Abstract：
:Contrary to the traditional dogma of being a relatively invariable and quiescent organ lacking the capability to regenerate, there is now widespread evidence that the human brain harbors multipotent neural stem cells, possibly throughout senescence. These cells can divide and give rise to neuroectodermal progeny in vivo and are now regarded as powerful prospective candidates for repairing or enhancing the functional capability of neural tissue in trauma or diseases associated with degeneration or malperfusion. Hopes primarily rest upon techniques to either recruit endogenous stem cells or to utilize exogenous donor-derived material for transplantation. In the search for suitable human cell sources, embryonic, fetal, and adult stem cells appear highly controversial, as they are accompanied by various still-unresolved moral and legal challenges. Fascinatingly, however, recent reports indicate the successful isolation and expansion of viable neural stem cells from the rodent and human brain within a considerable postmortem interval, suggesting that postmortem neural stem cells could potentially become an acceptable alternative cellular resource. This article will provide a brief overview about neural stem cells, their prominent features, and prospects for a cellular therapy, and will furthermore illuminate the cells in particular with respect to their newly discovered postmortem provenience, their advantage as a potential cell source, and several unfolding forensic considerations. Also, important ethical, social, and legal implications arising from this hitherto unpracticed cellular harvest of brain tissue from the deceased are outlined.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Feldmann RE Jr,Mattern Rdoi
10.1007/s00414-005-0037-ysubject
Has Abstractpub_date
2006-07-01 00:00:00pages
201-11issue
4eissn
0937-9827issn
1437-1596journal_volume
120pub_type
杂志文章,评审abstract：:A case of rupture of the superior mesenteric vein with hemoretroperitoneum is described. The autopsy revealed the presence of an acute pancreatitis and thrombosis of the superior mesenteric artery. From the histological findings it appeared that the acute pancreatitis had damaged the venous wall from the outside and t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369553
更新日期：1992-01-01 00:00:00
abstract：:We have studied the correlation between the level of D-aspartic acid in dentin and the period of dentin formation in different types of teeth from the same individual. Except for the third molar, it is generally agreed that the formation of permanent dentin follows the pattern of growth, occurring earliest in the firs...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-003-0365-8
更新日期：2003-06-01 00:00:00
abstract：:A block of an injury instrument will be left in wounds sometimes, and the suspect instrument can be discriminated by comparison with the block that was left through elemental analysis. In this study, three brands (Shibazi, Zhangxiaoquan, Qiaoxifu) of kitchen knives with forged, chop, and slice application series were ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0829-4
更新日期：2014-03-01 00:00:00
abstract：:A 49-year-old white male was found lying unconscious at home. He had vomited, his mouth was filled with a white foam and a pungent odour filled the room. After emergency treatment blood, urine and stomach contents were screened for drugs after acid and alkaline extraction with subsequent derivatisation and GC-MS analy...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050080
更新日期：1997-01-01 00:00:00
abstract：:Scars of human skin can on occasions provide a very useful ancillary method of identification of an unknown deceased. If the age of any visible scars can be estimated objectively, then this might be of some assistance in the identification procedure. Melanocytes migrate into scar tissue as it ages and their number wit...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140100225
更新日期：2001-10-01 00:00:00
abstract：:We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 %. The diversity values ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0705-7
更新日期：2012-07-01 00:00:00
abstract：:Using AGCU Y24 Plus PCR Amplification Kit, 32 Y short tandem repeat (STR) loci were analyzed in 355 unrelated male participants of Meizhou city in Guangdong Province of China. By analyzing 341 different haplotypes, it was found that haplotype diversity (HD) and discrimination capacity (DC) were 0.9995 and 0.9605, resp...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1845-1
更新日期：2019-03-01 00:00:00
abstract：:The use of DNA to determine the ancestry of an individual is becoming more and more important in the areas of forensics. Kidd et al. (Forensic Sci Int Genet 12:215-224, 2014) have been the first to identify and catalog haplotypes, termed as minihaplotypes (1-10-kilobase spans) and microhaplotypes (≤ 200 bp), with pote...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1881-x
更新日期：2019-07-01 00:00:00
abstract：:Limited genetic marker information can be obtained from saliva by typing by conventional serological means. Thus, the application of PCR-based DNA typing methods was investigated as a potential approach for typing genetic markers in saliva. DNA was isolated from 200 cigarettes smoked by 10 different individuals (20 ci...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369812
更新日期：1991-01-01 00:00:00
abstract：:The purpose of this study was to explore the applicability of periodontal ligament visibility (PLV) at the 18-year threshold. This mandibular maturity marker is graded into four separate age related stages, PLV-A, PLV-B, PLV-C, and PLV-D. These are discernible on a dental panoramic tomograph (DPT). The sample comprise...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1468-3
更新日期：2017-05-01 00:00:00
abstract：:A total of 34 deployed driver and passenger airbags from altogether 20 vehicles after frontal collisions were investigated. In 80% of the airbags possible biological traces could be located with an alternative light source (ALS, Polilight) at a wavelength of 450-470 nm. These traces were swabbed, a part of them additi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-003-0406-3
更新日期：2004-02-01 00:00:00
abstract：:The allelic frequency distributions and statistical forensic parameters of 26 mini short tandem repeat (mini-STR) loci in a sample of 1575 unrelated individuals from five different Brazilian regions were obtained. All the analyzed loci showed great diversity and were highly informative. The results were compared with ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1777-9
更新日期：2018-09-01 00:00:00
abstract：:In a knife attack the perpetrator can unintentionally injure his own hand, if the knife does not have an adequate handguard and the tip of the blade hits a solid, mostly bony structure while being violently thrust into the victim's body. The injuries occurring under these conditions are localized on the flexor side of...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0491-y
更新日期：2004-12-01 00:00:00
abstract：INTRODUCTION:The determination of age of majority (the 18-year-old threshold) using the popular Demirjian tooth staging method is unreliable, so other maturity markers are required. This study examines whether the Root Pulp Visibility (RPV) of the mandibular third molar is a useful indicator of age. METHODS:One thousa...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02155-5
更新日期：2020-01-01 00:00:00
abstract：:Backspatter is the ejection of biological material from a gunshot entrance wound against the line of fire. This phenomenon was investigated experimentally in transverse gunshots to the heads of calves (n = 9) using two types of 9 mm Parabellum ammunition from shooting distances of 0-10 cm. The resulting bloodstains we...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01355519
更新日期：1996-01-01 00:00:00
abstract：INTRODUCTION:The impact of socioeconomic status (SES) on tooth mineralization has seldom been evaluated. This is important because SES can be used as a proxy for quantifying factors in the environmental that can impact mineralization but that can be difficult to measure directly, such as nutrition. OBJECTIVE:The objec...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-016-1476-3
更新日期：2017-01-01 00:00:00
abstract：:Stabbing with a kitchen knife is a common method of homicide in Europe. Serrated knives may leave tool markings (striations) in tissues. Documentation of striations is necessary for their use as forensic evidence. Traditional methods (physical casting and photography) have significant limitations, and micro-computed t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1715-2
更新日期：2018-03-01 00:00:00
abstract：:For over a century, law enforcement agencies, forensic laboratories, and penal courts worldwide have used fingerprint impressions as reliable and conclusive evidence to identify perpetrators of criminal activity. Although fingerprint identification has been repeatedly proven as one of the most robust and definite fore...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0797-0
更新日期：2013-07-01 00:00:00
abstract：:In this casuistry, two accidents from Germany and Switzerland are presented that happened during the shot of recoilless anti-tank weapons. In both cases, the injuries led to the death of two soldiers: A 22-year-old soldier in Germany was struck by the counter mass of a so-called Davis gun which had been fired by a com...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02301-4
更新日期：2020-11-01 00:00:00
abstract：:In the forensic anthropology practice, bone diseases are rarely considered for personal identification. In this paper, we present a forensic skeletonized case with tuberculous bone lesions, for which bone pathology may provide an indicator for positive personal identification. Antemortem hospital records were availabl...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02348-3
更新日期：2020-09-01 00:00:00
abstract：:Expert witness opinion based on the comparison of images has been accepted by UK courts as admissible evidence in relation to issues of identity. Within images of the hand are a multiplicity of anatomical features of different aetiology, incidence and distribution patterns and this includes melanocytic nevi, referred ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0821-z
更新日期：2014-05-01 00:00:00
abstract：:Sudden infant death syndrome is the unexpected demise of a child younger than 1 year of age which remains unexplained after a complete autopsy investigation. Usually, it occurs during sleep, in males, and during the first 12 weeks of life. The pathophysiological mechanism underlying the death is unknown, and the letha...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s00414-016-1330-7
更新日期：2016-03-01 00:00:00
abstract：:It is difficult to carry out toxicological investigations in biological samples collected from extensively decomposed bodies and to interpret obtained results as several pitfalls should be considered: redistribution phenomena, degradation of xenobiotics during the postmortem period, contamination by putrefaction fluid...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02267-3
更新日期：2020-07-01 00:00:00
abstract：:Current analysis of forensic DNA stains relies on the probabilistic interpretation of bulk-processed samples that represent mixed profiles consisting of an unknown number of potentially partial representations of each contributor. Single-cell methods, in contrast, offer a solution to the forensic DNA mixture problem b...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-021-02503-4
更新日期：2021-01-23 00:00:00
abstract：:Recent studies show that ethyl glucuronide (EtG) can be decomposed by bacteria; whilst so far no degradation of ethyl sulphate (EtS) has been observed. In the present study, in vitro experiments with bacterial colonies were performed. Bacteria (Escherichia coli, Klebsiella pneumoniae, Clostridium sordellii) were isola...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0229-3
更新日期：2008-09-01 00:00:00
abstract：:In three separate shooting incidents involving multiple gunshots, two FMJ bullets and one bullet fragment found at the scene (one from each case) were investigated for the presence of biological material from the victim after perforation. The surface of the missiles, which did not show obvious tissue traces when exami...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050041
更新日期：1997-01-01 00:00:00
abstract：:The forensic application of mtDNA typing requires large databases which are regionally well defined. To further this aim, we have typed mtDNA in a sample of 111 French and 106 Sicilians. The French were typed for both hypervariable segments (HVR1 and HVR2) of the mtDNA control region, whereas the Sicilians were only t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140000169
更新日期：2001-01-01 00:00:00
abstract：:DNA profiles from degraded samples often suffer from information loss at the longer short tandem repeat (STR) loci. Sensitising the reactions, either by performing additional PCR cycles or increasing the capillary electrophoresis injection settings, carries the risk of over-amplifying or overloading the shorter fragme...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0816-1
更新日期：2013-07-01 00:00:00
abstract：:Organophosphorus insecticides, such as parathion-ethyl, quinalphos, chlorpyrifos, chlorfenvinphos or diazinon, are still widely used for pest control on crops. These compounds are extremely toxic to humans, and, even though specific legislation exists that controls the use of these substances, the frequency of toxic a...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s00414-019-02119-9
更新日期：2019-11-01 00:00:00
abstract：:We demonstrate the applicability of ion-pair reversed-phase high-performance liquid chromatography-electrospray ionization time-of-flight mass spectrometry (ICEMS) for the simultaneous characterization of length and nucleotide polymorphisms. Two sections within the first (HVS-I) and second (HVS-II) hypervariable segme...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-006-0117-7
更新日期：2007-01-01 00:00:00
