Abstract:
:Ancestry informative markers (AIMs) can be used to detect and adjust for population stratification and predict the ancestry of the source of an evidence sample. Autosomal single nucleotide polymorphisms (SNPs) are the best candidates for AIMs. It is essential to identify the most informative AIM SNPs across relevant populations. Several informativeness measures for ancestry estimation have been used for AIMs selection: absolute allele frequency differences (δ), F statistics (F ST), and informativeness for assignment measure (In). However, their efficacy has not been compared objectively, particularly for determining affiliations of major US populations. In this study, these three measures were directly compared for AIMs selection among four major US populations, i.e., African American, Caucasian, East Asian, and Hispanic American. The results showed that the F ST panel performed slightly better for population resolution based on principal component analysis (PCA) clustering than did the δ panel and both performed better than the In panel. Therefore, the 23 AIMs selected by the F ST measure were used to characterize the four major American populations. Genotype data of nine sample populations were used to evaluate the efficiency of the 23-AIMs panel. The results indicated that individuals could be correctly assigned to the major population categories. Our AIMs panel could contribute to the candidate pool of AIMs for potential forensic identification purposes.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Zeng X,Chakraborty R,King JL,LaRue B,Moura-Neto RS,Budowle Bdoi
10.1007/s00414-015-1297-9subject
Has Abstractpub_date
2016-03-01 00:00:00pages
341-52issue
2eissn
0937-9827issn
1437-1596pii
10.1007/s00414-015-1297-9journal_volume
130pub_type
杂志文章abstract::Establishing individuality is an imperative aspect in any investigation procedure. At times, it becomes necessary to determine the sex of the individual to establish identity, and saliva stains found at the scene of crime are of major help in such cases. In the present study, we have determined the sex of the individu...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-008-0285-8
更新日期:2009-09-01 00:00:00
abstract::The original version of this article contained an author name error. In this article, Katrina Madella has been corrected to Katrina Maddela. ...
journal_title:International journal of legal medicine
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00414-019-02031-2
更新日期:2019-05-01 00:00:00
abstract::Forensic age estimation of living individuals has become increasingly important in forensic practice with the constant increase of migration movements to developed countries. The method of Greulich and Pyle is one of the most frequently used methods for age determination. The aim of our study was to verify the reliabi...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-014-1028-7
更新日期:2015-01-01 00:00:00
abstract::In this study, the effect of sample purification on total signal intensities of samples amplified with genRES MPX-2 (nine-locus multiplex) prior to capillary electrophoretic analysis has been investigated. Sample purification with the Qiaquick PCR purification kit led to an increase of the relative fluorescent signal ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-001-0277-4
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The measurement of mast cell tryptase is commonly used to support the diagnosis of anaphylaxis. In the post-mortem setting, the literature recommends sampling from peripheral blood sources (femoral blood) but does not specify the exact sampling technique. Sampling techniques vary between pathologists, and it...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1738-8
更新日期:2018-05-01 00:00:00
abstract::Allele frequencies at the short tandem repeat (STR) loci HumACTBP2 and HumVWA were determined in 118 unrelated individuals from Northern Italy (Milan area). For locus HumACTBP2 (SE33) a total of 39 alleles was observed. Furthermore, two interalleles (N18m+N19m) and one allele (> N35) were found which were not observed...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050090
更新日期:1997-01-01 00:00:00
abstract::The ability to estimate stature from various parts of the body is essential in medicolegal investigations, particularly in cases in which human remains have been dismembered or mutilated. Therefore, the aim of this study was to generate linear regression models for predicting stature on the basis of sternum length in ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-014-0975-3
更新日期:2014-09-01 00:00:00
abstract::In three separate shooting incidents involving multiple gunshots, two FMJ bullets and one bullet fragment found at the scene (one from each case) were investigated for the presence of biological material from the victim after perforation. The surface of the missiles, which did not show obvious tissue traces when exami...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050041
更新日期:1997-01-01 00:00:00
abstract::ABO blood grouping of human bloodstains was performed by a sandwich ELISA using a species-specific monoclonal antibody to the amino-terminal cytoplasmic domain of human red cell membrane band 3. In a blind trial, all A, B and O bloodstains (a 1 cm long thread) and AB bloodstains (a 1.5 cm long thread) were accurately ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01642795
更新日期:1993-01-01 00:00:00
abstract::In a knife attack the perpetrator can unintentionally injure his own hand, if the knife does not have an adequate handguard and the tip of the blade hits a solid, mostly bony structure while being violently thrust into the victim's body. The injuries occurring under these conditions are localized on the flexor side of...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-004-0491-y
更新日期:2004-12-01 00:00:00
abstract::DNA-based prediction for externally visible characteristics such as eye color is already a useful tool in forensic criminal investigations. The IrisPlex system, consisting of six single nucleotide polymorphisms (SNPs) and a prediction model, was developed based on individuals from several European populations. Other r...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-013-0953-1
更新日期:2014-05-01 00:00:00
abstract::In wounds that are inflicted at least 60 min before death, histamine levels can increase up to 100%. This functional effect might have a morphometric counterpart. Mast cells play a crucial role in acute inflammatory reactions and in the healing process of wounds. Therefore, the density of these cells was immunohistoch...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-002-0304-0
更新日期:2003-02-01 00:00:00
abstract::Bloodstained threads (1 cm in length) were tested to identify human origin by a direct ELISA-ABC method using biotinylated antibody against human HbA0. By this method human bloodstains were clearly distinguishable from bloodstains of other species including Japanese monkey. The minimum detection limit of bloodstains p...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01369714
更新日期:1991-01-01 00:00:00
abstract::Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1232-0
更新日期:2015-09-01 00:00:00
abstract::Myocardial infarctions go along with biomechanical stress, i.e. stretching of muscle fibres, and the expression of certain marker molecules. We tested if two of those markers, endothelin-1 (ET-1) and growth differentiation factor 15 (GDF-15), can be used as immunohistochemical markers for myocardial ischaemia/infarcti...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1726-z
更新日期:2018-03-01 00:00:00
abstract::Genetic data from 21 autosomal insertion-null (INNULs) markers found in the InnoTyper® 21 Human DNA Analysis (InnoGenomics®) was evaluated in 190 unrelated individuals from Andalusia. Allele frequencies and forensic parameters were estimated for the 20 INNULs. All loci were in Hardy-Weinberg equilibrium in the study p...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02044-x
更新日期:2019-09-01 00:00:00
abstract::A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin K deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01369825
更新日期:1996-01-01 00:00:00
abstract::Allele frequencies and forensic parameters for 17 autosomal short tandem repeat (STR) loci were investigated from 1542 individuals of Va ethnic minority in Yunnan Province in the southwest of China. Also, genetic distances between Va and 13 published populations were compared, and a neighbor-joining (NJ) phylogenetic ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1620-8
更新日期:2017-09-01 00:00:00
abstract::Haemorrhages at the periostal-clavicular origin of the sternocleidomastoid muscles were found in 52 out of 54 cases of death by hanging. This cervical haemorrhage is most frequently found in death by hanging, but only seldomly seen in other causes of death and can therefore be regarded as being typical for death by ha...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01844825
更新日期:1995-01-01 00:00:00
abstract::It is difficult to carry out toxicological investigations in biological samples collected from extensively decomposed bodies and to interpret obtained results as several pitfalls should be considered: redistribution phenomena, degradation of xenobiotics during the postmortem period, contamination by putrefaction fluid...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-020-02267-3
更新日期:2020-07-01 00:00:00
abstract::The first aim of this study was to assess the diagnostic performance of presepsin (sCD14-ST) in postmortem serum from femoral blood compared to procalcitonin (PCT) to detect sepsis-related fatalities. The second aim was to compare sCD14-ST levels found in postmortem serum to the values in pericardial fluid to investig...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-012-0804-5
更新日期:2013-07-01 00:00:00
abstract::Single nucleotide polymorphism (SNP) typing offers promise to forensic genetics. Various strategies and panels for analyzing SNP markers for individual identification have been published. However, the best panels with fewer identity SNPs for all major population groups are still under discussion. This study aimed to f...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-015-1250-y
更新日期:2016-01-01 00:00:00
abstract::Allele frequencies of the Short tandem repeat systems HumVWA and HumACTBP2 were determined from 105 unrelated individuals from the area of Szeged, Hungary. A total of 8 alleles was detected for VWA, and 23 alleles were found for ACTBP2. In both systems no deviations from Hardy-Weinberg equilibrium were observed. A com...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF02432127
更新日期:1996-01-01 00:00:00
abstract::According to European regulations and the legislations of individual member states, children who seek asylum have a different set of rights than adults in a similar position. To protect these rights and ensure rule of law, migration authorities are commonly required to assess the age of asylum seekers who lack reliabl...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-017-1730-3
更新日期:2018-05-01 00:00:00
abstract::In forensic science, the unequivocal identification of the cellular origin of crime scene samples used for DNA profiling can provide crucial information for crime scene reconstruction. We have previously shown that various mRNA markers from genes with expression patterns specific for blood and saliva can be establishe...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-008-0249-z
更新日期:2009-01-01 00:00:00
abstract::Alleles of the STR systems HumFES/FPS, HumVWA and HumD21S11 were sequenced and analyzed. Sequence data revealed 3 different systems concerning the complexity of their sequence structure. HumFES/FPS belongs to the STR polymorphism with a simple repeat structure. Only 2 subtypes were found with a base substitution in th...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/BF01224779
更新日期:1994-01-01 00:00:00
abstract::The formation of skull fractures is an important topic in legal medicine. In particular, the influence of boundary conditions is controversially discussed in the literature. A study focusing solely on this aspect was missing. This study aimed to investigate the influence of boundary conditions on the energy threshold ...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02023-2
更新日期:2020-03-01 00:00:00
abstract::It is commonly accepted that crime scene recovery and recording are key moments of any judicial inspection in which investigators must decide on the correct strategies to put into place. Complex outdoor scenarios, presenting partially or entirely skeletonised remains, can benefit more than others by the intervention o...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-020-02456-0
更新日期:2020-12-19 00:00:00
abstract::The recovery of DNA from teeth is usually associated with the destruction of the evidential tooth using, for instance a special grinding mill. In some cases, however, a minimal invasive method of DNA retrieval with a high recovery is required particularly when historical material has to be investigated. A tooth attrib...
journal_title:International journal of legal medicine
pub_type: 传,历史文章,杂志文章
doi:10.1007/s00414-002-0336-5
更新日期:2003-04-01 00:00:00
abstract::Rapid identification of human remains following mass casualty events is essential to bring closure to family members and friends of the victims. Unfortunately, disaster victim identification, missing persons identification, and forensic casework analysis are often complicated by sample degradation due to exposure to h...
journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02186-y
更新日期:2020-05-01 00:00:00