当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF LEGAL MEDICINE期刊下所有文献 > Variants of the melanocortin 1 receptor gene (MC1R) and P gene as indicators of the population origin of an individual.

Variants of the melanocortin 1 receptor gene (MC1R) and P gene as indicators of the population origin of an individual.

Abstract：

:The population origin of an individual is often requested to be determined from specimens left at a crime scene for identifying a suspect and individual identity. The melanocortin 1 receptor gene (MC1R) and P gene are associated with human pigmentation. Although several studies have reported that these genes are highly polymorphic in human populations, it is unclear if the allele variants can be used to determine the population origin of an individual. We aimed to determine the ethnic origin of an individual by using single nucleotide polymorphisms (SNPs). Eighteen SNPs in the MC1R gene and P genes were genotyped in 52 individuals by the direct sequencing method, and 4 SNPs (MC1R gene: R163Q and P gene: IVS5 + 1001, IVS13 + 113, and H615R) were selected on the basis of differences in frequencies. Subsequently, we genotyped these four SNPs in 422 volunteers from six ethnically defined populations using a polymerase chain reaction-based assay. The results revealed that the allele variants were present with high frequencies in Asian populations but were low in European and African populations. On the basis of these results, we defined a specific combination of a genotype (R163Q) and a diplotype group (IVS5 + 1001, IVS13 + 113, and H615R). This study indicates that the specific combination of a genotype and a diplotype group would be effective in estimating the population origin of an individual from a list of population groups.

journal_name

Int J Legal Med

journal_title

International journal of legal medicine

authors

Masui S,Nakatome M,Matoba R

doi

10.1007/s00414-008-0289-4

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

205-11

issue

3

eissn

0937-9827

issn

1437-1596

journal_volume

123

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF LEGAL MEDICINE文献大全
  • Biomechanical stress in myocardial infarctions: can endothelin-1 and growth differentiation factor 15 serve as immunohistochemical markers?

    abstract：:Myocardial infarctions go along with biomechanical stress, i.e. stretching of muscle fibres, and the expression of certain marker molecules. We tested if two of those markers, endothelin-1 (ET-1) and growth differentiation factor 15 (GDF-15), can be used as immunohistochemical markers for myocardial ischaemia/infarcti...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1726-z

    authors： Falk M,Huhn R,Behmenburg F,Ritz-Timme S,Mayer F

    更新日期：2018-03-01 00:00:00

  • The application of mitochondrial DNA typing to the study of white Caucasian genetic identification.

    abstract：:Mitochondrial DNA (mtDNA) from 100 unrelated British White Caucasians was extracted, amplified and directly sequenced. Sequences of approximately 800 nucleotides were obtained from 2 hypervariable segments within the non-coding region of the mitochondrial genome. A total of 91 different sequences were observed with an...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01225046

    authors： Piercy R,Sullivan KM,Benson N,Gill P

    更新日期：1993-01-01 00:00:00

  • Fatal intoxication by intravenous injection of castor bean (Ricinus communis L.) extract-a case study.

    abstract：:A case report of a 25-year-old man who committed suicide by intravenous injection himself of an aqueous home-made castor bean extract is presented. The patient was hospitalized and treated symptomatically and was released at its own request fourth day after intoxication. The next day, the patient's condition deteriora...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-020-02340-x

    authors： Staňková M,Handlos P,Švidrnoch M,Maier V

    更新日期：2020-11-01 00:00:00

  • delta-Storage pool disease: a pitfall in the forensic investigation of sudden anal blood loss in children: a case report.

    abstract：:We present the case of a 3.5-year-old boy with sudden anal blood loss at school. Sexual abuse was suspected, and, apart from anal fissures seen on sigmoidoscopy, no other clinical signs of any sort of disorder were present. As no medical explanation for the blood loss could be given, penetrating anal trauma was sugges...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00414-005-0053-y

    authors： De Munnynck K,Van Geet C,De Vos R,Van de Voorde W

    更新日期：2007-01-01 00:00:00

  • Blood species discrimination using proton nuclear magnetic resonance spectroscopy.

    abstract：:Blood species identification is an important challenge in forensic science. Conventional methods used for blood species analysis are destructive and associated with time-consuming sample preparation steps. Nuclear magnetic resonance (NMR) spectroscopy is known for its nondestructive properties and fast results. This r...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-016-1500-7

    authors： Zailer E,Diehl BW,Monakhova YB

    更新日期：2017-05-01 00:00:00

  • Biostatistical evaluation of blood group, HLA and DNA findings in Jeffreys' immigrant test-case using special kinship and DNA algorithms.

    abstract：:In the immigration case cited by Jeffreys et al. (1985), the biostatistical evaluation of blood group findings in 16 systems and of HLA-A,B findings for the mother and child, using a special kinship algorithm developed by Ihm and Hummel (1975), produced a probability of maternity of the Ghanaian-born putative mother o...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01371238

    authors： Hummel K

    更新日期：1992-01-01 00:00:00

  • Sex determination from buccal mucosa scrapes.

    abstract：:Establishing individuality is an imperative aspect in any investigation procedure. At times, it becomes necessary to determine the sex of the individual to establish identity, and saliva stains found at the scene of crime are of major help in such cases. In the present study, we have determined the sex of the individu...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-008-0285-8

    authors： Mittal T,Saralaya KM,Kuruvilla A,Achary C

    更新日期：2009-09-01 00:00:00

  • Phylogenetic classification of Japanese mtDNA assisted by complete mitochondrial DNA sequences.

    abstract：:We investigated control and coding region polymorphisms in mitochondrial DNA (mtDNA) in 100 unrelated individuals from a Japanese population and determined the basal phylogenetic haplogroup lineages in all samples under updated information. Many of the basal phylogenetic haplogroup lineages assigned on East Asian mtDN...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-008-0308-5

    authors： Nohira C,Maruyama S,Minaguchi K

    更新日期：2010-01-01 00:00:00

  • Postmortem interrogation of cardiac implantable electrical devices may clarify time and cause of death.

    abstract：BACKGROUND:Postmortem interrogation of cardiac implantable electrical devices (CIED) in autopsy is not routinely performed. Thus, it remains unclear whether an interrogation might clarify time and cause of death. METHODS:Seventy of 4401 patients (1.6%) undergoing autopsy in 2014 and 2015 presented with a CIED. The exp...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-018-1932-3

    authors： Riesinger L,Fichtner S,Schuhmann CG,Estner HL,Czermak T,Graw M,Fischer F,Lackermair K

    更新日期：2019-05-01 00:00:00

  • Detainees in police custody in the Paris, France area: medical data and high-risk situations (a prospective study over 1 year).

    abstract：BACKGROUND AND OBJECTIVE:The annual number of detainees held in police custody in France is approximately 700,000. Medical data regarding arrestees are scarce across countries. We present the medical characteristics of detainees kept in police custody, including addictive behaviours and high-risk medical situations. M...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-014-0990-4

    authors： Chariot P,Beaufrère A,Denis C,Dang C,Vincent R,Boraud C

    更新日期：2014-09-01 00:00:00

  • A new technique for the postmortem detection of tooth-coloured dental restorations.

    abstract：:Identification of unknown bodies is mainly made by dental examination and comparison with accurate dental records. Therefore it is necessary to examine the jaws carefully and to locate every tooth-coloured dental restoration. Overlooking dental fillings can make positive identification impossible. The technique descri...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050138

    authors： Benthaus S,DuChesne A,Brinkmann B

    更新日期：1998-01-01 00:00:00

  • Histomorphological analysis of the variability of the human skeleton: forensic implications.

    abstract：:One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be propose...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-018-1781-0

    authors： Cummaudo M,Cappella A,Biraghi M,Raffone C,Màrquez-Grant N,Cattaneo C

    更新日期：2018-09-01 00:00:00

  • Sudden unexpected death in childhood due to eosinophilic myocarditis.

    abstract：:A 12-year-old boy with no previous serious medical history experienced abdominal discomfort and chest pains for 5 days and suddenly died. The autopsy revealed diffuse and extensive infiltration of eosinophils into the myocardium, with poorly formed granulomas and few fibrotic changes. The necrotic changes was so exten...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01369797

    authors： Aoki Y,Nata M,Hashiyada M,Sagisaka K

    更新日期：1996-01-01 00:00:00

  • Radiographic evaluation of Gustafson's criteria for the purpose of forensic age diagnostics.

    abstract：:The main criteria used in dental age estimation in living young individuals are mineralisation and eruption of the third molars. In order to further diversify the spectrum of characteristics after completion of third molar development, tests were undertaken to determine whether the characteristics studied by Gustafson...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-012-0701-y

    authors： Olze A,Hertel J,Schulz R,Wierer T,Schmeling A

    更新日期：2012-07-01 00:00:00

  • An unusual observation of tetragametic chimerism: forensic aspects.

    abstract：:A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. Mixed fields with anti-B and anti-A+B antisera led to the conclusion that blood group B and 0 cell populations were present in a 1:1 ratio...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-009-0332-0

    authors： Verdiani S,Bonsignore A,Casarino L,Ferrari GM,Zia SC,De Stefano F

    更新日期：2009-09-01 00:00:00

  • Factors affecting accuracy and precision of thermal summation models of insect development used to estimate post-mortem intervals.

    abstract：:This paper investigates the effects that different summary statistics (minimum, median, mean, or maximum), temporal sampling resolutions (duration between sampling events), and sample sizes (number of individuals sampled per sampling event) had on the accuracy and precision of the regression coefficients of a typical ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-008-0243-5

    authors： Richards CS,Villet MH

    更新日期：2008-09-01 00:00:00

  • The pharmacology and toxicology of kratom: from traditional herb to drug of abuse.

    abstract：:Mitragyna speciosa (Rubiaceae), commonly known as kratom, is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. In recent years, kratom has gained popularity for use as a recreational drug across the globe. Relatively new to the illicit market and used in a manner different f...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章,评审

    doi：10.1007/s00414-015-1279-y

    authors： Warner ML,Kaufman NC,Grundmann O

    更新日期：2016-01-01 00:00:00

  • Further sequence and length variation at the STR loci HumFES/FPS, HumVWA, HumFGA and D12S391.

    abstract：:This paper reports population data and statistics for the HumFES/FPS, HumVWA, HumFGA and D12S391 loci in Austria. The sequences of some rare and new variant alleles which have been identified in the course of the present population study and other investigations are described. Sequence variation occurred in a HumFES/F...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/pl00007712

    authors： Dauber EM,Glock B,Schwartz DW,Mayr WR

    更新日期：2000-01-01 00:00:00

  • Proficiency testing for psychoactive substances in Italy.

    abstract：:This paper describes the general design and main results of the Italian proficiency testing program for the analysis of psychoactive substances in urine, a long-term initiative created in 1995 on an educational basis and characterized by an innovative internet-based service for data exchange between laboratories and t...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050279

    authors： Ferrara SD,Brusini G,Maietti S,Frison G,Castagna F,Allevi S,Menegus AM,Tedeschi L

    更新日期：1999-01-01 00:00:00

  • 58 cases of sexual violence bearing forensic interest: congruence between the victim's report and the data from laboratory analyses.

    abstract：:The assistance provided by specialised healthcare personnel to victims of a sexual violence cannot focus just on the clinical intervention appropriate for the lesions suffered by the patient, but must also take legal and forensic needs into account. Anamnestic data represents a crucial step towards the finding of fore...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1602-x

    authors： Gino S,Canavese A,Pattarino B,Robino C,Omedei M,Albanese E,Castagna P

    更新日期：2017-09-01 00:00:00

  • The application of dental methods of identification to human burn victims in a mass disaster.

    abstract：:This paper deals with the usefulness of dental identification in the case of 28 human burn victims of a bus accident in Spain. Postmortem forensic procedures for identification were used including general external examination, routine photographs and radiographs and complementary biological methods. Dental identificat...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004149900099

    authors： Valenzuela A,Martin-de las Heras S,Marques T,Exposito N,Bohoyo JM

    更新日期：2000-01-01 00:00:00

  • A study on the short tandem repeat system ACTBP2 (SE33) in an Austrian population sample.

    abstract：:Population genetic studies were carried out on 932 caucasians from Austria using the short tandem repeat system ACTBP2 (SEE33). A sequenced allelic ladder was used for typing (Möller et al. 1995). After native polyacrylamide gel electrophoresis all 26 alleles of the ladder were found as well as 194 alleles which migra...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050111

    authors： Klintschar M,Neuhuber F

    更新日期：1998-01-01 00:00:00

  • Ethical aspects of medical age assessment in the asylum process: a Swedish perspective.

    abstract：:According to European regulations and the legislations of individual member states, children who seek asylum have a different set of rights than adults in a similar position. To protect these rights and ensure rule of law, migration authorities are commonly required to assess the age of asylum seekers who lack reliabl...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-017-1730-3

    authors： Malmqvist E,Furberg E,Sandman L

    更新日期：2018-05-01 00:00:00

  • Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis?

    abstract：:In humans, the amelogenin gene is present on both the X and the Y chromosomes. However, there are size differences in this gene between these chromosomes, which have been utilised for sexing in forensic casework and prenatal diagnosis. Our study using the AmpFl STR Profiler Plus kit, showed a deletion of Y chromosome-...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-001-0262-y

    authors： Thangaraj K,Reddy AG,Singh L

    更新日期：2002-04-01 00:00:00

  • Allele frequencies for 15 STR loci in a population from the Republic of Macedonia.

    abstract：:Allele frequencies of 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA) were determined in a sample of 163 unrelated individuals from the Republic of Macedonia. AmpFISTR Identifiler Kit (Applied Biosystems) was used for PCR amplificatio...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-005-0025-2

    authors： Jakovski Z,Nikolova K,Furac I,Masic M,Janeska B,Kubat M

    更新日期：2006-01-01 00:00:00

  • Validation of six closely linked STRs located in the chromosome X centromere region.

    abstract：:We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb dista...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-009-0328-9

    authors： Edelmann J,Hering S,Augustin C,Kalis S,Szibor R

    更新日期：2010-01-01 00:00:00

  • Biostatistical evaluation of mixed stains with contributors of different ethnic origin.

    abstract：:The analysis of a mixed biological stain by means of highly polymorphic VNTR systems usually reveals a profile composed of multiple alleles. If the victim and one or several suspects match the profile the evidential strength of the matches has to be very carefully analysed. The appropriate methods for the statistical ...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050019

    authors： Fukshansky N,Bär W

    更新日期：1999-01-01 00:00:00

  • Morphology of sweat glands in determining time of death.

    abstract：:This study demonstrates post-mortem autolytic alterations in the skin at cellular and subcellular levels and identifies parameters which may assist in determining the time of death in the first few hours post-mortem. Serial skin samples from the ventral surface of the arm were taken at intervals of 3, 6, 9 and 12 h af...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/BF01225600

    authors： Cingolani M,Osculati A,Tombolini A,Tagliabracci A,Ghimenton C,Ferrara SD

    更新日期：1994-01-01 00:00:00

  • Decomposed liver has a significantly adverse affect on the development rate of the blowfly Calliphora vicina.

    abstract：:The development rate of immature Calliphora vicina reared on decomposed liver was significantly slower, by as much as 30 h (55.4 % of total development time) for mid-sized larvae, and 71 h (35.0 %) and 58 h (14.6 %) if using times to the onset of pupariation and eclosion, respectively, than those of immatures that dev...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s00414-012-0697-3

    authors： Richards CS,Rowlinson CC,Cuttiford L,Grimsley R,Hall MJ

    更新日期：2013-01-01 00:00:00

  • Stability of carbohydrate deficient transferrin (CDT) in stored blood samples.

    abstract：:The alcoholism marker CDT was determined on 257 blood samples 1-2 days after the blood samples were taken and again after storage for 7 months at +4 degrees C. The differences between the pairs of CDT values were so large that the determination of CDT after long term storage of the blood sample has no evidential value...

    journal_title：International journal of legal medicine

    pub_type： 杂志文章

    doi：10.1007/s004140050013

    authors： Köhler H,West A,Brinkmann B

    更新日期：2000-01-01 00:00:00