Abstract：
:Methadone plays an increasing role in drug-related deaths in Hamburg. To find out whether intravenous application of methadone plays a relevant role in methadone-related deaths, body fluids of all methadone-positive cases (n=130) and three buprenorphine-positive cases where a urine sample was available (n=58+3) were investigated for disaccharides (sucrose and lactose as markers for intravenous methadone abuse). Sixty-four percent of the urine samples of the methadone cases showed positive results for disaccharides (22 times sucrose alone, range 2 to >1,000 mg/L; 6 times lactose and sucrose; and 9 times lactose alone, range 22 to 382 mg/L). The three buprenorphine cases showed positive results for lactose in urine. In blood, it was not possible to detect any disaccharides. Of the 116 fatal methadone intoxications, 49 % were under opiate maintenance treatment (OMT) at the point of death (A-OMT), 30 % were never in OMT (N-OMT) and 21 % were formerly in an OMT, but not at the point of death (F-OMT). Of the deceased in the OMT group, 12 % (n=7) died within the first 2 weeks of treatment, six of them within the first week. Overall, intravenous abuse of methadone plays a relevant role in methadone-related fatal cases of substituted patients and of drug consumers not in therapy. Thus, it is necessary that therapists keep to the statutory regulations and give take-home doses only after at least 6 months of successful therapy and when there is no suspicion of intravenous abuse.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Iwersen-Bergmann S,Jungen H,Andresen-Streichert H,Müller A,Elakkary S,Püschel K,Heinemann Adoi
10.1007/s00414-014-1017-xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
751-64issue
5eissn
0937-9827issn
1437-1596journal_volume
128pub_type
杂志文章abstract：:Brazilian population derives from Native Amerindians, Europeans, and Africans. Southeastern Brazil is the most populous region of the country. The present study intended to characterize the maternal genetic ancestry of 290 individuals from southeastern (Brazil) population. Thus, we made the sequencing of the three hyp...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1023-z
更新日期：2014-07-01 00:00:00
abstract：:This study presents the application of Y-chromosomal STR polymorphisms to male identification in the case of a serial rapist and woman murderer in Poland. Since August 1996 a rapist from Swinoujscie (northwest Poland) committed at least 14 rapes. In the year 2000 he brutally raped 8 young girls and murdered a 22-year-...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-002-0320-0
更新日期：2002-10-01 00:00:00
abstract：:A chimera is an organism whose cells derive from two or more distinct zygote lineages. and therefore two different blood cell populations circulate in one individual. To point out the potential pitfalls in forensic analysis, a set of triplets (a girl and two boys) who revealed blood chimerism was investigated with fou...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050263
更新日期：1999-01-01 00:00:00
abstract：:Forensic age estimation of living individuals has become increasingly important in forensic practice with the constant increase of migration movements to developed countries. The method of Greulich and Pyle is one of the most frequently used methods for age determination. The aim of our study was to verify the reliabi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1028-7
更新日期：2015-01-01 00:00:00
abstract：:Age estimation in living individuals around the age of 18 years remains a difficult challenge. In this study, the anterior inferior vertebral ring apophysis development of cervical vertebrae C2, C3, and C4 of 496 white and 478 black South African individuals aged between 15 and 22 years was assessed from cephalometric...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02137-7
更新日期：2019-11-01 00:00:00
abstract：:To increase the reliability of forensic age estimations in living adolescents and young adults where there is no legitimation for X-ray examinations, it would be desirable to establish radiation-free imaging methods. In the present study, the ossification stage of the distal femoral epiphysis was determined retrospect...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-0967-3
更新日期：2014-05-01 00:00:00
abstract：:During the testing of alternative primers for the Y chromosome short tandem repeat marker DYS19, a duplicated region of the Y chromosome was discovered. The duplicated sequence is contained within GenBank accession AC006335 and has a high degree of homology with the DYS19 flanking region (GenBank accession AC017019) b...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0436-5
更新日期：2004-06-01 00:00:00
abstract：:The utility of postmortem microbiology has continuously been a topic of controversy. The present study describes a case of fatal sepsis in a patient with systemic lupus erythematosus. Postmortem culture and genotyping analyses allowed us to identify Klebsiella pneumoniae as the cause of sepsis, revealing the inadequat...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1160-z
更新日期：2015-09-01 00:00:00
abstract：:Allele frequencies of 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA) were determined in a sample of 163 unrelated individuals from the Republic of Macedonia. AmpFISTR Identifiler Kit (Applied Biosystems) was used for PCR amplificatio...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0025-2
更新日期：2006-01-01 00:00:00
abstract：:The aim of this study was to measure catecholamines and their O-methylated metabolites in urine and vitreous humor collected in cardiac deaths and noncardiac control cases that underwent medicolegal investigations. Our first goal was to assess whether cardiac events of different types are characterized by different ca...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1303-2
更新日期：2016-07-01 00:00:00
abstract：:A short tandem repeat at the D1S1656 locus was sequenced in 45 selected alleles and 13 different alleles were found which were designated according to the total number of repeats. This STR is a compound hypervariable STR consisting of blocks of (TAGR) repeats with a basic sequence structure (TAGA)4(TGA)0-1(TAGA)6-16(T...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050161
更新日期：1998-01-01 00:00:00
abstract：:BamHI polymorphism at the VNTR locus D2S44 was investigated, concentrating on band frequencies, mutation rate and confirmation of Mendelian inheritance. In this series 39 restriction fragments showing frequencies less than 10% could clearly be distinguished. No mutations could be observed and the Mendelian character o...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01816481
更新日期：1990-12-01 00:00:00
abstract：:Qualitative information on the sequence composition of the allele and locus structure of the X-STRs DXS8378, DXS9898, DXS6789, GATA31E08, and GATA172D05 was generated in this study. Sequence data were obtained from chimpanzees (Pan troglodytes) and diverse human population groups including Africans, Caucasians, Asians...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0303-x
更新日期：2009-03-01 00:00:00
abstract：:Five short tandem repeat (STR) systems HumVWA, HumTH01, HumCD4, HumF13B and HumFES were investigated in 2 subpopulations living in Turkey (Laz Turks and Kurds). The population genetic data were compared to a Turkish population sample from the Adana area. A closer genetic relationship was found to the Laz Turks than to...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050059
更新日期：1997-01-01 00:00:00
abstract：:Messenger RNA (mRNA) markers have been extensively investigated for the identification of forensically relevant body fluids and tissues based on their expression profiles among cell types. As products of the backsplicing of pre-mRNAs, circular RNAs (circRNAs) share exonic sequences with their linear counterparts. The ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-019-02027-y
更新日期：2019-09-01 00:00:00
abstract：:In forensic science, the unequivocal identification of the cellular origin of crime scene samples used for DNA profiling can provide crucial information for crime scene reconstruction. We have previously shown that various mRNA markers from genes with expression patterns specific for blood and saliva can be establishe...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0249-z
更新日期：2009-01-01 00:00:00
abstract：:Advances in forensic identification using molecular genetics are helpful in resolving some historical mysteries. The aim of this study was to confirm the authenticity of shrunken-head artifacts exhibited by two Polish museums. Shrunken heads, known as tsantsas, were headhunting trophies of South American Indians (Jiva...
journal_title：International journal of legal medicine
pub_type： 历史文章,杂志文章
doi：10.1007/s00414-016-1448-7
更新日期：2017-05-01 00:00:00
abstract：:One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be propose...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1781-0
更新日期：2018-09-01 00:00:00
abstract：:Sexual assault is a complex situation with medical, psychological, and legal aspects. Forensic experts play a major role in terms of forensic and gynecological medical examination and evidence collection in order to maintain the chain of custody. Victims should be examined by a specially trained medico-legal examiner ...
journal_title：International journal of legal medicine
pub_type： 杂志文章,实务指引
doi：10.1007/s00414-018-1791-y
更新日期：2018-11-01 00:00:00
abstract：:Acute aortic dissection (AAD) is a clinically "silent," but emergent and life-threatening cardiovascular disease, and hereditary factors play an important etiologic role in the development of AAD. The purposes of this study are to definitize the diagnostic yield of 59 AAD patients, investigate the molecular pathologic...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-018-1890-9
更新日期：2018-09-01 00:00:00
abstract：:Hereditary hemochromatosis (HH) is a frequent autosomal recessive disease which causes iron-overload of various organs. Of all northern European affected individuals, 90-95% show 1 of 3 known point mutations in the HFE gene. Symptoms and organs involved can vary considerably: Only a small fraction of the 200,000-400,0...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0451-6
更新日期：2004-06-01 00:00:00
abstract：:Frontal sinuses are of special interest for personal identification thanks to their high variability. A common procedure for comparing ante-mortem and post-mortem material is based on coding systems classifying frontal sinuses according to their morphological and metrical characteristics. However, the calculation of p...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02293-1
更新日期：2020-09-01 00:00:00
abstract：:The estimation of the minimum postmortem interval can be implemented by age estimation of corpse-associated primary colonizers such as the blow flies (Diptera: Calliphoridae). In cases where pupae represent the oldest stages found on a body, their age must be added to the duration of prepupal development to estimate t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0922-8
更新日期：2014-05-01 00:00:00
abstract：AIM:To determine the frequency of cardiopulmonary resuscitation (CPR)-related injuries and factors involved in their occurrence, data based on forensic autopsy and postmortem computed tomography (PMCT) during implementation of the 2010 American Heart Association Guidelines for CPR were studied. METHODS:We retrospectiv...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1673-8
更新日期：2017-11-01 00:00:00
abstract：:The hypothesis that antitussives containing ethylmorphine are abused by alcoholics and drug addicts and that this may lead to fatal poisonings where ethylmorphine causes or contributes to death was investigated. For this purpose 14 cases were analysed where a blood ethylmorphine concentration above the therapeutic lev...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050253
更新日期：1999-01-01 00:00:00
abstract：:(-)-Δ-9-tetrahydrocannabinol ((-)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (-)-11-hydroxy-Δ-9-tetrahydrocannabinol ((-)-11-OH-Δ-9-THC), which is psychoactive, and to (-)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol ((-)-Δ-9-THC-COOH), which is psychoinacti...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02387-w
更新日期：2020-11-01 00:00:00
abstract：:In kinship analysis, large data sets with estimated haplotype frequencies for marker clusters are very important for the likelihood calculation. Practical use of the X-STRs demonstrated that in some complex kinship cases, the marker set of the Investigator Argus X-12 kit can be insufficient. This study aimed to extend...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02306-z
更新日期：2020-11-01 00:00:00
abstract：:The purpose of this study is to evaluate allelic association and linkage of 18 adjacent syntenic short tandem repeat (STR) pairs form out of 30 markers located on 12 different autosomes. Linkage disequilibrium was tested by using the unknown gametic phase genotypes and phased haplotypes from 290 unrelated individuals ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-014-1032-y
更新日期：2014-09-01 00:00:00
abstract：:The question of whether an individual has reached the age of 18 is of crucial importance in forensic age estimation practice. In some countries, the age threshold of 21 years is relevant as well. A completed mineralization of third molars is not a sufficient criterion for a diagnosis of a minimum age of 18 years with ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0415-y
更新日期：2010-05-01 00:00:00
abstract：:For over a century, law enforcement agencies, forensic laboratories, and penal courts worldwide have used fingerprint impressions as reliable and conclusive evidence to identify perpetrators of criminal activity. Although fingerprint identification has been repeatedly proven as one of the most robust and definite fore...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0797-0
更新日期：2013-07-01 00:00:00
