Abstract：
:The smoking cessation agent varenicline acts as a partial agonist on α(4)β(2) nicotinic acetylcholine receptors. Although debated, several reports have linked varenicline therapy to an increased risk of suicidal thoughts and/or suicide. In addition, several non-fatal overdose cases have been reported. In this report, we utilised a sample preparation procedure suitable for postmortem samples and gas chromatography coupled to mass spectrometry to analyse samples obtained from a suicidal case in which ingestion of an overdose of varenicline had occurred. Extremely high concentrations of varenicline (>250 ng/ml) were detected in the blood of the deceased, in addition to high concentrations in urine and vitreous humour. To the best of our knowledge, similar high concentrations have not been reported yet. Although, with respect to the mechanism of death in this case, confounding factors were concomitant ethanol consumption and, importantly, potentially fatal hypothermia, this is the first report of a fatality associated with the ingestion of an overdose of varenicline.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Stove CP,De Letter EA,Piette MH,Lambert WEdoi
10.1007/s00414-012-0695-5subject
Has Abstractpub_date
2013-01-01 00:00:00pages
85-91issue
1eissn
0937-9827issn
1437-1596journal_volume
127pub_type
杂志文章abstract：:The diagnosis of drowning is one of the most difficult in forensic medicine. Forensic diatomology has been proposed to be useful in solving the diagnosis of drowning and considered to be a reliable indicator of the site of drowning. The Yangtze River and Jialing River are the main rivers in the Chongqing area (China),...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02297-x
更新日期：2020-07-01 00:00:00
abstract：:When blood reaches an extracorporeal surface, a drying process is initiated. Properties of this drying process may be crucial for the correct assessment of case-specific time lapses, however, there is a lack of systematic studies concerning the drying times of blood. We present a study on drying properties of small bl...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0734-2
更新日期：2012-09-01 00:00:00
abstract：:This paper describes the general design and main results of the Italian proficiency testing program for the analysis of psychoactive substances in urine, a long-term initiative created in 1995 on an educational basis and characterized by an innovative internet-based service for data exchange between laboratories and t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050279
更新日期：1999-01-01 00:00:00
abstract：:Cyanide (CN) blood concentration is hardly considered during routine when evaluating smoke gas intoxications and fire victims, although some inflammable materials release a considerable amount of hydrogen cyanide. CN can be significant for the capacity to act and can in the end even be the cause of death. Systematic d...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1426-0
更新日期：2017-01-01 00:00:00
abstract：:The Ion AmpliSeq™ HID single nucleotide polymorphism (SNP) panel, a primer pool of 103 autosomal SNPs and 33 Y-SNPs, was evaluated using the Ion 314™ Chip on the Ion PGM™ Sequencer with four DNA samples. The study focused on the sequencing of DNA at three different initial target quantities, related interpretation iss...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0879-7
更新日期：2013-11-01 00:00:00
abstract：:We measured the quantity of D-aspartic acid (degree of racemization of aspartic acid) in the enamel of different types of teeth from the same individual. We studied the correlation between the degree of racemization and the time of formation of each particular tooth, as well as the applicability of the degree of racem...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0506-8
更新日期：2005-03-01 00:00:00
abstract：:In forensic science, anthropology, and archaeology, several techniques have been developed to estimate chronological age in both children and adults, using the relationship between age and morphological changes in the structure of teeth. Before implementing a statistical model to describe age as a function of the meas...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0349-4
更新日期：2009-07-01 00:00:00
abstract：:The case of a man's death as a consequence of an accident with a mountain bike was examined. Despite only slight external injuries, a general examination revealed the existence of a rupture of the diaphragm which was the ultimate cause of death. The discussion reconstructs the way the accident occurred and briefly ana...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140100237
更新日期：2001-12-01 00:00:00
abstract：:The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectromet...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-001-0282-7
更新日期：2002-08-01 00:00:00
abstract：:The goal of the present study is to examine cross-sectional information on the growth of the humerus based on the analysis of four measurements, namely, diaphyseal length, transversal diameter of the proximal (metaphyseal) end of the shaft, epicondylar breadth and vertical diameter of the head. This analysis was perfo...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0713-7
更新日期：2013-01-01 00:00:00
abstract：:In a Japanese population study of the D1S80 locus 24 alleles ranging from allele 16 to allele43 were analysed using PCR-RFLP. As two repeat units were found to contain the restriction cleavage site (CCAGG) for EcoRII, we digested the alleles with EcoRII, separated the digested fragments on polyacrylamide gels and stai...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050146
更新日期：1998-01-01 00:00:00
abstract：:A block of an injury instrument will be left in wounds sometimes, and the suspect instrument can be discriminated by comparison with the block that was left through elemental analysis. In this study, three brands (Shibazi, Zhangxiaoquan, Qiaoxifu) of kitchen knives with forged, chop, and slice application series were ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0829-4
更新日期：2014-03-01 00:00:00
abstract：:A medicolegal/algological collaboration lasting several years aimed at developing methods for dealing with dead bodies found in water where the circumstances are not clear, has led to an interdisciplinary procedure. To enable algological analysis, sample preservation and preparation must be free from contamination or ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s004149900122
更新日期：2000-01-01 00:00:00
abstract：:In many forensic cases, the existence of a traumatic brain injury (TBI) is an essential factor, and the determination of the survival time is nearly as important as the determination of whether or not a trauma exists. Since it is known that glucose uptake increases in injured brain cells in order to perpetuate the neu...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1893-6
更新日期：2019-07-01 00:00:00
abstract：:The aim of this paper is twofold: first, to evaluate an Indian sample by Cameriere's European formula; and second, if this formula turns out to be unsuitable, to study a specific formula for Indian children. Orthopantomographs taken from 480 Indian children (227 girls and 253 boys) aged between 3 and 15 years were ana...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0427-7
更新日期：2010-05-01 00:00:00
abstract：:P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood-brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby influencing the treatment response and toxicity of P-gp substrates like citalopram and venlafaxine. In thi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0849-0
更新日期：2013-05-01 00:00:00
abstract：:In clinical and forensic practice, fatal thromboembolism is a major problem, particularly in a patient with no pre-existing risk factors. Out of a recent case, we discuss here the criteria for age determination of venous thrombi in a 46-year-old female with concomitant deep vein thrombosis in the common femoral left v...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1705-4
更新日期：2018-05-01 00:00:00
abstract：:Various aspects concerning the practical application and forensic interpretation of data obtained by saliva drug testing and drug monitoring from the skin surface are discussed. Basic information on the composition of saliva and skin secretions and their particular transport mechanisms, as far as known, are given. For...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s004140050239
更新日期：1999-01-01 00:00:00
abstract：:To investigate the genetic variation and forensic efficiency of 19 X-STR loci in the Zhuang and Mulao minorities, we calculated allele frequencies, forensic parameters, and haplotype frequencies of 405 Zhuang and 234 Mulao unrelated healthy individuals from Guangxi Zhuang Autonomous Region of China. Furthermore, we an...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02004-5
更新日期：2020-03-01 00:00:00
abstract：:For over a century, law enforcement agencies, forensic laboratories, and penal courts worldwide have used fingerprint impressions as reliable and conclusive evidence to identify perpetrators of criminal activity. Although fingerprint identification has been repeatedly proven as one of the most robust and definite fore...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0797-0
更新日期：2013-07-01 00:00:00
abstract：:The level of exposure or concealment of a cadaver is known to have an important impact on insect colonisation and decomposition but has been the subject of few investigations. In the present study, 30 pig carcasses were stored in three different types of containers (suitcases, trashcans and drums) with different level...
journal_title：International journal of legal medicine
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doi：10.1007/s00414-019-02089-y
更新日期：2019-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004149900099
更新日期：2000-01-01 00:00:00
abstract：:In cooperation with the Crime Investigation Agency (Landeskriminalamt) of North Rhine-Westphalia, we carried out a study of 150 cases of (suspected) neonaticide dating from 1993 to 2007 from all over Germany. The autopsy reports and additional expert opinions (if performed) were evaluated for a minimum of 78 variables...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0841-8
更新日期：2013-05-01 00:00:00
abstract：:We present a single case report illustrating the diagnostic role of multi-slice computed tomography (MSCT) in the investigation of suspicious child death where mechanical asphyxia is suspected. The case illustrates how radiological findings that may not be observable on conventional plain X-ray were identified by post...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0438-4
更新日期：2010-11-01 00:00:00
abstract：:We propose that clusters of closely linked markers, which segregate as stable haplotypes, provide a high potential to solve complex kinship cases. It is known that the X-chromosomal centromere region shows an extremely low degree of recombination. Hence, we focused our interest on the region between 56 and 64 Mb dista...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0328-9
更新日期：2010-01-01 00:00:00
abstract：:CT scan coupled with autopsy is the gold standard for the forensic investigation of fatal road traffic accidents. The objective of the present paper is to demonstrate that from this, it is possible to reconstruct elements of an accident with minimal human and material resources using basic knowledge of three-dimension...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0789-0
更新日期：2013-09-01 00:00:00
abstract：:It is commonly accepted that crime scene recovery and recording are key moments of any judicial inspection in which investigators must decide on the correct strategies to put into place. Complex outdoor scenarios, presenting partially or entirely skeletonised remains, can benefit more than others by the intervention o...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02456-0
更新日期：2020-12-19 00:00:00
abstract：:Most standard procedures for extracting DNA from forensic substrates involve manipulations that expose the sample to potential contamination and which reduce yields. Furthermore, most methods require centrifugation and/or solvent extraction steps that render them difficult to automate. We describe a simple closed-tube...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-003-0400-9
更新日期：2003-12-01 00:00:00
abstract：:In the present study, blood samples of 984 unrelated Han individuals were collected from Dongfang, Southern China, after informed consent. A total of 29 Y-chromosomal short tandem repeat (Y-STR) were analyzed, including DYF387S1, DYS19, DYS385ab, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS43...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1899-0
更新日期：2019-07-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake in the Results section. The correct equation from the cubic regression analysis for male is: Age = 14.408 + 0.475X-0.064X2 + 0.005X3, and for the female is: 18.196-1.637X + 0.204X2-0.005X3. The error doesn't affect the main conclusion. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00414-017-1751-y
更新日期：2018-01-01 00:00:00
