Abstract:
:Performance of PowerPlex Fusion 6C kit (PP F6C) was assessed in 374 unrelated individuals belonging to Madhya Pradesh, an Indian state. The study evaluated the forensic parameters for the loci included in PP F6C Multiplex System. The combined discrimination power (CPD) and combined exclusion power (CPE) were 1 and 0.999999995, respectively, for all 23 autosomal STR loci. SE33 showed the greatest power of discrimination (0.990) in the studied population, whereas TPOX showed the lowest (0.843). The availability of three Y-STR loci in the Multiplex System is suitable for assessing male contribution and amelogenin deletion in a single Multiplex PCR simultaneously. The study also presents the first global report on polymorphism in the Indian population on SE 33 autosomal STR loci and PP Fusion 6C Multiplex System. The results revealed that the studied STR Multiplex System is highly polymorphic and suitable for forensic purposes.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Dixit S,Shrivastava P,Kumawat RK,Kaitholia K,Dash HR,Sharma H,Choubey Gdoi
10.1007/s00414-019-02017-0subject
Has Abstractpub_date
2019-05-01 00:00:00pages
803-805issue
3eissn
0937-9827issn
1437-1596pii
10.1007/s00414-019-02017-0journal_volume
133pub_type
杂志文章abstract::In kinship analysis, large data sets with estimated haplotype frequencies for marker clusters are very important for the likelihood calculation. Practical use of the X-STRs demonstrated that in some complex kinship cases, the marker set of the Investigator Argus X-12 kit can be insufficient. This study aimed to extend...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-020-02306-z
更新日期:2020-11-01 00:00:00
abstract::Biological samples, including skeletal remains exposed to environmental insults for extended periods of time, exhibit increasing levels of DNA damage and fragmentation. Human forensic identification methods typically use a combination of mitochondrial (mt) DNA sequencing and short tandem repeat (STR) analysis, which t...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02110-4
更新日期:2019-09-01 00:00:00
abstract::The hypothesis that antitussives containing ethylmorphine are abused by alcoholics and drug addicts and that this may lead to fatal poisonings where ethylmorphine causes or contributes to death was investigated. For this purpose 14 cases were analysed where a blood ethylmorphine concentration above the therapeutic lev...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050253
更新日期:1999-01-01 00:00:00
abstract::We investigated the polymorphism of five X-chromosomal short tandem repeat markers (ChrX STRs) loci (DXS7132, DXS981, DXS6803, DXS6809, and DXS6789) and their value for forensic applications. A fluorescent multiplex polymerase chain reaction (PCR) for amplifying five ChrX STRs loci in the same PCR reaction was set up....
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-008-0223-9
更新日期:2008-05-01 00:00:00
abstract::The smoking cessation agent varenicline acts as a partial agonist on α(4)β(2) nicotinic acetylcholine receptors. Although debated, several reports have linked varenicline therapy to an increased risk of suicidal thoughts and/or suicide. In addition, several non-fatal overdose cases have been reported. In this report, ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0695-5
更新日期:2013-01-01 00:00:00
abstract::Organophosphorus insecticides, such as parathion-ethyl, quinalphos, chlorpyrifos, chlorfenvinphos or diazinon, are still widely used for pest control on crops. These compounds are extremely toxic to humans, and, even though specific legislation exists that controls the use of these substances, the frequency of toxic a...
journal_title:International journal of legal medicine
pub_type: 杂志文章,评审
doi:10.1007/s00414-019-02119-9
更新日期:2019-11-01 00:00:00
abstract::A nucleotide polymorphism of C or T was detected at position 465 in the sex-determining region Y (SRY) gene. To evaluate the utility of this dimorphism in human population studies, the frequency and the frequency of the haplotype combined with the two polymorphic loci YAP and M9 were examined in a total of 130 unrelat...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004149900111
更新日期:2001-01-01 00:00:00
abstract::Establishing individuality is an imperative aspect in any investigation procedure. At times, it becomes necessary to determine the sex of the individual to establish identity, and saliva stains found at the scene of crime are of major help in such cases. In the present study, we have determined the sex of the individu...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-008-0285-8
更新日期:2009-09-01 00:00:00
abstract::Backspatter is the ejection of biological material from a gunshot entrance wound against the line of fire. This phenomenon was investigated experimentally in transverse gunshots to the heads of calves (n = 9) using two types of 9 mm Parabellum ammunition from shooting distances of 0-10 cm. The resulting bloodstains we...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01355519
更新日期:1996-01-01 00:00:00
abstract::Warping has been used to determine the pre-burning condition of human skeletal remains. In the literature, this modification has been associated more often with the burning of fleshed and green bones, but it also arises during the burning of dry bones. The objective of this paper was to assess if bone collagen content...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-016-1400-x
更新日期:2016-11-01 00:00:00
abstract::Hereditary hemochromatosis (HH) is a frequent autosomal recessive disease which causes iron-overload of various organs. Of all northern European affected individuals, 90-95% show 1 of 3 known point mutations in the HFE gene. Symptoms and organs involved can vary considerably: Only a small fraction of the 200,000-400,0...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-004-0451-6
更新日期:2004-06-01 00:00:00
abstract::A short tandem repeat at the D1S1656 locus was sequenced in 45 selected alleles and 13 different alleles were found which were designated according to the total number of repeats. This STR is a compound hypervariable STR consisting of blocks of (TAGR) repeats with a basic sequence structure (TAGA)4(TGA)0-1(TAGA)6-16(T...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050161
更新日期:1998-01-01 00:00:00
abstract::The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-009-0404-1
更新日期:2011-01-01 00:00:00
abstract::Alleles of the STR systems HumFES/FPS, HumVWA and HumD21S11 were sequenced and analyzed. Sequence data revealed 3 different systems concerning the complexity of their sequence structure. HumFES/FPS belongs to the STR polymorphism with a simple repeat structure. Only 2 subtypes were found with a base substitution in th...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01224779
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To elucidate postmortem computed tomography (PMCT) and postmortem magnetic resonance (PMMR) imaging findings suggesting massive fat embolism. MATERIALS AND METHODS:Consecutive forensic cases with PMCT and PMMR scans of subjects prior to autopsy were assessed. For PMCT, 16- or 64-row multidetector CT scans we...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02128-8
更新日期:2020-03-01 00:00:00
abstract::BamHI polymorphism at the VNTR locus D2S44 was investigated, concentrating on band frequencies, mutation rate and confirmation of Mendelian inheritance. In this series 39 restriction fragments showing frequencies less than 10% could clearly be distinguished. No mutations could be observed and the Mendelian character o...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01816481
更新日期:1990-12-01 00:00:00
abstract::Suppose that part of the prosecution's evidence in some crime case is analysis of a blood stain, and that the traits E discovered in the stain suggest multiple donors. Then the prosecution will probably allege some specific inculpatory hypothesis H0 about the sources of the stain, and P (E [symbol: see text] H0) can b...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01225523
更新日期:1996-01-01 00:00:00
abstract::Dendritic cells (DCs) can essentially contribute to innate and adaptive immune system in various organs. A double-color immunofluorescence analysis was carried out with anti-CD11c and -HLA-DRα antibodies to detect DCs in 53 skin wounds (their postinfliction intervals: group I, 0-3 days; group II, 4-7 days; group III, ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02185-z
更新日期:2020-03-01 00:00:00
abstract::Three immunohistochemically different myelomonocytic subtypes, i.e. MRP8, MRP14 and 27E10 were quantitatively evaluated in the intraalveolar, alveolar-interstitial and alveolar-intracapillary lung compartments. Lung sections from 5 major groups with defined causes of death, i.e. drowning and death during immersion (DI...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050091
更新日期:1997-01-01 00:00:00
abstract::Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1232-0
更新日期:2015-09-01 00:00:00
abstract::The genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci included in the GlobalFiler™ PCR Amplification Kit were evaluated in 3032 unrelated individuals Altay Han of Xinjiang, northwest China. All of the loci reached the Hardy-Weinberg equilibrium. These loci were examined to determine allele frequenci...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1641-3
更新日期:2018-01-01 00:00:00
abstract::Urine samples from 20 male volunteers of European Caucasian origin were stored at 4 degrees C over a 4-month period in order to compare the identification potential of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) markers. The amount of nDNA recovered from urines dramatically declined over time. Consequently, nDNA ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-005-0004-7
更新日期:2006-03-01 00:00:00
abstract::Projectile impact in sandwich bones typically results in formation of conoidal wounds exhibiting a larger region of damage on the inner cortical plate termed the bevel. To date, a number of hypotheses have been put forward to explain the formation of this wound type. The plug and spall hypothesis suggests that the con...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02086-1
更新日期:2019-09-01 00:00:00
abstract::Five short tandem repeat (STR) systems HumVWA, HumTH01, HumCD4, HumF13B and HumFES were investigated in 2 subpopulations living in Turkey (Laz Turks and Kurds). The population genetic data were compared to a Turkish population sample from the Adana area. A closer genetic relationship was found to the Laz Turks than to...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050059
更新日期:1997-01-01 00:00:00
abstract::In this study the development of a 13-locus multiplex-PCR system fitting the updated demands for paternity testing in Germany is described. For this purpose an existing multiplex PCR system that allows the simultaneous amplification of eight different STR loci together with the sex-specific locus amelogenin ( genRESMP...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-003-0420-5
更新日期:2004-02-01 00:00:00
abstract::The yaw angle in flight of high velocity bullets has been discussed for a number of years, due to its contribution to the tumbling of the bullet in the target. Since few unclassified reports of contemporary bullets are available, we investigated the yaw angles of the bullets used in the M16A2, G3, AK-47 and AK-74 rifl...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01225601
更新日期:1994-01-01 00:00:00
abstract::CT scan coupled with autopsy is the gold standard for the forensic investigation of fatal road traffic accidents. The objective of the present paper is to demonstrate that from this, it is possible to reconstruct elements of an accident with minimal human and material resources using basic knowledge of three-dimension...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0789-0
更新日期:2013-09-01 00:00:00
abstract::The craniofacial superimposition technique is still an important way of identifying skulls when there is no reference sample for a forensic DNA analysis, when DNA typing from remaining tissue samples has failed, or when antemortem dental records are not available. Through the widespread use of digital photography, the...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-010-0494-9
更新日期:2010-09-01 00:00:00
abstract::A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. Mixed fields with anti-B and anti-A+B antisera led to the conclusion that blood group B and 0 cell populations were present in a 1:1 ratio...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-009-0332-0
更新日期:2009-09-01 00:00:00
abstract::A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin K deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01369825
更新日期:1996-01-01 00:00:00