dental records are not available. Through the widespread use of digital photography, the...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-010-0494-9

    authors： Birngruber CG,Kreutz K,Ramsthaler F,Krähahn J,Verhoff MA

    更新日期：2010-09-01 00:00:00

  • Sudden unexpected death in childhood due to eosinophilic myocarditis.

    abstract：:A 12-year-old boy with no previous serious medical history experienced abdominal discomfort and chest pains for 5 days and suddenly died. The autopsy revealed diffuse and extensive infiltration of eosinophils into the myocardium, with poorly formed granulomas and few fibrotic changes. The necrotic changes was so exten...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01369797

    authors： Aoki Y,Nata M,Hashiyada M,Sagisaka K

    更新日期：1996-01-01 00:00:00

  • Stability of carbohydrate deficient transferrin (CDT) in stored blood samples.

    abstract：:The alcoholism marker CDT was determined on 257 blood samples 1-2 days after the blood samples were taken and again after storage for 7 months at +4 degrees C. The differences between the pairs of CDT values were so large that the determination of CDT after long term storage of the blood sample has no evidential value...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050013

    authors： Köhler H,West A,Brinkmann B

    更新日期：2000-01-01 00:00:00

  • Poisonous or non-poisonous plants? DNA-based tools and applications for accurate identification.

    abstract：:Plant exposures are among the most frequently reported cases to poison control centres worldwide. This is a growing condition due to recent societal trends oriented towards the consumption of wild plants as food, cosmetics, or medicine. At least three general causes of plant poisoning can be identified: plant misident...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00414-016-1460-y

    authors： Mezzasalma V,Ganopoulos I,Galimberti A,Cornara L,Ferri E,Labra M

    更新日期：2017-01-01 00:00:00

  • Identifying novel microhaplotypes for ancestry inference.

    abstract：:The use of DNA to determine the ancestry of an individual is becoming more and more important in the areas of forensics. Kidd et al. (Forensic Sci Int Genet 12:215-224, 2014) have been the first to identify and catalog haplotypes, termed as minihaplotypes (1-10-kilobase spans) and microhaplotypes (≤ 200 bp), with pote...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-018-1881-x

    authors： Chen P,Zhu W,Tong F,Pu Y,Yu Y,Huang S,Li Z,Zhang L,Liang W,Chen F

    更新日期：2019-07-01 00:00:00

  • Y-chromosomal STR haplotypes and their applications to forensic and population studies in east Asia.

    abstract：:We have analyzed 11 Y-STR loci (DYS19, the two DYS385 loci, DYS388, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DXYS156Y) in 700 males from ten ethnic groups in east Asia in order to evaluate their usefulness for forensic and population genetic studies. A total of 644 different haplotypes were identified, among which ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-004-0518-4

    authors： Kwak KD,Jin HJ,Shin DJ,Kim JM,Roewer L,Krawczak M,Tyler-Smith C,Kim W

    更新日期：2005-07-01 00:00:00

  • Influence of dose-death interval on colchicine and metabolite distribution in decomposed skeletal tissues.

    abstract：:The semi-quantitative analysis of decomposed bone of rats exposed to colchicine and euthanized following different time intervals postexposure (i.e., dose-death interval, DDI) is described. Rats received colchicine (50 mg/kg, i.p.) and were euthanized 30 min (DDI1; n = 4), 60 min (DDI2; n = 4), or 180 min (DDI3; n = 4...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-015-1196-0

    authors： Imfeld AB,Watterson JH

    更新日期：2016-03-01 00:00:00

  • A dangerous design for a mountain bike.

    abstract：:The case of a man's death as a consequence of an accident with a mountain bike was examined. Despite only slight external injuries, a general examination revealed the existence of a rupture of the diaphragm which was the ultimate cause of death. The discussion reconstructs the way the accident occurred and briefly ana...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140100237

    authors： Alvarez-Segui M,Castello-Ponce A,Verdu-Pascual F

    更新日期：2001-12-01 00:00:00

  • Sequence variation of a hypervariable short tandem repeat at the D1S1656 locus.

    abstract：:A short tandem repeat at the D1S1656 locus was sequenced in 45 selected alleles and 13 different alleles were found which were designated according to the total number of repeats. This STR is a compound hypervariable STR consisting of blocks of (TAGR) repeats with a basic sequence structure (TAGA)4(TGA)0-1(TAGA)6-16(T...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050161

    authors： Lareu MV,Barral S,Salas A,Pestoni C,Carracedo A

    更新日期：1998-01-01 00:00:00

  • Examining the socioeconomic effects on third molar maturation in a Portuguese sample of children, adolescents and young adults.

    abstract：INTRODUCTION:The impact of socioeconomic status (SES) on tooth mineralization has seldom been evaluated. This is important because SES can be used as a proxy for quantifying factors in the environmental that can impact mineralization but that can be difficult to measure directly, such as nutrition. OBJECTIVE:The objec...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-016-1476-3

    authors： Carneiro JL,Caldas IM,Afonso A,Cardoso HF

    更新日期：2017-01-01 00:00:00

  • Genomic portrait of population of Jharkhand, India, drawn with 15 autosomal STRs and 17 Y-STRs.

    abstract：:We analysed 15 autosomal STRs in 200 unrelated individuals (102 males and 98 females) and 17 Y-STRs in 102 unrelated males living in Jharkhand, India, to establish parameters of forensic interest. The examined autosomal STRs revealed high combined power of exclusion (CPE) and combined power of discrimination (CPD) as ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1610-x

    authors： Imam J,Reyaz R,Singh RS,Bapuly AK,Shrivastava P

    更新日期：2018-01-01 00:00:00