Different types of structural variation in STRs: HumFES/FPS, HumVWA and HumD21S11.


:Alleles of the STR systems HumFES/FPS, HumVWA and HumD21S11 were sequenced and analyzed. Sequence data revealed 3 different systems concerning the complexity of their sequence structure. HumFES/FPS belongs to the STR polymorphism with a simple repeat structure. Only 2 subtypes were found with a base substitution in the 5'-flanking region and no variation in the repeat region. In the STR system HumVWA the sequence structure of the repeat region is more complex, because 2 tetranucleotide units TCTA and TCTG were present. Additionally allele 14 revealed a completely different sequence structure leading to a different electrophoretic mobility. The repeat region of HumD21S11 is compound in structure. The possibility of variation at 3 positions leads to the occurrence of microheterogeneities in fragments of apparent length. In the upper allele range alleles arise with an additional incomplete TA-repeat.


Int J Legal Med


Möller A,Meyer E,Brinkmann B




Has Abstract


1994-01-01 00:00:00












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    journal_title:International journal of legal medicine

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    authors: Maeda H,Uramatsu M,Nakajima S,Yoshida KI

    更新日期:2016-11-01 00:00:00

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    journal_title:International journal of legal medicine

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    authors: Bévalot F,Gustin MP,Cartiser N,Gaillard Y,Le Meur C,Fanton L,Guitton J,Malicier D

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    journal_title:International journal of legal medicine

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    journal_title:International journal of legal medicine

    pub_type: 杂志文章


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    journal_title:International journal of legal medicine

    pub_type: 杂志文章


    authors: Benali L,Gromb S,Bou C

    更新日期:2013-09-01 00:00:00