Abstract：
:The in vitro experiments on the interaction of 3H-cocaine and melanin from Sepia officinalis confirmed the existence of drug binding sites on melanin granules. The results suggested that the binding of 3H-cocaine to melanin could be analyzed by assuming that the binding to the surface of pigment granules is analogous to the adsorption of a drug on a solid and follows Langmuir adsorption isotherm type I. Scatchard analysis indicated heterogeneity of binding sites. Structural and chemical alterations caused by isolation of the melanoproteins, which are heterogeneous in nature and show different physico-chemical properties, are considered to be most crucial. The studies on hair samples confirmed that melanin-drug interaction occur on the surface of melanin granules. These seem to be of minor importance compared to the drug-melanoprotein loading during melanogenesis for the observed influence of pigmentation on the drug content of hair fibers. From the results it was concluded that in vitro studies on melanin provide limited information and even drug-soaked hair must be regarded as inappropriate for the study of melanin-drug-binding in hair.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Pötsch L,Skopp G,Rippin Gdoi
10.1007/s004140050031subject
Has Abstractpub_date
1997-01-01 00:00:00pages
55-62issue
2eissn
0937-9827issn
1437-1596journal_volume
110pub_type
杂志文章abstract：:The sequences of the hypervariable region 1 (HV1) of the mitochondrial DNA control region from multiple hair shafts from 10 unrelated individuals were compared to determine the frequency of differences in hairs from one individual. The extraction method described herein showed an average success rate of 67% for all 15...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050226
更新日期：1999-01-01 00:00:00
abstract：:The genetic polymorphisms of 15 autosomal short tandem repeat (STR) loci included in the AmpFISTR Sinofiler™ kit were evaluated in 547 healthy unrelated Han individuals from Gansu, China. All of the loci reached the Hardy-Weinberg equilibrium after the Bonferroni correction (p > 0.0033). These loci were examined to de...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1132-8
更新日期：2015-07-01 00:00:00
abstract：:Short tandem repeats (STRs) are DNA regions with a variable number of repeated units (2-6 bp) and attractive to genetic application like forensic, population genetics, and anthropological studies. The Huaxia Platinum System allows the multiplex amplification of 23 autosomal STR loci and two gender determination loci. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1679-2
更新日期：2018-07-01 00:00:00
abstract：:A study of the genetic variability in the Chueta (Majorcan Jews) and the Balearic (Majorca and Minorca Islands) populations was carried out using a multiplex system containing the nine tetrameric STRs D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317 and D7S820. The Chueta population has remained isolated be...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004149900101
更新日期：2000-01-01 00:00:00
abstract：:Alleles of the STR systems HumFES/FPS, HumVWA and HumD21S11 were sequenced and analyzed. Sequence data revealed 3 different systems concerning the complexity of their sequence structure. HumFES/FPS belongs to the STR polymorphism with a simple repeat structure. Only 2 subtypes were found with a base substitution in th...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01224779
更新日期：1994-01-01 00:00:00
abstract：:CT scan coupled with autopsy is the gold standard for the forensic investigation of fatal road traffic accidents. The objective of the present paper is to demonstrate that from this, it is possible to reconstruct elements of an accident with minimal human and material resources using basic knowledge of three-dimension...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0789-0
更新日期：2013-09-01 00:00:00
abstract：:2-Amino-5-chloropyridine (ACP) is a degradation product of zopiclone (ZOP) and its two main metabolites N-desmethylzopiclone (NDZOP) and zopiclone N-oxide (ZOPNO). ACP may be formed when specimens are stored. ZOP instability in blood makes interpretation of concentrations difficult especially in cases of prolonged sam...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1049-2
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:The aim of this multi-reader feasibility study was to evaluate new post-processing CT imaging tools in rib fracture assessment of forensic cases by analyzing detection time and diagnostic accuracy. MATERIALS AND METHODS:Thirty autopsy cases (20 with and 10 without rib fractures in autopsy) were randomly select...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1412-6
更新日期：2017-03-01 00:00:00
abstract：:We investigated control and coding region polymorphisms in mitochondrial DNA (mtDNA) in 100 unrelated individuals from a Japanese population and determined the basal phylogenetic haplogroup lineages in all samples under updated information. Many of the basal phylogenetic haplogroup lineages assigned on East Asian mtDN...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0308-5
更新日期：2010-01-01 00:00:00
abstract：:In order to establish a reliable age indicator in the period when all other epiphyseal age indicators have already been inactivated, medial clavicle as the bone with the longest period of growth became the object of various investigations. However, the lack of population-specific method often made it unreliable in som...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0791-6
更新日期：2013-05-01 00:00:00
abstract：:Various aspects concerning the practical application and forensic interpretation of data obtained by saliva drug testing and drug monitoring from the skin surface are discussed. Basic information on the composition of saliva and skin secretions and their particular transport mechanisms, as far as known, are given. For...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s004140050239
更新日期：1999-01-01 00:00:00
abstract：:The use of DNA to determine the ancestry of an individual is becoming more and more important in the areas of forensics. Kidd et al. (Forensic Sci Int Genet 12:215-224, 2014) have been the first to identify and catalog haplotypes, termed as minihaplotypes (1-10-kilobase spans) and microhaplotypes (≤ 200 bp), with pote...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1881-x
更新日期：2019-07-01 00:00:00
abstract：:Myocardial pathology and cardiac functional abnormalities known to occur in association with chronic alcohol abuse have been attributed to a direct toxic effect of ethanol on the intra-myocardial vasculature: alcohol-induced occlusion of small arteries with consequent secondary ischaemia leads to individual myocyte lo...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01225513
更新日期：1996-01-01 00:00:00
abstract：:Article 25 of the Charter of Fundamental Rights of the European Union (adopted in Nice on 7 December 2000) recognizes and respects the rights of older people to lead a life of dignity and independence and to participate in social and cultural life. It also highlights the importance of prevention and recognition of eld...
journal_title：International journal of legal medicine
pub_type： 杂志文章,实务指引
doi：10.1007/s00414-018-1880-y
更新日期：2019-01-01 00:00:00
abstract：:A case of traumatic cervical spinal cord injury due to congenital craniocervical abnormalities is described. The autopsy revealed evidence of hyperextension of the neck due to frontal impact, congenital occipitalization of the atlas accompanied by basilar invagination of the odontoid process and atlanto-axial diastasi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01225023
更新日期：1993-01-01 00:00:00
abstract：:Anthropologists are constantly seeking to improve methods for age estimation in the human skeleton. A new method was introduced about a decade ago that assesses the morphological changes that take place in the acetabulum as an individual ages. The pelvis is usually well preserved in forensic cases, which makes this me...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1299-7
更新日期：2016-05-01 00:00:00
abstract：:The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0404-1
更新日期：2011-01-01 00:00:00
abstract：:Sudden infant death syndrome is the unexpected demise of a child younger than 1 year of age which remains unexplained after a complete autopsy investigation. Usually, it occurs during sleep, in males, and during the first 12 weeks of life. The pathophysiological mechanism underlying the death is unknown, and the letha...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s00414-016-1330-7
更新日期：2016-03-01 00:00:00
abstract：:The purpose of the present research is to study the radiographic visibility of the periodontal ligament in third molars from a northern Chinese population to determine if this methodology could be used for the 18-year threshold. A total of 1300 conventional orthopantomograms from 650 males and 650 females of northern ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1664-9
更新日期：2018-03-01 00:00:00
abstract：:A short tandem repeat at the D1S1656 locus was sequenced in 45 selected alleles and 13 different alleles were found which were designated according to the total number of repeats. This STR is a compound hypervariable STR consisting of blocks of (TAGR) repeats with a basic sequence structure (TAGA)4(TGA)0-1(TAGA)6-16(T...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050161
更新日期：1998-01-01 00:00:00
abstract：:The estimation of the minimum postmortem interval can be implemented by age estimation of corpse-associated primary colonizers such as the blow flies (Diptera: Calliphoridae). In cases where pupae represent the oldest stages found on a body, their age must be added to the duration of prepupal development to estimate t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0922-8
更新日期：2014-05-01 00:00:00
abstract：:Myocardial infarctions go along with biomechanical stress, i.e. stretching of muscle fibres, and the expression of certain marker molecules. We tested if two of those markers, endothelin-1 (ET-1) and growth differentiation factor 15 (GDF-15), can be used as immunohistochemical markers for myocardial ischaemia/infarcti...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1726-z
更新日期：2018-03-01 00:00:00
abstract：:A medicolegal/algological collaboration lasting several years aimed at developing methods for dealing with dead bodies found in water where the circumstances are not clear, has led to an interdisciplinary procedure. To enable algological analysis, sample preservation and preparation must be free from contamination or ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s004149900122
更新日期：2000-01-01 00:00:00
abstract：:The case concerns the sudden death of a 21-year-old male during a soccer game. The autopsy revealed large, calcified saccular aneurysms at the origins of both the left anterior descending and the right coronary arteries. Histologically, the wall of the aneurysms was thin and composed of an internal fibro-calcified lay...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050213
更新日期：1999-01-01 00:00:00
abstract：:Genetic diversity indices and forensic parameters at 20 autosomal short tandem repeat (STR) loci were evaluated in 233 unrelated individuals of Himachal Pradesh, India. In total, 255 alleles were observed with an average of 11.25 ± 0.88 alleles per locus. None of the loci deviated from Hardy Weinberg Equilibrium. The ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02254-8
更新日期：2020-09-01 00:00:00
abstract：:We demonstrate the applicability of ion-pair reversed-phase high-performance liquid chromatography-electrospray ionization time-of-flight mass spectrometry (ICEMS) for the simultaneous characterization of length and nucleotide polymorphisms. Two sections within the first (HVS-I) and second (HVS-II) hypervariable segme...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-006-0117-7
更新日期：2007-01-01 00:00:00
abstract：:ABO blood grouping of human bloodstains was performed by a sandwich ELISA using a species-specific monoclonal antibody to the amino-terminal cytoplasmic domain of human red cell membrane band 3. In a blind trial, all A, B and O bloodstains (a 1 cm long thread) and AB bloodstains (a 1.5 cm long thread) were accurately ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01642795
更新日期：1993-01-01 00:00:00
abstract：:The original version of this article contained an author name error. In this article, Katrina Madella has been corrected to Katrina Maddela. ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00414-019-02031-2
更新日期：2019-05-01 00:00:00
abstract：:In humans, the amelogenin gene is present on both the X and the Y chromosomes. However, there are size differences in this gene between these chromosomes, which have been utilised for sexing in forensic casework and prenatal diagnosis. Our study using the AmpFl STR Profiler Plus kit, showed a deletion of Y chromosome-...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-001-0262-y
更新日期：2002-04-01 00:00:00
abstract：:A case report of a 25-year-old man who committed suicide by intravenous injection himself of an aqueous home-made castor bean extract is presented. The patient was hospitalized and treated symptomatically and was released at its own request fourth day after intoxication. The next day, the patient's condition deteriora...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02340-x
更新日期：2020-11-01 00:00:00
