Abstract：
:Blood species identification is an important challenge in forensic science. Conventional methods used for blood species analysis are destructive and associated with time-consuming sample preparation steps. Nuclear magnetic resonance (NMR) spectroscopy is known for its nondestructive properties and fast results. This research study presents a proton (1H) NMR method to discriminate blood species including human, cat, dog, elephant, and bison. Characteristic signals acting as markers are observed for each species. Moreover, the data are evaluated by principle component analysis (PCA) and support vector machines (SVM). A 100% correct species recognition between human and nonhuman species is achieved using radial basis kernel function (RBF) and standardized data. The research study shows that 1H NMR spectroscopy is a powerful tool for differentiating human and nonhuman blood showing a great significance to forensic science.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Zailer E,Diehl BW,Monakhova YBdoi
10.1007/s00414-016-1500-7subject
Has Abstractpub_date
2017-05-01 00:00:00pages
723-729issue
3eissn
0937-9827issn
1437-1596pii
10.1007/s00414-016-1500-7journal_volume
131pub_type
杂志文章abstract：:A total of 17 Y-specific STR loci were studied in 12 districts of the European part of Russia aiming to ascertain the amount of substructure required for the construction of a representative regional database. All groups exhibited high haplotype diversities but low inter-population variance as measured by an analysis ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-007-0222-2
更新日期：2008-05-01 00:00:00
abstract：:This paper describes the general design and main results of the Italian proficiency testing program for the analysis of psychoactive substances in urine, a long-term initiative created in 1995 on an educational basis and characterized by an innovative internet-based service for data exchange between laboratories and t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050279
更新日期：1999-01-01 00:00:00
abstract：:Gabapentin (GBP) (Neurontin®, Horizant®, Gralise®) is a widely prescribed medication used primarily for the treatment of epilepsy and neuropathic pain. GBP has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and periphera...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1193-3
更新日期：2015-07-01 00:00:00
abstract：:Article 25 of the Charter of Fundamental Rights of the European Union (adopted in Nice on 7 December 2000) recognizes and respects the rights of older people to lead a life of dignity and independence and to participate in social and cultural life. It also highlights the importance of prevention and recognition of eld...
journal_title：International journal of legal medicine
pub_type： 杂志文章,实务指引
doi：10.1007/s00414-018-1880-y
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:The aim of this multi-reader feasibility study was to evaluate new post-processing CT imaging tools in rib fracture assessment of forensic cases by analyzing detection time and diagnostic accuracy. MATERIALS AND METHODS:Thirty autopsy cases (20 with and 10 without rib fractures in autopsy) were randomly select...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1412-6
更新日期：2017-03-01 00:00:00
abstract：:The hypothesis that antitussives containing ethylmorphine are abused by alcoholics and drug addicts and that this may lead to fatal poisonings where ethylmorphine causes or contributes to death was investigated. For this purpose 14 cases were analysed where a blood ethylmorphine concentration above the therapeutic lev...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050253
更新日期：1999-01-01 00:00:00
abstract：:Volatile substances are used widespread, especially among young people, as a cheap and easily accessible drug. Tetrachloroethylene is one of the solvents exerting effects on the central nervous system with experiences of disinhibition and euphoria. The case presented is that of a 27-year-old female, found dead by her ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1143-0
更新日期：2015-05-01 00:00:00
abstract：:The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectromet...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-001-0282-7
更新日期：2002-08-01 00:00:00
abstract：:The use of DNA to determine the ancestry of an individual is becoming more and more important in the areas of forensics. Kidd et al. (Forensic Sci Int Genet 12:215-224, 2014) have been the first to identify and catalog haplotypes, termed as minihaplotypes (1-10-kilobase spans) and microhaplotypes (≤ 200 bp), with pote...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1881-x
更新日期：2019-07-01 00:00:00
abstract：:When a forensic DNA sample cannot be associated directly with a previously genotyped reference sample by standard short tandem repeat profiling, the investigation required for identifying perpetrators, victims, or missing persons can be both costly and time consuming. Here, we describe the outcome of a collaborative s...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0788-1
更新日期：2013-05-01 00:00:00
abstract：:The alcoholism marker CDT was determined on 257 blood samples 1-2 days after the blood samples were taken and again after storage for 7 months at +4 degrees C. The differences between the pairs of CDT values were so large that the determination of CDT after long term storage of the blood sample has no evidential value...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050013
更新日期：2000-01-01 00:00:00
abstract：:A nucleotide polymorphism of C or T was detected at position 465 in the sex-determining region Y (SRY) gene. To evaluate the utility of this dimorphism in human population studies, the frequency and the frequency of the haplotype combined with the two polymorphic loci YAP and M9 were examined in a total of 130 unrelat...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004149900111
更新日期：2001-01-01 00:00:00
abstract：:The likelihood ratio is the fundamental quantity that summarizes the evidence in forensic cases. Therefore, it is important to understand the theoretical properties of this statistic. This paper is the last in a series of three, and the first to study linked markers. We show that for all non-inbred pairwise kinship co...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1416-2
更新日期：2016-11-01 00:00:00
abstract：:Scars of human skin can on occasions provide a very useful ancillary method of identification of an unknown deceased. If the age of any visible scars can be estimated objectively, then this might be of some assistance in the identification procedure. Melanocytes migrate into scar tissue as it ages and their number wit...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140100225
更新日期：2001-10-01 00:00:00
abstract：:A multiplex PCR was designed for the loci D2S1338, D16S539, D18S51, TH01 and FGA using redesigned primers in order to reduce the lengths of the amplification products compared to the designs used in commercially available multiplex PCR kits, also including amelogenin. The new PCR primers were used to amplify highly de...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0013-6
更新日期：2006-03-01 00:00:00
abstract：:Immunohistochemistry is a well-established technique used in many research laboratories as well as in clinical diagnostics. The method allows to visualize the expression of proteins in biological tissues, as well as to evaluate this expression semi-quantitatively. For diagnosis, an optimal staining, based on a straigh...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1575-9
更新日期：2017-11-01 00:00:00
abstract：:Current analysis of forensic DNA stains relies on the probabilistic interpretation of bulk-processed samples that represent mixed profiles consisting of an unknown number of potentially partial representations of each contributor. Single-cell methods, in contrast, offer a solution to the forensic DNA mixture problem b...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-021-02503-4
更新日期：2021-01-23 00:00:00
abstract：:One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be propose...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1781-0
更新日期：2018-09-01 00:00:00
abstract：:P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood-brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In thi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0849-0
更新日期：2013-05-01 00:00:00
abstract：:Warping has been used to determine the pre-burning condition of human skeletal remains. In the literature, this modification has been associated more often with the burning of fleshed and green bones, but it also arises during the burning of dry bones. The objective of this paper was to assess if bone collagen content...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1400-x
更新日期：2016-11-01 00:00:00
abstract：:We hypothesized that miRNAs present in vitreous humor could be a sort of "biological black box," storing information about physiological and environmental circumstances at death. As a proof of concept, we analyzed the vitreous humor miRNA signature to explore its forensic potential applications, such as determining th...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0811-6
更新日期：2013-05-01 00:00:00
abstract：:Isopropyl alcohol, or propan-2-ol (IPA), is found in numerous chemicals including alcohol-based hand rubs whose use has been recently widely extended to the general population since the onset of the COVID-19 pandemic. This widespread of IPA use could potentially, but not necessarily, be responsible for an increase in ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02444-4
更新日期：2021-01-01 00:00:00
abstract：:The scope of this study was to evaluate the incidence and the eventual consequences of amniotic fluid aspiration (AFA) in cases of sudden infant death. Cases of sudden infant death syndrome (SIDS; n = 113: 39 females, 74 males; mean age 4.6 months) were compared to a control group of 39 cases of explained death (14 fe...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0384-1
更新日期：2010-03-01 00:00:00
abstract：:The use of tracker dogs is the main method of finding hidden bodies, and in their search the dogs use typical scent patterns. "Electronic noses" can also be used to find and compare such patterns. Highly sensitive scent detectors have been successfully applied, e.g. in the examination of foodstuffs, in environmental t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0338-7
更新日期：2010-01-01 00:00:00
abstract：:A method has been developed for the simultaneous determination of lysergic acid diethylamide (LSD), its epimer iso-LSD, and its main metabolites nor-LSD and 2-oxo-3-hydroxy LSD in blood, urine, and, for the first time, vitreous humor samples. The method is based on liquid/liquid extraction and liquid chromatography-mu...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-006-0078-x
更新日期：2007-07-01 00:00:00
abstract：:In forensic science, the unequivocal identification of the cellular origin of crime scene samples used for DNA profiling can provide crucial information for crime scene reconstruction. We have previously shown that various mRNA markers from genes with expression patterns specific for blood and saliva can be establishe...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0249-z
更新日期：2009-01-01 00:00:00
abstract：:Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1232-0
更新日期：2015-09-01 00:00:00
abstract：:We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 %. The diversity values ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0705-7
更新日期：2012-07-01 00:00:00
abstract：:In many countries, assessment of legal age, also known as age of majority, has become increasingly important over the years. In China, individuals older than 18 years of age have full capacity regarding civil conduct and can be tried as an adult for criminal charges. Therefore, from a legal point of view, it is crucia...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1907-4
更新日期：2018-11-01 00:00:00
abstract：:A cross-sectional study was carried out to assess chronological age estimation based on the stages of third lower molar development, following the eight stages (A-H) method of Demirjian et al. The final sample consisted of 1,054 orthopantomograms from Spanish individuals of known chronological age (range 14-21 years) ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0530-3
更新日期：2005-11-01 00:00:00
