Abstract：
:Previous studies indicate differences between schizophrenics and normals in thickness and overall size of the corpus callosum, particularly in female subjects. The present study compares the area of the corpus callosum as measured by magnetic resonance imaging (MRI) in men and women experiencing first-episode cases of schizophrenia. The corpus callosum area is also correlated with measures of neuropsychological function. The results of this study suggest that women who are first-episode schizophrenic patients have a smaller total corpus callosum area than female controls, with no difference noted for men. In normal controls, a larger corpus callosum was associated with better cognitive function, whereas in schizophrenics, no such relationship emerged.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Hoff AL,Neal C,Kushner M,DeLisi LEdoi
10.1016/0006-3223(94)91237-8subject
Has Abstractpub_date
1994-06-15 00:00:00pages
913-9issue
12eissn
0006-3223issn
1873-2402pii
0006-3223(94)91237-8journal_volume
35pub_type
杂志文章abstract：:Hyperactivity of the hypothalamic--pituitary--adrenal (HPA) axis has been reliably observed in patients with major depression. One of the primary features of this HPA axis hyperactivity is reduced sensitivity to the inhibitory effects of the glucocorticoid dexamethasone on the production of adrenocorticotropic hormone...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(00)01088-x
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice. In many behavioral assays, it can be difficult to determine if these adaptations reflect core signs of depression. We designed studies to characterize the effects of CSDS on sensitivity to reward because anhedonia (reduce...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.12.014
更新日期：2014-10-01 00:00:00
abstract：:The present study was undertaken in order to further explore the relationship between monoamine levels and hypothalamic-pituitary-adrenocortical (HYPAC) functioning and suicidal behavior in depressed patients. One hundred and thirty-two depressed inpatients participated in the NIMH Collaborative Study on the Psychobio...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(86)90241-6
更新日期：1986-07-01 00:00:00
abstract：:Several findings support the hypothesis that the striatum is implicated in executive functions and in the modulation of goal-directed behavior, and could play a key role in the pathophysiology and in the production of symptoms and signs in schizophrenia. We have studied the relationship between the objective measures ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00017-6
更新日期：1997-11-01 00:00:00
abstract：:Studies at the basic and clinical levels demonstrate that neuronal atrophy and cell death occur in response to stress and in the brains of depressed patients. Although the mechanisms have yet to be fully elucidated, progress has been made in characterizing the signal transduction cascades that control neuronal atrophy...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)00935-5
更新日期：2000-10-15 00:00:00
abstract：BACKGROUND:Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several transgenic mouse models of AD. Because the LC contains multipl...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.06.013
更新日期：2013-03-01 00:00:00
abstract：:The functional role of cholecystokinin in the central nervous system is unknown. The tetra peptide CCK-4 was previously observed to induce panic attacks in a majority of normal volunteers and patients with panic disorder. Furthermore, it had been demonstrated that pretreatment with 10-50 mg of L-365,260, a selective C...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0006-3223(94)00190-E
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to ex...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.07.025
更新日期：2010-11-01 00:00:00
abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90248-k
更新日期：1991-06-01 00:00:00
abstract：:Previous studies have suggested that tardive dyskinesia may occur more frequently in patients who smoke. Further evidence of an interaction between smoking and movement disorders includes the low lifetime exposure to cigarettes found in Parkinson's disease patients. In this study 126 patients with chronic psychiatric ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90163-g
更新日期：1991-07-15 00:00:00
abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.10.017
更新日期：2012-02-15 00:00:00
abstract：BACKGROUND:Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2018.09.027
更新日期：2019-03-01 00:00:00
abstract：:A high incidence of behavioral and learning difficulties has been found in juvenile seizure-prone baboons presented with a graded series of operant behavioral task challenges. The animals fell into two distinct groups based upon the rate at which their operant performance was able to develop, the amount of day-to-day ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：BACKGROUND:Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS:Fourteen outpatients from the psychiatric department diagnosed with depres...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01273-2
更新日期：2002-03-15 00:00:00
abstract：BACKGROUND:Fear learning in stressful situations is highly adaptive for survival by steering behavior in subsequent situations, but fear learning can become disproportionate in vulnerable individuals. Despite the potential clinical significance, the mechanism by which stress modulates fear learning is poorly understood...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2015.02.014
更新日期：2015-12-15 00:00:00
abstract：BACKGROUND:In view of the effects of stress on synaptic plasticity, the regulation of synaptophysin and synaptotagmin expression by immobilization was analyzed by in situ hybridization. METHODS:Rats were exposed to immobilization stress, which induced typical behavioral alterations, such as reduced locomotor activity ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01229-x
更新日期：2001-11-15 00:00:00
abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.06.006
更新日期：2020-01-15 00:00:00
abstract：BACKGROUND:Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknow...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.10.038
更新日期：2005-02-01 00:00:00
abstract：:Research published in the past decade that used quantitative indices to evaluate the waking EEG characteristics of depressed patients is reviewed. Methodological problems that make results of different research laboratories difficult to compare include diagnostic heterogeneity of depressed groups, lack of inclusion of...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(90)90591-o
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:The anterior cingulate and medial prefrontal cortex play an important role in the inhibition of responses, as measured by the Stroop task, as well as in emotional regulation. Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpos...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.10.001
更新日期：2004-03-15 00:00:00
abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90040-7
更新日期：1992-08-15 00:00:00
abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90061-4
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Inositol has been reported to be an effective treatment in depression, and we hypothesized that inositol addition might enhance or speed up response to serotonin selective reuptake inhibitors (SSRI). METHODS:Twenty-seven depressed patients completed a double-blind controlled 4-week trial of SSRI plus placeb...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-3223(98)00145-0
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated. METHODS:The first consecutive 1000 adult bipolar patients enrolled in the National Institute of Mental Hea...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.01.022
更新日期：2004-05-01 00:00:00
abstract：:The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepre...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(99)00158-4
更新日期：1999-11-01 00:00:00
abstract：:N,N-Dimethyltryptamine (DMT) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (Fisher 344/Mai) who were trained to a high, stable base line of conditioned avoidance responding in the shuttlebox. DMT produced dose-dependent disruptive effects, as a sig...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1977-06-01 00:00:00
abstract：BACKGROUND:Since low serum iron has been reported in a variety of neuropsychiatric motor disorders, this study was conducted to examine serum iron in patients with a catatonic disorder. METHODS:Forty catatonic and 40 noncatatonic psychotic patients were studied in relation to serum iron levels. The association of seru...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00137-1
更新日期：1999-03-15 00:00:00
abstract：BACKGROUND:Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD). METHODS:In a placebo-controlled study, we examined 11 subjects with PTSD and 11 healthy...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2006.01.014
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:There is an increasing recognition that the pathophysiology of mental disorders could be the result of deregulation of synaptic plasticity with alterations of neurotrophins. The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has been extensiv...
journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2006.08.025
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety. METHODS:We used Fos expression for mapping of neuronal activation patterns in response to mild anxiety-provoking challenges. RESULTS:In both l...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.10.021
更新日期：2004-04-01 00:00:00
