A comparison of 3H-cocaine binding on melanin granules and human hair in vitro.

Abstract:

:The in vitro experiments on the interaction of 3H-cocaine and melanin from Sepia officinalis confirmed the existence of drug binding sites on melanin granules. The results suggested that the binding of 3H-cocaine to melanin could be analyzed by assuming that the binding to the surface of pigment granules is analogous to the adsorption of a drug on a solid and follows Langmuir adsorption isotherm type I. Scatchard analysis indicated heterogeneity of binding sites. Structural and chemical alterations caused by isolation of the melanoproteins, which are heterogeneous in nature and show different physico-chemical properties, are considered to be most crucial. The studies on hair samples confirmed that melanin-drug interaction occur on the surface of melanin granules. These seem to be of minor importance compared to the drug-melanoprotein loading during melanogenesis for the observed influence of pigmentation on the drug content of hair fibers. From the results it was concluded that in vitro studies on melanin provide limited information and even drug-soaked hair must be regarded as inappropriate for the study of melanin-drug-binding in hair.

journal_name

Int J Legal Med

authors

Pötsch L,Skopp G,Rippin G

doi

10.1007/s004140050031

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

55-62

issue

2

eissn

0937-9827

issn

1437-1596

journal_volume

110

pub_type

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