Abstract：
:A method has been developed for the simultaneous determination of lysergic acid diethylamide (LSD), its epimer iso-LSD, and its main metabolites nor-LSD and 2-oxo-3-hydroxy LSD in blood, urine, and, for the first time, vitreous humor samples. The method is based on liquid/liquid extraction and liquid chromatography-multiple mass spectrometry detection in an ion trap mass spectrometer, in positive ion electrospray ionization conditions. Five microliter of sample are injected and analysis time is 12 min. The method is specific, selective and sensitive, and achieves limits of quantification of 20 pg/ml for both LSD and nor-LSD in blood, urine, and vitreous humor. No significant interfering substance or ion suppression was identified for LSD, iso-LSD, and nor-LSD. The interassay reproducibilities for LSD at 20 pg/ml and 2 ng/ml in urine were 8.3 and 5.6%, respectively. Within-run precision using control samples at 20 pg/ml and 2 ng/ml was 6.9 and 3.9%. Mean recoveries of two concentrations spiked into drug free samples were in the range 60-107% in blood, 50-105% in urine, and 65-105% in vitreous humor. The method was successfully applied to the forensic determination of postmortem LSD levels in the biological fluids of a multi drug abuser; for the first time, LSD could be detected in vitreous humor.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Favretto D,Frison G,Maietti S,Ferrara SDdoi
10.1007/s00414-006-0078-xsubject
Has Abstractpub_date
2007-07-01 00:00:00pages
259-65issue
4eissn
0937-9827issn
1437-1596journal_volume
121pub_type
杂志文章abstract：:The ability to estimate stature from various parts of the body is essential in medicolegal investigations, particularly in cases in which human remains have been dismembered or mutilated. Therefore, the aim of this study was to generate linear regression models for predicting stature on the basis of sternum length in ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-0975-3
更新日期：2014-09-01 00:00:00
abstract：:The forensic application of mtDNA typing requires large databases which are regionally well defined. To further this aim, we have typed mtDNA in a sample of 111 French and 106 Sicilians. The French were typed for both hypervariable segments (HVR1 and HVR2) of the mtDNA control region, whereas the Sicilians were only t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140000169
更新日期：2001-01-01 00:00:00
abstract：:The use of phenethylamines in the dance scene is now well established. Apart from amphetamine, the commonest phenethylamine encountered in clinical and forensic settings is 3,4-methylenedioxymethamphetamine (MDMA) commonly known as ecstasy. Other phenethylamines, which have similar effects are encountered, such as 3,4...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050291
更新日期：2000-01-01 00:00:00
abstract：:Speckle interferometry is a non-destructive measurement technique using a laser. The principles of the method are described. Human hyoid bones (n = 10) were investigated. Loads were applied to individual points on the anterior surface of the body of hyoid bones. All hyoid bones showed an asymmetric displacement. The d...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01225233
更新日期：1993-01-01 00:00:00
abstract：:Hereditary hemochromatosis (HH) is a frequent autosomal recessive disease which causes iron-overload of various organs. Of all northern European affected individuals, 90-95% show 1 of 3 known point mutations in the HFE gene. Symptoms and organs involved can vary considerably: Only a small fraction of the 200,000-400,0...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0451-6
更新日期：2004-06-01 00:00:00
abstract：:The purpose of the present research is to study the radiographic visibility of the periodontal ligament in third molars from a northern Chinese population to determine if this methodology could be used for the 18-year threshold. A total of 1300 conventional orthopantomograms from 650 males and 650 females of northern ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1664-9
更新日期：2018-03-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake in the Results section. The correct equation from the cubic regression analysis for male is: Age = 14.408 + 0.475X-0.064X2 + 0.005X3, and for the female is: 18.196-1.637X + 0.204X2-0.005X3. The error doesn't affect the main conclusion. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00414-017-1751-y
更新日期：2018-01-01 00:00:00
abstract：:Biological samples, including skeletal remains exposed to environmental insults for extended periods of time, exhibit increasing levels of DNA damage and fragmentation. Human forensic identification methods typically use a combination of mitochondrial (mt) DNA sequencing and short tandem repeat (STR) analysis, which t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02110-4
更新日期：2019-09-01 00:00:00
abstract：:The original version of this article contained an author name error. In this article, Katrina Madella has been corrected to Katrina Maddela. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00414-019-02031-2
更新日期：2019-05-01 00:00:00
abstract：:Chumbinho is the popular name given to carbamate aldicarb (Temik), an insecticide commonly used in agriculture and highly toxic (LD50 = 0.9 mg/kg oral in rats) that has been sold clandestinely in several regions of Brazil. Chumbinho is sold illegally as raticide and is available in a formulation of small black granule...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1336-1
更新日期：2016-07-01 00:00:00
abstract：:A block of an injury instrument will be left in wounds sometimes, and the suspect instrument can be discriminated by comparison with the block that was left through elemental analysis. In this study, three brands (Shibazi, Zhangxiaoquan, Qiaoxifu) of kitchen knives with forged, chop, and slice application series were ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0829-4
更新日期：2014-03-01 00:00:00
abstract：:Allele frequencies of the Short tandem repeat systems HumVWA and HumACTBP2 were determined from 105 unrelated individuals from the area of Szeged, Hungary. A total of 8 alleles was detected for VWA, and 23 alleles were found for ACTBP2. In both systems no deviations from Hardy-Weinberg equilibrium were observed. A com...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF02432127
更新日期：1996-01-01 00:00:00
abstract：:Projectile impact in sandwich bones typically results in formation of conoidal wounds exhibiting a larger region of damage on the inner cortical plate termed the bevel. To date, a number of hypotheses have been put forward to explain the formation of this wound type. The plug and spall hypothesis suggests that the con...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02086-1
更新日期：2019-09-01 00:00:00
abstract：:The population origin of an individual is often requested to be determined from specimens left at a crime scene for identifying a suspect and individual identity. The melanocortin 1 receptor gene (MC1R) and P gene are associated with human pigmentation. Although several studies have reported that these genes are highl...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0289-4
更新日期：2009-05-01 00:00:00
abstract：:The genetic polymorphisms of 15 autosomal short tandem repeat (STR) loci included in the AmpFISTR Sinofiler™ kit were evaluated in 547 healthy unrelated Han individuals from Gansu, China. All of the loci reached the Hardy-Weinberg equilibrium after the Bonferroni correction (p > 0.0033). These loci were examined to de...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1132-8
更新日期：2015-07-01 00:00:00
abstract：:Short tandem repeats (STRs) are DNA regions with a variable number of repeated units (2-6 bp) and attractive to genetic application like forensic, population genetics, and anthropological studies. The Huaxia Platinum System allows the multiplex amplification of 23 autosomal STR loci and two gender determination loci. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1679-2
更新日期：2018-07-01 00:00:00
abstract：:Identification of unknown bodies is mainly made by dental examination and comparison with accurate dental records. Therefore it is necessary to examine the jaws carefully and to locate every tooth-coloured dental restoration. Overlooking dental fillings can make positive identification impossible. The technique descri...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050138
更新日期：1998-01-01 00:00:00
abstract：:To increase the reliability of forensic age estimations in living adolescents and young adults where there is no legitimation for X-ray examinations, it would be desirable to establish radiation-free imaging methods. In the present study, the ossification stage of the distal femoral epiphysis was determined retrospect...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-0967-3
更新日期：2014-05-01 00:00:00
abstract：:The polyvinyl alcohol method (PVAL) is known as an effective technique to thoroughly collect traces of gunshot residue (GSR) from different surfaces, e.g., from hands or gunshot wounds. Despite obvious advantages over other methods using adhesive tapes, PVAL is still not widely accepted and applied in routine case wor...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02166-2
更新日期：2020-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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更新日期：2010-11-01 00:00:00
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journal_title：International journal of legal medicine
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更新日期：2019-07-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2008-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050226
更新日期：1999-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0249-z
更新日期：2009-01-01 00:00:00
abstract：:CT scan coupled with autopsy is the gold standard for the forensic investigation of fatal road traffic accidents. The objective of the present paper is to demonstrate that from this, it is possible to reconstruct elements of an accident with minimal human and material resources using basic knowledge of three-dimension...
journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
abstract：:Acute aortic dissection (AAD) is a clinically "silent," but emergent and life-threatening cardiovascular disease, and hereditary factors play an important etiologic role in the development of AAD. The purposes of this study are to definitize the diagnostic yield of 59 AAD patients, investigate the molecular pathologic...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1890-9
更新日期：2018-09-01 00:00:00
abstract：:Performance of PowerPlex Fusion 6C kit (PP F6C) was assessed in 374 unrelated individuals belonging to Madhya Pradesh, an Indian state. The study evaluated the forensic parameters for the loci included in PP F6C Multiplex System. The combined discrimination power (CPD) and combined exclusion power (CPE) were 1 and 0.9...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02017-0
更新日期：2019-05-01 00:00:00
abstract：:A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. Mixed fields with anti-B and anti-A+B antisera led to the conclusion that blood group B and 0 cell populations were present in a 1:1 ratio...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0332-0
更新日期：2009-09-01 00:00:00
