DNA typing in cases of blood chimerism.

Abstract:

:A chimera is an organism whose cells derive from two or more distinct zygote lineages. and therefore two different blood cell populations circulate in one individual. To point out the potential pitfalls in forensic analysis, a set of triplets (a girl and two boys) who revealed blood chimerism was investigated with four STR systems using PCR. The results indicated that a DNA profile based on DNA extracted from blood can lead to a false determination because the band pattern of each triplet contained a mixture of the original genotype and the genotype of the siblings. Additional investigations on biological materials other than blood must be made in order to find out the real genetic characteristics of each child.

journal_name

Int J Legal Med

authors

Milde A,Kühl-Burmeister R,Ritz-Timme S,Kaatsch HJ

doi

10.1007/s004140050263

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

333-5

issue

5

eissn

0937-9827

issn

1437-1596

pii

91120333.414

journal_volume

112

pub_type

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