Abstract：
:Volatile substances are used widespread, especially among young people, as a cheap and easily accessible drug. Tetrachloroethylene is one of the solvents exerting effects on the central nervous system with experiences of disinhibition and euphoria. The case presented is that of a 27-year-old female, found dead by her father at home with cotton swabs dipped in the nostrils. She was already known for this type of abuse and previously admitted twice to the hospital for nonfatal acute poisonings. The swabs were still soaked in tetrachloroethylene. Toxicological and histological investigations demonstrated the presence of an overlap between chronic intake of the substance (with high concentrations in sites of accumulation, e.g., the adipose tissue, and contemporary tissue damage, as histologically highlighted) and acute intoxication as final cause of death, with a concentration of 158 mg/L in cardiac blood and 4915 mg/kg in the adipose tissue. No other drugs or medicines were detected in body fluids or tissues, and to our knowledge, this is the highest concentration ever detected in forensic cases. This peculiar case confirms the toxicity of this substance and focuses on the importance of complete histological and toxicological investigations in the distinction between chronic abuse and acute intoxication.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Amadasi A,Mastroluca L,Marasciuolo L,Caligara M,Sironi L,Gentile G,Zoja Rdoi
10.1007/s00414-015-1143-0subject
Has Abstractpub_date
2015-05-01 00:00:00pages
487-93issue
3eissn
0937-9827issn
1437-1596journal_volume
129pub_type
杂志文章abstract：:Expert witness opinion based on the comparison of images has been accepted by UK courts as admissible evidence in relation to issues of identity. Within images of the hand are a multiplicity of anatomical features of different aetiology, incidence and distribution patterns and this includes melanocytic nevi, referred ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0821-z
更新日期：2014-05-01 00:00:00
abstract：:Gabapentin (GBP) (Neurontin®, Horizant®, Gralise®) is a widely prescribed medication used primarily for the treatment of epilepsy and neuropathic pain. GBP has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and periphera...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1193-3
更新日期：2015-07-01 00:00:00
abstract：:In Japan and elsewhere, ABO genotyping is frequently used in forensic practice for identification of a decomposed body. However, the phenotype deduced from the genotyping data is occasionally inconsistent with the real phenotype. In this paper, we report a simple ABO genotyping method in which five single nucleotide p...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-006-0148-0
更新日期：2008-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02348-3
更新日期：2020-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1500-7
更新日期：2017-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0935-3
更新日期：2014-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1610-x
更新日期：2018-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s00414-016-1330-7
更新日期：2016-03-01 00:00:00
abstract：:A total of 17 Y-specific STR loci were studied in 12 districts of the European part of Russia aiming to ascertain the amount of substructure required for the construction of a representative regional database. All groups exhibited high haplotype diversities but low inter-population variance as measured by an analysis ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-007-0222-2
更新日期：2008-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369906
更新日期：1995-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-006-0139-1
更新日期：2007-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050031
更新日期：1997-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0020-7
更新日期：2006-07-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-021-02504-3
更新日期：2021-01-14 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1641-3
更新日期：2018-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01626039
更新日期：1991-03-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01247266
更新日期：1994-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1008-y
更新日期：2014-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-010-0433-9
更新日期：2010-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1705-4
更新日期：2018-05-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050253
更新日期：1999-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
abstract：:In a Japanese population study of the D1S80 locus 24 alleles ranging from allele 16 to allele43 were analysed using PCR-RFLP. As two repeat units were found to contain the restriction cleavage site (CCAGG) for EcoRII, we digested the alleles with EcoRII, separated the digested fragments on polyacrylamide gels and stai...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050146
更新日期：1998-01-01 00:00:00
