Abstract：
:Growth arrest-specific 6 (Gas6) is widely expressed in leukocytes, platelets, endothelial cells, and monocytes. It regulates various processes including granulocyte adhesion to the endothelium, cell migration, thrombus stabilization, and cytokine release. In humans, increased plasma Gas6 levels have been described in patients with sepsis and septic shock. In this study, Gas6 concentrations were measured in postmortem serum from femoral blood in a series of sepsis-related fatalities and control cases. The aims were twofold: first, to determine whether Gas6 can be reliably determined in postmortem serum; and second, to assess its diagnostic potential in identifying sepsis-related deaths. Two study groups were prospectively formed, a sepsis-related fatalities group (24 cases) and a control group (24 cases) including cases of deep vein thrombosis and fatal pulmonary embolism, cases of systemic inflammatory response syndrome in severe trauma, cases of end-stage renal failure, and cases of hanging (non-septic, non-SIRS, non-end stage renal failure cases). The preliminary results of this study seem to indicate that Gas6 can be effectively measured in postmortem serum. However, Gas6 levels in sepsis-related fatalities do not appear to be clearly distinguishable from concentrations in pulmonary embolism, severe trauma, and end-stage renal failure cases. These findings tend to support previous reports that indicated that Gas6 behaves as an acute phase reactant and can be considered a general marker of inflammation rather than a specific biomarker of sepsis.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Palmiere C,Augsburger Mdoi
10.1007/s00414-015-1230-2subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1079-84issue
5eissn
0937-9827issn
1437-1596journal_volume
129pub_type
杂志文章abstract：:This paper describes the general design and main results of the Italian proficiency testing program for the analysis of psychoactive substances in urine, a long-term initiative created in 1995 on an educational basis and characterized by an innovative internet-based service for data exchange between laboratories and t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050279
更新日期：1999-01-01 00:00:00
abstract：:The assistance provided by specialised healthcare personnel to victims of a sexual violence cannot focus just on the clinical intervention appropriate for the lesions suffered by the patient, but must also take legal and forensic needs into account. Anamnestic data represents a crucial step towards the finding of fore...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1602-x
更新日期：2017-09-01 00:00:00
abstract：:Blank cartridge guns are generally regarded as being harmless and are not considered to be firearms in most countries. A comparison of the legal situations in Germany and Austria concerning weapons is given. There have been several reports of serious injuries and even fatalities due to these weapons. Ballistic experim...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050156
更新日期：1998-01-01 00:00:00
abstract：:Determinations of chronologic age are of great importance in forensic science. At present the aspartic acid racemization method on teeth provides one of the best means in adult individuals. However, if teeth are not available, some other stable tissue has to be used. In this study, the applicability of cartilage from ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01845611
更新日期：1995-01-01 00:00:00
abstract：:Bullet velocity is a basic parameter in wound ballistics studies. It is usually measured electronically by means of a variety of solid or photoelectric barriers connected to equipment measuring the time elapsing between impulses, enabling the velocity to be calculated. With the advent of Doppler radar velocity measure...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01247266
更新日期：1994-01-01 00:00:00
abstract：:Population studies on six short tandem repeat loci, HUMF13A01, HUMFXIIIB, HUMLIPOL, HUMTH01, HUMTPOX and HUMVWFA31 were carried out in a sample of unrelated Japanese individuals (n = 337-545) living in Gifu Prefecture (central region of Japan). Five alleles could be identified for HUMFXIIIB, six for HUMF13A01, HUMLIPO...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01369599
更新日期：1996-01-01 00:00:00
abstract：:Backspatter is the ejection of biological material from a gunshot entrance wound against the line of fire. This phenomenon was investigated experimentally in transverse gunshots to the heads of calves (n = 9) using two types of 9 mm Parabellum ammunition from shooting distances of 0-10 cm. The resulting bloodstains we...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01355519
更新日期：1996-01-01 00:00:00
abstract：:The yaw angle in flight of high velocity bullets has been discussed for a number of years, due to its contribution to the tumbling of the bullet in the target. Since few unclassified reports of contemporary bullets are available, we investigated the yaw angles of the bullets used in the M16A2, G3, AK-47 and AK-74 rifl...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01225601
更新日期：1994-01-01 00:00:00
abstract：:Genetic diversity indices and forensic parameters at 20 autosomal short tandem repeat (STR) loci were evaluated in 233 unrelated individuals of Himachal Pradesh, India. In total, 255 alleles were observed with an average of 11.25 ± 0.88 alleles per locus. None of the loci deviated from Hardy Weinberg Equilibrium. The ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-020-02254-8
更新日期：2020-09-01 00:00:00
abstract：:We hypothesized that miRNAs present in vitreous humor could be a sort of "biological black box," storing information about physiological and environmental circumstances at death. As a proof of concept, we analyzed the vitreous humor miRNA signature to explore its forensic potential applications, such as determining th...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0811-6
更新日期：2013-05-01 00:00:00
abstract：:In cooperation with the Crime Investigation Agency (Landeskriminalamt) of North Rhine-Westphalia, we carried out a study of 150 cases of (suspected) neonaticide dating from 1993 to 2007 from all over Germany. The autopsy reports and additional expert opinions (if performed) were evaluated for a minimum of 78 variables...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0841-8
更新日期：2013-05-01 00:00:00
abstract：:STR-based individualisation of biological deposits on bullets after perforation of tissue, can identify the person injured or killed by a particular bullet and comparison with the firearms used can identify the weapon and thus possibly the person who did the shooting. In this study, the effect of subsequent impacts on...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140000203
更新日期：2001-01-01 00:00:00
abstract：:For the interpretation of the concentration of morphine in blood samples of heroin consumers information about the concentration of the analgesic active morphine metabolite morphine-6-glucuronide is very important. Thus a simple but specific clean-up procedure based on immuno-affinity chromatography is presented for t...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050073
更新日期：1997-01-01 00:00:00
abstract：:Ancestry informative markers (AIMs) can be used to detect and adjust for population stratification and predict the ancestry of the source of an evidence sample. Autosomal single nucleotide polymorphisms (SNPs) are the best candidates for AIMs. It is essential to identify the most informative AIM SNPs across relevant p...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-015-1297-9
更新日期：2016-03-01 00:00:00
abstract：BACKGROUNDS:Aortic rupture or dissection as immediate cause of sudden death is encountered in forensic and clinical autopsy practice. Despite a common denominator of 'sudden aortic death' (SAD), we expect that in both settings the diagnostic workup, being either primarily legal or primarily disease related, differs sub...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-017-1560-3
更新日期：2017-11-01 00:00:00
abstract：:The accuracy of most age determination methods in adults is unsatisfactory and therefore more precise methods are required. Teeth provide several useful points about an individuals age. With advancing age secondary dentine is deposited along the wall of the dental pulp chamber leading to a reduction in the size of the...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0492-x
更新日期：2005-01-01 00:00:00
abstract：:A study was performed on the detection, separation and quantification of isomers from the new designer drugs named fluoroamphetamines (FAs) in forensic cases in eastern Denmark. The drugs were detected in whole blood extracts by ultraperformance liquid chromatography with time of flight mass spectrometer (UPLC-TOF-MS)...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-012-0671-0
更新日期：2012-07-01 00:00:00
abstract：:To study the population data of Y-chromosome STRs (Y-STRs) of Han population resided in Hunan province, we analyzed haplotypes of 26 Y-STRs (DYS19, DYS385a/b, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS481, DYS533, DYS549, DYS570, DYS576, DYS635, DYS643, DYS38...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/s00414-016-1411-7
更新日期：2017-01-01 00:00:00
abstract：:This paper deals with the usefulness of dental identification in the case of 28 human burn victims of a bus accident in Spain. Postmortem forensic procedures for identification were used including general external examination, routine photographs and radiographs and complementary biological methods. Dental identificat...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004149900099
更新日期：2000-01-01 00:00:00
abstract：:Determination of electrolyte concentrations (mainly potassium) in vitreous humour has long been considered an important tool in human death investigations for the estimation of the post-mortem interval (PMI). On the basis of its well known potential in ion analysis, capillary zone electrophoresis (CZE) has recently be...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140100239
更新日期：2002-02-01 00:00:00
abstract：:Allele frequencies for four short tandem repeat loci were determined in a population sample from Catalonia (NE Spain). After denaturing PAGE electrophoresis, 8 alleles were identified for D3S1358 (n=201), 10 alleles for D8S1179 (n=198), 13 alleles for D18S51 (n=197) and 11 alleles for D19S253 (n=201). No deviation fro...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s004140050205
更新日期：1998-01-01 00:00:00
abstract：:We have sequenced the entire mtDNA genome (mtGenome) of 241 individuals who match 1 of 18 common European Caucasian HV1/HV2 types, to identify sites that permit additional forensic discrimination. We found that over the entire mtGenome even individuals with the same HV1/HV2 type rarely match. Restricting attention to ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-004-0427-6
更新日期：2004-06-01 00:00:00
abstract：:Finding spermatozoa is of the utmost importance in judicial cases involving both the living and the dead; however, most of literature actually deals with inner genitalia and does not take into consideration the chance of external deposition of semen on skin, which is not rare. In addition, the most advanced microscopi...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-013-0817-8
更新日期：2013-09-01 00:00:00
abstract：:We investigated the polymorphism of five X-chromosomal short tandem repeat markers (ChrX STRs) loci (DXS7132, DXS981, DXS6803, DXS6809, and DXS6789) and their value for forensic applications. A fluorescent multiplex polymerase chain reaction (PCR) for amplifying five ChrX STRs loci in the same PCR reaction was set up....
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0223-9
更新日期：2008-05-01 00:00:00
abstract：:A cross-sectional study was carried out to assess chronological age estimation based on the stages of third lower molar development, following the eight stages (A-H) method of Demirjian et al. The final sample consisted of 1,054 orthopantomograms from Spanish individuals of known chronological age (range 14-21 years) ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-005-0530-3
更新日期：2005-11-01 00:00:00
abstract：:When preparing forensic age estimates for living subjects over 18 years of age, it is crucial to evaluate the stage of ossification of the medial clavicular epiphysis. The establishment of radiation-free imaging techniques for assessment of clavicular ossification would be desirable in order to reduce the radiation ex...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-007-0220-4
更新日期：2008-03-01 00:00:00
abstract：:Shooting incidents are often portrayed as resulting in a sometimes violent backwards displacement of the victim. This opinion is also not infrequently held by expert witnesses. The physical force responsible for this would be momentum (mass x velocity). The physics of momentum in ballistic injury is explained in detai...
journal_title：International journal of legal medicine
pub_type： 杂志文章,评审
doi：10.1007/BF01369676
更新日期：1996-01-01 00:00:00
abstract：:The tetrameric STRs, HUMTH01, HUMVWA31A and HUMFES/FPS, were studied in a population from the Basque Country (northern Spain) for their frequency distribution and applicability to identity and paternity testing. All systems conformed to Hardy-Weinberg equilibrium; pairwise comparisons demonstrated the allelic independ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/BF01245481
更新日期：1995-01-01 00:00:00
abstract：:Establishing individuality is an imperative aspect in any investigation procedure. At times, it becomes necessary to determine the sex of the individual to establish identity, and saliva stains found at the scene of crime are of major help in such cases. In the present study, we have determined the sex of the individu...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-008-0285-8
更新日期：2009-09-01 00:00:00
abstract：:The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known ...
journal_title：International journal of legal medicine
pub_type： 杂志文章
doi：10.1007/s00414-009-0404-1
更新日期：2011-01-01 00:00:00
