Abstract：
:DNA-based prediction for externally visible characteristics such as eye color is already a useful tool in forensic criminal investigations. The IrisPlex system, consisting of six single nucleotide polymorphisms (SNPs) and a prediction model, was developed based on individuals from several European populations. Other recent studies have developed a different prediction model, also based on European populations. In this study, we compared two prediction models using the data for the six IrisPlex SNPs genotyped on 905 individuals from 12 different Eurasian populations. All SNPs showed significant differences in allele frequencies among three groups of populations: European, genetically intermediate (Khanty, Uygur, and Yakut), and East Asian. The two prediction models, the FROG-kb calculation based on the formula of Walsh et al. (2011) and the Snipper calculation from Ruiz et al. (2013), gave identical predictions of brown eye color for the four East Asian populations with complete data but did not give concordant predictions for many individuals in the seven intermediate and European populations. Inconsistencies were mainly conclusive prediction by one model but not the other. Of the 714 individuals with complete 6-locus genotypes, the two models gave 22 % inconsistent predictions. Eliminating the 306 individuals in the Korean and three Chinese populations, in which the predictions were always consistent for brown eye color, the inconsistencies (among the remaining 408 individuals) were 38.7 %. We conclude that more attention should be paid to predictive uncertainty/error. Implementation of both prediction models in future forensic casework is one immediate way to highlight uncertainty.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Yun L,Gu Y,Rajeevan H,Kidd KKdoi
10.1007/s00414-013-0953-1subject
Has Abstractpub_date
2014-05-01 00:00:00pages
447-53issue
3eissn
0937-9827issn
1437-1596journal_volume
128pub_type
杂志文章abstract：:The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
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更新日期：1993-01-01 00:00:00
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journal_title：International journal of legal medicine
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01245481
更新日期：1995-01-01 00:00:00
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更新日期：2009-09-01 00:00:00
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更新日期：2005-07-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
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journal_title：International journal of legal medicine
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doi：10.1007/s00414-018-1802-z
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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journal_title：International journal of legal medicine
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更新日期：2021-01-23 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01845611
更新日期：1995-01-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：International journal of legal medicine
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1990-12-01 00:00:00
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journal_title：International journal of legal medicine
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doi：10.1007/BF01225046
更新日期：1993-01-01 00:00:00
