Organophosphorus pesticide determination in biological specimens: bioanalytical and toxicological aspects.

Abstract:

:Organophosphorus insecticides, such as parathion-ethyl, quinalphos, chlorpyrifos, chlorfenvinphos or diazinon, are still widely used for pest control on crops. These compounds are extremely toxic to humans, and, even though specific legislation exists that controls the use of these substances, the frequency of toxic and/or fatal events and the existing data suggest that they are still easily accessed and the knowledge associated to the risks is not well-recognized. For these reasons, the determination of the exposure to these compounds, their detection (and of their metabolites as well) in biological samples, is of great importance in clinical and forensic toxicology, and, therefore, the development of techniques for this evaluation is an important task for laboratories. Most confirmatory analyses use blood, serum, plasma and urine as biological samples and are performed by either gas chromatographic-mass spectrometric or liquid chromatographic-mass spectrometric instrumentation, which represents the gold standard in what concerns high sensitivity. This paper will not only address the physical-chemical and toxicological aspects of this class of compounds but also perform a comprehensive and critical review on the analytical methods available for their determination in biological specimens, with special focus on the latest instrumental developments and sample preparation approaches.

journal_name

Int J Legal Med

authors

Soares S,Rosado T,Barroso M,Vieira DN,Gallardo E

doi

10.1007/s00414-019-02119-9

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1763-1784

issue

6

eissn

0937-9827

issn

1437-1596

pii

10.1007/s00414-019-02119-9

journal_volume

133

pub_type

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