Population genetic analysis of the Globalfiler STR loci in 3032 individuals from the Altay Han population of Xinjiang in northwest China.

Abstract:

:The genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci included in the GlobalFiler™ PCR Amplification Kit were evaluated in 3032 unrelated individuals Altay Han of Xinjiang, northwest China. All of the loci reached the Hardy-Weinberg equilibrium. These loci were examined to determine allele frequencies and forensic statistical parameters. SE33 showed the greatest power of discrimination in Altay Han population, whereas TPOX showed the lowest. The combined discrimination power and probability of excluding paternity of the 21 autosomal STR loci were 0.999999999999999999999999889838 and 0.999999996664704, respectively. Both pairwise genetic distance and phylogenetic methods indicated that the Altay Han had the closest genetic relationship with the Han origin and Hui populations. The present results revealed that the GlobalFiler system had a high level of polymorphism in Altay Han population and hence could be a powerful tool for forensic application and population genetic study.

journal_name

Int J Legal Med

authors

Li X,Li L,Wang Q,Zhang J,Ge W,Bai R,Yu X,Shi M

doi

10.1007/s00414-017-1641-3

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

141-143

issue

1

eissn

0937-9827

issn

1437-1596

pii

10.1007/s00414-017-1641-3

journal_volume

132

pub_type

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