Abstract:
:The genetic polymorphisms of 21 autosomal short tandem repeat (STR) loci included in the GlobalFiler™ PCR Amplification Kit were evaluated in 3032 unrelated individuals Altay Han of Xinjiang, northwest China. All of the loci reached the Hardy-Weinberg equilibrium. These loci were examined to determine allele frequencies and forensic statistical parameters. SE33 showed the greatest power of discrimination in Altay Han population, whereas TPOX showed the lowest. The combined discrimination power and probability of excluding paternity of the 21 autosomal STR loci were 0.999999999999999999999999889838 and 0.999999996664704, respectively. Both pairwise genetic distance and phylogenetic methods indicated that the Altay Han had the closest genetic relationship with the Han origin and Hui populations. The present results revealed that the GlobalFiler system had a high level of polymorphism in Altay Han population and hence could be a powerful tool for forensic application and population genetic study.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Li X,Li L,Wang Q,Zhang J,Ge W,Bai R,Yu X,Shi Mdoi
10.1007/s00414-017-1641-3subject
Has Abstractpub_date
2018-01-01 00:00:00pages
141-143issue
1eissn
0937-9827issn
1437-1596pii
10.1007/s00414-017-1641-3journal_volume
132pub_type
杂志文章abstract::A population database was generated from 118 unrelated Caucasoid individuals living in Spain. Sequence polymorphisms of the mitochondrial DNA (mtDNA) control region, hypervariable regions I and II (HVRI and HVRII) were determined using the polymerase chain reaction (PCR) and direct sequencing. A total of 102 different...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140000158
更新日期:2000-01-01 00:00:00
abstract::Due to the requirement to minimise exposure to radiation, it is desirable to develop non-ionising imaging procedures for the analysis of skeletal maturation for forensic age diagnostics in living individuals. The present pilot study analyses the applicability of ultrasound examinations for the evaluation of apophyseal...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-011-0554-9
更新日期:2011-03-01 00:00:00
abstract::One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be propose...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-018-1781-0
更新日期:2018-09-01 00:00:00
abstract::During forensic investigations, it is often important to be able to distinguish between impact spatter patterns (blood from gunshots, explosives, blunt force trauma and/or machinery accidents) and bloodstain patterns generated by expiration (blood from the mouth, nose or lungs). These patterns can be difficult to dist...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-010-0498-5
更新日期:2011-11-01 00:00:00
abstract::(-)-Δ-9-tetrahydrocannabinol ((-)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (-)-11-hydroxy-Δ-9-tetrahydrocannabinol ((-)-11-OH-Δ-9-THC), which is psychoactive, and to (-)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol ((-)-Δ-9-THC-COOH), which is psychoinacti...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-020-02387-w
更新日期:2020-11-01 00:00:00
abstract::The identification of species of the forensically important genus Sarcophaga is very difficult and requires strong taxonomic expertise. In this study, we sequenced the mitochondrial cytochrome c oxidase subunit I (COI) gene of 126 specimens of 56 W European Sarcophaga species and added GenBank data to our database to ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0767-6
更新日期:2013-03-01 00:00:00
abstract::The main criteria used in dental age estimation in living young individuals are mineralisation and eruption of the third molars. In order to further diversify the spectrum of characteristics after completion of third molar development, tests were undertaken to determine whether the characteristics studied by Gustafson...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0701-y
更新日期:2012-07-01 00:00:00
abstract::We present a duo paternity test case to assess the biological relationship between a woman and her female child. After analyzing 57 autosomal and 19 X-chromosomal short tandem repeat loci, mother-daughter exclusions were discovered at four loci, which were all located on chromosome 2. Further testing of whole-genome s...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-018-1857-x
更新日期:2019-07-01 00:00:00
abstract::Blunt force is a frequently used type of violence especially because it can be performed with basically every object of our daily lives or with bare hands or feet. The injuries and medical consequences have been widely examined, whereas the forces and especially the energies acting on impact have rarely been analyzed....
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1689-0
更新日期:2018-01-01 00:00:00
abstract::Anthropologists are constantly seeking to improve methods for age estimation in the human skeleton. A new method was introduced about a decade ago that assesses the morphological changes that take place in the acetabulum as an individual ages. The pelvis is usually well preserved in forensic cases, which makes this me...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1299-7
更新日期:2016-05-01 00:00:00
abstract::Projectile impact in sandwich bones typically results in formation of conoidal wounds exhibiting a larger region of damage on the inner cortical plate termed the bevel. To date, a number of hypotheses have been put forward to explain the formation of this wound type. The plug and spall hypothesis suggests that the con...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02086-1
更新日期:2019-09-01 00:00:00
abstract::Postmortem ethanol formation is a well-known problem in forensic toxicology. The aim of this study was to interpret findings of ethanol in blood, in a large collection of forensic autopsy cases, by use of the nonoxidative ethanol metabolites, ethyl glucuronide (EtG), and ethyl sulfate (EtS). In this study, according t...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-014-1031-z
更新日期:2014-09-01 00:00:00
abstract::Blunt thoracic aortic injury (BTAI) resulting from cardiopulmonary resuscitation (CPR) is rarely reported and most reports are of aortic rupture. Clinical reports have also documented aortic dissection and intramural hematomas with sequential imaging showing the development of these aortic injuries after the administr...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-016-1377-5
更新日期:2016-11-01 00:00:00
abstract::Short tandem repeats (STRs) are DNA regions with a variable number of repeated units (2-6 bp) and attractive to genetic application like forensic, population genetics, and anthropological studies. The Huaxia Platinum System allows the multiplex amplification of 23 autosomal STR loci and two gender determination loci. ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1679-2
更新日期:2018-07-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) from 100 unrelated British White Caucasians was extracted, amplified and directly sequenced. Sequences of approximately 800 nucleotides were obtained from 2 hypervariable segments within the non-coding region of the mitochondrial genome. A total of 91 different sequences were observed with an...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01225046
更新日期:1993-01-01 00:00:00
abstract::P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood-brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In thi...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-013-0849-0
更新日期:2013-05-01 00:00:00
abstract::A total of 34 deployed driver and passenger airbags from altogether 20 vehicles after frontal collisions were investigated. In 80% of the airbags possible biological traces could be located with an alternative light source (ALS, Polilight) at a wavelength of 450-470 nm. These traces were swabbed, a part of them additi...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-003-0406-3
更新日期:2004-02-01 00:00:00
abstract::Shooting incidents are often portrayed as resulting in a sometimes violent backwards displacement of the victim. This opinion is also not infrequently held by expert witnesses. The physical force responsible for this would be momentum (mass x velocity). The physics of momentum in ballistic injury is explained in detai...
journal_title:International journal of legal medicine
pub_type: 杂志文章,评审
doi:10.1007/BF01369676
更新日期:1996-01-01 00:00:00
abstract::A population study in a sample of 211 unrelated individuals from 2 cities in North and Central Italy was carried out to investigate the short tandem repeat (STR) system HUMVWA31. Separation of PCR- amplified DNA fragments was performed by high-resolution horizontal denaturing polyacrylamide gel electrophoresis (PAGE) ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01428399
更新日期:1995-01-01 00:00:00
abstract::In order to establish a reliable age indicator in the period when all other epiphyseal age indicators have already been inactivated, medial clavicle as the bone with the longest period of growth became the object of various investigations. However, the lack of population-specific method often made it unreliable in som...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0791-6
更新日期:2013-05-01 00:00:00
abstract::On September 23rd 1993 Genova was flooded by heavy rainstorms and 4 people disappeared, including an elderly couple. Four days later a partially skeletonized body was found floating near the coast. No visual identification was possible. Autopsy findings were consistent with the medical history of a possible victim. DN...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01428409
更新日期:1995-01-01 00:00:00
abstract::One of the most common conditions during fetal development is anencephaly, which often involves many identification difficulties in the context of physical anthropology, as it causes severe skull challenges. In this paper, we describe the alterations found in the skulls of two perinatal individuals with anencephaly fr...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-014-1123-9
更新日期:2015-07-01 00:00:00
abstract::The utility of postmortem microbiology has continuously been a topic of controversy. The present study describes a case of fatal sepsis in a patient with systemic lupus erythematosus. Postmortem culture and genotyping analyses allowed us to identify Klebsiella pneumoniae as the cause of sepsis, revealing the inadequat...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1160-z
更新日期:2015-09-01 00:00:00
abstract::A 28-year-old man was shot in the back of the head at close range by a robber who then locked him in a room assuming that he was dead. The man was discovered 2 days later. The entrance wound of the bullet was in the left occipital region and it passed into the periphery of the right temporal lobe, where it lodged. The...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004149900120
更新日期:2000-01-01 00:00:00
abstract::Dendritic cells (DCs) can essentially contribute to innate and adaptive immune system in various organs. A double-color immunofluorescence analysis was carried out with anti-CD11c and -HLA-DRα antibodies to detect DCs in 53 skin wounds (their postinfliction intervals: group I, 0-3 days; group II, 4-7 days; group III, ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02185-z
更新日期:2020-03-01 00:00:00
abstract::Mixture DNA profiles commonly appear in forensic genetics, and a large number of statistical methods and software are available for such cases. However, most of the literature concerns mixtures where the contributors are assumed unrelated and the genetic markers are unlinked. In this paper, we consider mixtures of lin...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1288-x
更新日期:2016-05-01 00:00:00
abstract::The semi-quantitative analysis of decomposed bone of rats exposed to colchicine and euthanized following different time intervals postexposure (i.e., dose-death interval, DDI) is described. Rats received colchicine (50 mg/kg, i.p.) and were euthanized 30 min (DDI1; n = 4), 60 min (DDI2; n = 4), or 180 min (DDI3; n = 4...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1196-0
更新日期:2016-03-01 00:00:00
abstract::STR-based individualisation of biological deposits on bullets after perforation of tissue, can identify the person injured or killed by a particular bullet and comparison with the firearms used can identify the weapon and thus possibly the person who did the shooting. In this study, the effect of subsequent impacts on...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140000203
更新日期:2001-01-01 00:00:00
abstract::The localization of ABH related antigens in human male reproductive tract was examined using monoclonal antibodies and an avidin biotin complex method. No positive reaction with blood group antibodies on spermatozoa was observed in testis and ductus epididymidis apart from erythrocytes and endothelial cells. The expre...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF02340827
更新日期:1992-01-01 00:00:00
abstract::A multiplex PCR was designed for the loci D2S1338, D16S539, D18S51, TH01 and FGA using redesigned primers in order to reduce the lengths of the amplification products compared to the designs used in commercially available multiplex PCR kits, also including amelogenin. The new PCR primers were used to amplify highly de...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-005-0013-6
更新日期:2006-03-01 00:00:00