Abstract：
:A population database was generated from 118 unrelated Caucasoid individuals living in Spain. Sequence polymorphisms of the mitochondrial DNA (mtDNA) control region, hypervariable regions I and II (HVRI and HVRII) were determined using the polymerase chain reaction (PCR) and direct sequencing. A total of 102 different sequences were found as defined by 105 variable positions. The most common sequence occurred six times, and this sequence is also the most frequent in other European populations such as Austria, Germany and Britain. The mean pair-wise difference for the two HVR regions taken together was 7.74. The study revealed that transitions made up the majority of the variations (88%), whereas we observed a significantly lower frequency of transversions (8%). Also one individual in this study was observed with two positions of heteroplasmy at nucleotides 150 (C/T) and 153 (G/A). A statistical estimate of the results for this population showed a genetic diversity of 0.99. The probability of two random individuals showing identical mtDNA haplotypes is 1.3%. In order to use the mtDNA analysis in forensic casework, we consider that it is of crucial importance to know the frequency of the different sequences of mtDNA, and this data base study could be a useful tool to statistically evaluate the results.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Crespillo M,Luque JA,Paredes M,Fernández R,Ramírez E,Valverde JLdoi
10.1007/s004140000158subject
Has Abstractpub_date
2000-01-01 00:00:00pages
130-2issue
1-2eissn
0937-9827issn
1437-1596journal_volume
114pub_type
杂志文章abstract：:The assessment of age at death for identification purposes is a frequent and tough challenge for forensic pathologists and anthropologists. Too frequently, visual assessment of age is performed on well-preserved corpses, a method considered subjective and full of pitfalls, but whose level of inadequacy no one has yet ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1042-9
更新日期：2015-07-01 00:00:00
abstract：:In the past, numerous studies have documented the possibility of intraindividual differing appearances of the paired age-marker "medial clavicular ossification" in borderline adults. However, the extent of the divergences is rarely mentioned. Against that the article describes this phenomenon from a large sample of 25...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1694-3
更新日期：2018-03-01 00:00:00
abstract：:Myocardial infarctions go along with biomechanical stress, i.e. stretching of muscle fibres, and the expression of certain marker molecules. We tested if two of those markers, endothelin-1 (ET-1) and growth differentiation factor 15 (GDF-15), can be used as immunohistochemical markers for myocardial ischaemia/infarcti...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1726-z
更新日期：2018-03-01 00:00:00
abstract：:Allele frequencies and forensic parameters for 17 autosomal short tandem repeat (STR) loci were investigated from 1542 individuals of Va ethnic minority in Yunnan Province in the southwest of China. Also, genetic distances between Va and 13 published populations were compared, and a neighbor-joining (NJ) phylogenetic ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1620-8
更新日期：2017-09-01 00:00:00
abstract：:Three immunohistochemically different myelomonocytic subtypes, i.e. MRP8, MRP14 and 27E10 were quantitatively evaluated in the intraalveolar, alveolar-interstitial and alveolar-intracapillary lung compartments. Lung sections from 5 major groups with defined causes of death, i.e. drowning and death during immersion (DI...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050091
更新日期：1997-01-01 00:00:00
abstract：:The purpose of this study was to explore the applicability of periodontal ligament visibility (PLV) at the 18-year threshold. This mandibular maturity marker is graded into four separate age related stages, PLV-A, PLV-B, PLV-C, and PLV-D. These are discernible on a dental panoramic tomograph (DPT). The sample comprise...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1468-3
更新日期：2017-05-01 00:00:00
abstract：:A nucleotide polymorphism of C or T was detected at position 465 in the sex-determining region Y (SRY) gene. To evaluate the utility of this dimorphism in human population studies, the frequency and the frequency of the haplotype combined with the two polymorphic loci YAP and M9 were examined in a total of 130 unrelat...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004149900111
更新日期：2001-01-01 00:00:00
abstract：:Six synthetic head models wearing ballistic protective helmets were used to recreate two military combat-related shooting incidents (three per incident, designated 'Incident 1' and 'Incident 2'). Data on the events including engagement distances, weapon and ammunition types was collated by the Defence Science and Tech...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1802-z
更新日期：2019-01-01 00:00:00
abstract：:Abstract DNA typing of four tetrameric repeat loci (HUMVWA, HUMTH0I, D21SII and HPRT) was carried out in a Chinese Han population from Shanghai (East China) and one from Guangzhou (South-East China) using a quadruplex PCR amplification and detection of the fluorescent-labeled alleles on the ALF DNA sequencer. All loci...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050187
更新日期：1998-01-01 00:00:00
abstract：:Lactate dehydrogenase isoenzyme patterns indicative of vaginal injury were identified in extracts of a bloodstain on a pair of knickers belonging to a 4-year-old girl. No evidence of semen or saliva was detected in the stain. The result corroborated the clinical findings and provided strong evidence of child sexual ab...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01625173
更新日期：1992-01-01 00:00:00
abstract：:Population studies on six short tandem repeat loci, HUMF13A01, HUMFXIIIB, HUMLIPOL, HUMTH01, HUMTPOX and HUMVWFA31 were carried out in a sample of unrelated Japanese individuals (n = 337-545) living in Gifu Prefecture (central region of Japan). Five alleles could be identified for HUMFXIIIB, six for HUMF13A01, HUMLIPO...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369599
更新日期：1996-01-01 00:00:00
abstract：:This study demonstrates post-mortem autolytic alterations in the skin at cellular and subcellular levels and identifies parameters which may assist in determining the time of death in the first few hours post-mortem. Serial skin samples from the ventral surface of the arm were taken at intervals of 3, 6, 9 and 12 h af...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01225600
更新日期：1994-01-01 00:00:00
abstract：:In certain circumstances, tumour tissue specimens are the only DNA resource available for forensic DNA analysis. However, cancer tissues can show microsatellite instability and loss of heterozygosity which, if concerning the short tandem repeats (STRs) used in the forensic field, can cause misinterpretation of the res...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0443-7
更新日期：2011-05-01 00:00:00
abstract：:Projectile impact in sandwich bones typically results in formation of conoidal wounds exhibiting a larger region of damage on the inner cortical plate termed the bevel. To date, a number of hypotheses have been put forward to explain the formation of this wound type. The plug and spall hypothesis suggests that the con...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02086-1
更新日期：2019-09-01 00:00:00
abstract：:The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectromet...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-001-0282-7
更新日期：2002-08-01 00:00:00
abstract：:The level of exposure or concealment of a cadaver is known to have an important impact on insect colonisation and decomposition but has been the subject of few investigations. In the present study, 30 pig carcasses were stored in three different types of containers (suitcases, trashcans and drums) with different level...
journal_title：International journal of legal medicine
pub_type：
doi：10.1007/s00414-019-02089-y
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The annual number of detainees held in police custody in France is approximately 700,000. Medical data regarding arrestees are scarce across countries. We present the medical characteristics of detainees kept in police custody, including addictive behaviours and high-risk medical situations. M...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-0990-4
更新日期：2014-09-01 00:00:00
abstract：:Genetic diversity indices and forensic parameters at 20 autosomal short tandem repeat (STR) loci were evaluated in 233 unrelated individuals of Himachal Pradesh, India. In total, 255 alleles were observed with an average of 11.25 ± 0.88 alleles per locus. None of the loci deviated from Hardy Weinberg Equilibrium. The ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02254-8
更新日期：2020-09-01 00:00:00
abstract：:This paper describes the general design and main results of the Italian proficiency testing program for the analysis of psychoactive substances in urine, a long-term initiative created in 1995 on an educational basis and characterized by an innovative internet-based service for data exchange between laboratories and t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050279
更新日期：1999-01-01 00:00:00
abstract：:Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1232-0
更新日期：2015-09-01 00:00:00
abstract：:To better characterize the morphologic changes in electrocution, morphologic changes in the hearts of 21 subjects, who died instantaneously of electrocution, were compared to the hearts of decedents with different types of death. Sixteen myocardial samples per heart were processed for histological examination, and sec...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0011-8
更新日期：2006-03-01 00:00:00
abstract：:Allele frequencies and forensic statistics of 13 autosomal short tandem repeat loci were estimated in 56 unrelated Iranian individuals. Except for two loci which were monomorph, a total of 5-11 alleles at each locus were observed and altogether 94 alleles for all selected loci were found. Our results show that 11 out ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1342-3
更新日期：2016-11-01 00:00:00
abstract：:Falls over railings are frequent case scenarios forensic experts are confronted with. An important issue is the differentiation of accidental and non-accidental falling scenarios. From a biomechanical point of view, this is a challenging task and should be addressed in a multifactorial approach. This work presents a s...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02432-8
更新日期：2021-01-01 00:00:00
abstract：:The use of phenethylamines in the dance scene is now well established. Apart from amphetamine, the commonest phenethylamine encountered in clinical and forensic settings is 3,4-methylenedioxymethamphetamine (MDMA) commonly known as ecstasy. Other phenethylamines, which have similar effects are encountered, such as 3,4...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050291
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:The response to traumatic brain injury (TBI) is complex and induces various biological pathways in all brain regions that contribute to bad outcomes. The cerebellar hypoxia after a frontal cortex injury may potentiate the pathophysiological impacts of TBI. Therefore, a gene expression analysis was conducted to ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1129-3
更新日期：2015-07-01 00:00:00
abstract：:Linking biological samples found at a crime scene with the actual crime event represents the most important aspect of forensic investigation, together with the identification of the sample donor. While DNA profiling is well established for donor identification, no reliable methods exist for timing forensic samples. He...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0457-1
更新日期：2010-09-01 00:00:00
abstract：INTRODUCTION:The determination of age of majority (the 18-year-old threshold) using the popular Demirjian tooth staging method is unreliable, so other maturity markers are required. This study examines whether the Root Pulp Visibility (RPV) of the mandibular third molar is a useful indicator of age. METHODS:One thousa...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02155-5
更新日期：2020-01-01 00:00:00
abstract：:Evaluation of the radiographic visibility of root pulp in mandibular third molars has been suggested as an alternative method for estimation of legal age threshold in living individuals when the root apices are mature. Here, we assessed the accuracy of this method for age thresholds of 18 and 21 years. A sample of 463...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02036-x
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:As sex estimation is an important step to delineate the biological profile, the development of tools employing anatomical structures which may maintain their integrity even after extreme events, such as the maxillary sinus, become useful for forensic identification. Thus, the aim in the present study was to ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1869-6
更新日期：2019-07-01 00:00:00
abstract：:During forensic investigations, it is often important to be able to distinguish between impact spatter patterns (blood from gunshots, explosives, blunt force trauma and/or machinery accidents) and bloodstain patterns generated by expiration (blood from the mouth, nose or lungs). These patterns can be difficult to dist...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0498-5
更新日期：2011-11-01 00:00:00
