Autonomic characteristics of nonclinical panic and blood phobia.

abstract：:In a neuroendocrine challenge paradigm, the present study investigated responses of schizophrenic patients to m-chlorophenylpiperazine (MCPP), a serotonin (5-hydroxytryptamine, 5HT) agonist. In an oral dose of 0.25 mg/kg, MCPP was administered in a placebo-controlled double-blind design to male schizophrenic patients ...

journal_title：Biological psychiatry

authors： Iqbal N,Asnis GM,Wetzler S,Kahn RS,Kay SR,van Praag HM

更新日期：1991-10-15 00:00:00

abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...

journal_title：Biological psychiatry

authors： Davies W,Humby T,Kong W,Otter T,Burgoyne PS,Wilkinson LS

更新日期：2009-08-15 00:00:00

abstract：BACKGROUND:The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has been proposed as a potential tool for identifying endophenotypes relevant to mood disorders. Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to...

journal_title：Biological psychiatry

authors： Carpenter LL,Tyrka AR,Ross NS,Khoury L,Anderson GM,Price LH

更新日期：2009-07-01 00:00:00

abstract：:Seven women with histories of puerperal psychosis and four with histories of puerperal major depression were consecutively treated with high-dose oral estrogen immediately following delivery. None of the women had histories of nonpuerperal affective disorder, and all women were affectively well throughout the current ...

journal_title：Biological psychiatry

authors： Sichel DA,Cohen LS,Robertson LM,Ruttenberg A,Rosenbaum JF

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Many first-degree relatives of patients with schizophrenia show deficits in clinical, neuropsychological, neurobiological and social domains, in the absence of psychosis. We recently reformulated Meehl's concept of schizotaxia to conceptualize the liability to schizophrenia, and we proposed preliminary crite...

journal_title：Biological psychiatry

authors： Stone WS,Faraone SV,Seidman LJ,Green AI,Wojcik JD,Tsuang MT

更新日期：2001-09-15 00:00:00

abstract：BACKGROUND:Most depressed adults exhibit dysregulation of the hypothalamic-pituitary-adrenal axis, including cortisol hyperreactivity to psychosocial challenge. In contrast, remarkably little is known about hypothalamic-pituitary-adrenal axis activity in response to psychosocial challenge among at-risk children and ado...

journal_title：Biological psychiatry

authors： Hankin BL,Badanes LS,Abela JR,Watamura SE

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability duri...

journal_title：Biological psychiatry

authors： Mellman TA,Knorr BR,Pigeon WR,Leiter JC,Akay M

更新日期：2004-05-01 00:00:00

abstract：:It has been generally accepted that increased thyroid function facilitates treatment response in depression. Recent data show that response to several antidepressant treatments, particularly lithium and carbamazepine, are associated with decreased thyroid hormone levels. An alternative hypothesis that decreased thyroi...

journal_title：Biological psychiatry

authors： Joffe RT,Roy-Byrne PP,Udhe TW,Post RM

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...

journal_title：Biological psychiatry

authors： Orozco S,Ehlers CL

更新日期：1998-08-15 00:00:00

abstract：:Cocaine can cause a variety of neuropsychiatric and neurobehavioral complications; however, it is uncertain whether cocaine causes persistent cerebral structural and neurochemical abnormalities in asymptomatic users. We studied 52 African-American men (26 human immunodeficiency virus-negative asymptomatic heavy cocain...

journal_title：Biological psychiatry

authors： Chang L,Mehringer CM,Ernst T,Melchor R,Myers H,Forney D,Satz P

更新日期：1997-12-15 00:00:00

abstract：:Previous studies indicate differences between schizophrenics and normals in thickness and overall size of the corpus callosum, particularly in female subjects. The present study compares the area of the corpus callosum as measured by magnetic resonance imaging (MRI) in men and women experiencing first-episode cases of...

journal_title：Biological psychiatry

authors： Hoff AL,Neal C,Kushner M,DeLisi LE

更新日期：1994-06-15 00:00:00

abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study ...

journal_title：Biological psychiatry

authors： Philip NS,Barredo J,van 't Wout-Frank M,Tyrka AR,Price LH,Carpenter LL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia. METHODS:S100B a...

journal_title：Biological psychiatry

authors： Steiner J,Walter M,Wunderlich MT,Bernstein HG,Panteli B,Brauner M,Jacobs R,Gos T,Rothermundt M,Bogerts B

更新日期：2009-06-15 00:00:00

abstract：:The etiology of Alzheimer's dementia (AD) is unknown, but several neurotransmitters, e.g., acetylcholine, have been implicated. Recently, the group of calcium channel antagonists have been reviewed for their potential neuropsychiatric applications. These agents are capable of enhancing cholinergic tone, neurofilament/...

journal_title：Biological psychiatry

authors： Tollefson GD

更新日期：1990-05-15 00:00:00

abstract：BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...

journal_title：Biological psychiatry

authors： Tozzi A,de Iure A,Bagetta V,Tantucci M,Durante V,Quiroga-Varela A,Costa C,Di Filippo M,Ghiglieri V,Latagliata EC,Wegrzynowicz M,Decressac M,Giampà C,Dalley JW,Xia J,Gardoni F,Mellone M,El-Agnaf OM,Ardah MT,Puglisi-A

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to ex...

journal_title：Biological psychiatry

authors： Dedovic K,Engert V,Duchesne A,Lue SD,Andrews J,Efanov SI,Beaudry T,Pruessner JC

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:A central cognitive function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release...

journal_title：Biological psychiatry

authors： Backhaus J,Junghanns K,Born J,Hohaus K,Faasch F,Hohagen F

更新日期：2006-12-15 00:00:00

abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

journal_title：Biological psychiatry

authors： Rittmannsberger H,Leblhuber F

更新日期：1992-08-15 00:00:00

abstract：:This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three con...

journal_title：Biological psychiatry

authors： Carter CS,Barch DM,Buchanan RW,Bullmore E,Krystal JH,Cohen J,Geyer M,Green M,Nuechterlein KH,Robbins T,Silverstein S,Smith EE,Strauss M,Wykes T,Heinssen R

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) is a common and severe psychiatric illness that affects 1-3% of the population and presents a well-established co-morbidity with major depressive disorder (MDD). Twin and family studies have suggested a genetic component in the etiology of OCD, although the mode of inherit...

journal_title：Biological psychiatry

authors： Karayiorgou M,Sobin C,Blundell ML,Galke BL,Malinova L,Goldberg P,Ott J,Gogos JA

更新日期：1999-05-01 00:00:00

abstract：:Several studies have indicated that patients with panic attacks have a higher rate of suicide attempts as well as deaths from suicide. Additionally, several investigators have presented case reports of individuals manifesting suicidal and violent behaviors directly and temporally associated with panic attacks. We repo...

journal_title：Biological psychiatry

authors： Korn ML,Kotler M,Molcho A,Botsis AJ,Grosz D,Chen C,Plutchik R,Brown SL,van Praag HM

更新日期：1992-03-15 00:00:00

abstract：BACKGROUND:Excitatory synaptic transmission in the nucleus accumbens (NAc) regulates the reinstatement of drug seeking, an animal model of relapse in human drug addicts. However, the functional adaptations at NAc synapses that mediate reinstatement are not clearly understood. METHODS:We assessed the behavioral respons...

journal_title：Biological psychiatry

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS:We used...

journal_title：Biological psychiatry

authors： Bearden CE,Thompson PM,Dalwani M,Hayashi KM,Lee AD,Nicoletti M,Trakhtenbroit M,Glahn DC,Brambilla P,Sassi RB,Mallinger AG,Frank E,Kupfer DJ,Soares JC

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Recent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features of AD can be present several decades before disease onset, we investigated whether effects of polygenic risk are...

journal_title：Biological psychiatry

authors： Foley SF,Tansey KE,Caseras X,Lancaster T,Bracht T,Parker G,Hall J,Williams J,Linden DE

更新日期：2017-01-15 00:00:00

abstract：:This report describes a series of experiments, all of which demonstrate a strong contribution of the behavioral pattern manifested at the time of initial amphetamine injection to the topography and development of the stereotypy that develops with chronic amphetamine intoxication. These initial behavioral patterns refl...

journal_title：Biological psychiatry

authors： Ellinwood EH Jr,kilbey MM

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:To study the influences of drug type and gender on the neuroendocrine response to neuroleptic treatment, we compared the endocrine actions of two neuroleptics with different receptor affinity profiles--a substituted benzamide, amisulpride, a selective D2-like dopamine antagonist; and a thioxanthene, flupenth...

journal_title：Biological psychiatry

authors： Gründer G,Wetzel H,Schlösser R,Anghelescu I,Hillert A,Lange K,Hiemke C,Benkert O

更新日期：1999-01-01 00:00:00

abstract：:Unlike disorders of other fields of medicine (eg., diabetes, heart disease), schizophrenia has been only marginally impacted by the study of animal models. This gap reflects the incomplete understanding of the causes and mechanisms of schizophrenia and the resulting lack of defined targets for model development. Howev...

journal_title：Biological psychiatry

authors： Kilts CD

更新日期：2001-12-01 00:00:00

abstract：:Patients with chronic hypercortisolemia due to Cushing's syndrome (CS) exhibit cognitive dysfunction. Because glucocorticoid excess is associated with hippocampal damage in animals, and the hippocampus participates in learning and memory, we explored the relationships between hippocampal formation (HF) volume, memory ...

journal_title：Biological psychiatry

authors： Starkman MN,Gebarski SS,Berent S,Schteingart DE

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Consistent with the fetal programming hypothesis, effects of maternal prenatal anxiety have been found to predict various measures of infant temperament in the early postnatal period. In recent years, a polymorphism in the serotonin transporter gene (5-HTTLPR) emerged as a moderator of diverse environmental ...

journal_title：Biological psychiatry

authors： Pluess M,Velders FP,Belsky J,van IJzendoorn MH,Bakermans-Kranenburg MJ,Jaddoe VW,Hofman A,Arp PP,Verhulst FC,Tiemeier H

更新日期：2011-03-15 00:00:00

abstract：:Schizophrenia is a complex illness with multiple pathophysiologic factors that contribute to its psychopathology. One strategy to identify these factors is to observe them in isolation from each other, by characterizing their expression in the relatives of schizophrenic probands. By Mendel's second law, each genetic f...

journal_title：Biological psychiatry

authors： Waldo MC,Adler LE,Leonard S,Olincy A,Ross RG,Harris JG,Freedman R

更新日期：2000-02-01 00:00:00