Abstract：
:Gabapentin (GBP) (Neurontin®, Horizant®, Gralise®) is a widely prescribed medication used primarily for the treatment of epilepsy and neuropathic pain. GBP has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and peripheral edema. Even with intentional GBP self-poisonings, serious effects are rare. A 47-year-old female was found dead at work with her daughter's bottle of GBP 600 mg. There were 26 tablets missing and the decedent's only known medication was hydrocodone/acetaminophen. Following initial detection by an alkaline drug screen (GC-MS), analysis utilizing specific liquid chromatography-mass spectrometry revealed an elevated postmortem GBP peripheral blood concentration of 37 mg/L, central blood 32 mg/L, liver 26 mg/kg, vitreous 32 mg/L, and gastric contents 6 mg. Screening for volatiles, drugs of abuse, alkaline compounds, and acid/neutral compounds was negative with the exception of ibuprofen (<2 mg/L) detected in peripheral blood. This report presents a fatality that appears to be associated with an isolated and acute GBP ingestion.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Cantrell FL,Mena O,Gary RD,McIntyre IMdoi
10.1007/s00414-015-1193-3subject
Has Abstractpub_date
2015-07-01 00:00:00pages
771-5issue
4eissn
0937-9827issn
1437-1596journal_volume
129pub_type
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369714
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abstract：:Lactate dehydrogenase isoenzyme patterns indicative of vaginal injury were identified in extracts of a bloodstain on a pair of knickers belonging to a 4-year-old girl. No evidence of semen or saliva was detected in the stain. The result corroborated the clinical findings and provided strong evidence of child sexual ab...
journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2010-09-01 00:00:00
abstract：:The systemic distribution of kerosene components in blood and tissues was analysed in rats following dermal exposure. Four types of trimethylbenzenes (TMBs) and aliphatic hydrocarbons (AHCs) with carbon numbers 9-16 (C(9)-C(16)) were analysed as major kerosene components by capillary gas chromatography/mass spectromet...
journal_title：International journal of legal medicine
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更新日期：2002-08-01 00:00:00
abstract：:This paper considers the statistical evaluation of DNA mixtures in the following situations: (1) two unknown contributors are related respectively to two typed persons, (2) two of the unknown or untyped contributors are related and the third unknown contributor is related to a typed person, or (3) there are two pairs ...
journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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doi：10.1007/s00414-012-0671-0
更新日期：2012-07-01 00:00:00
abstract：:Sudden infant death syndrome (SIDS) is a target for public health care in Germany. The aim of this study was to monitor data on risk-related behavior in the population of Hamburg, Germany, in order to respond to changes quickly and to estimate the effectiveness of prevention activities. Data have been gathered using t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0298-3
更新日期：2009-01-01 00:00:00
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journal_title：International journal of legal medicine
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doi：10.1007/s00414-008-0273-z
更新日期：2008-11-01 00:00:00
abstract：:The allelic frequency distributions and statistical forensic parameters of 26 mini short tandem repeat (mini-STR) loci in a sample of 1575 unrelated individuals from five different Brazilian regions were obtained. All the analyzed loci showed great diversity and were highly informative. The results were compared with ...
journal_title：International journal of legal medicine
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更新日期：2018-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01222119
更新日期：1993-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1138-2
更新日期：2015-03-01 00:00:00
abstract：:Estimation of age in individuals has received considerable attention in the forensic literature. The reduction of size of dental pulp cavity as a result of secondary dentin deposit with increasing age could be used as an indicator of age. This regression change, apart from morphological techniques, can also be analyse...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0268-9
更新日期：2009-03-01 00:00:00
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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更新日期：2013-09-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：International journal of legal medicine
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doi：10.1007/s00414-015-1219-x
更新日期：2016-07-01 00:00:00
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journal_title：International journal of legal medicine
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of legal medicine
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更新日期：2018-03-01 00:00:00
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journal_title：International journal of legal medicine
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更新日期：2021-01-27 00:00:00
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
abstract：:Paradoxical undressing is a phenomenon characterizing some fatal hypothermia cases. The victims, despite low environmental temperatures, paradoxically remove their clothes due to a sudden feeling of warmth. In this report, we describe a case of suspected paradoxical undressing in a non-hypothermia case. The victim, a ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1597-3
更新日期：2017-09-01 00:00:00
