Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.

abstract：:Several findings support the hypothesis that the striatum is implicated in executive functions and in the modulation of goal-directed behavior, and could play a key role in the pathophysiology and in the production of symptoms and signs in schizophrenia. We have studied the relationship between the objective measures ...

journal_title：Biological psychiatry

authors： Stratta P,Mancini F,Mattei P,Daneluzzo E,Casacchia M,Rossi A

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:The study assessed the efficacy and tolerability of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in the treatment of pathologic gambling (PG). METHODS:A 16-week randomized double-blind crossover design insured that each subject received 8 weeks of fluvoxamine and 8 weeks of a placebo. Fifte...

journal_title：Biological psychiatry

authors： Hollander E,DeCaria CM,Finkell JN,Begaz T,Wong CM,Cartwright C

更新日期：2000-05-01 00:00:00

abstract：:Our intent was to investigate systematically the overlap between conduct disorder (CD) and bipolar disorder (BPD). We hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the two disorders would have correlates of both. Results from a series of programmatic studie...

journal_title：Biological psychiatry

authors： Biederman J,Mick E,Wozniak J,Monuteaux MC,Galdo M,Faraone SV

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Nicotine is highly addictive when it is inhaled from tobacco smoke, whereas nicotine replacement products, which usually deliver nicotine orally or transdermally, rarely lead to addiction. It has been proposed that this is due in part to differences in the rate of nicotine delivery to the brain under the two...

journal_title：Biological psychiatry

authors： Samaha AN,Yau WY,Yang P,Robinson TE

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:To estimate the prevalence and correlates of clinician-diagnosed DSM-IV nonaffective psychosis (NAP) in a national household survey. METHODS:Data came from the United States National Comorbidity Survey Replication (NCS-R). A screen for NAP was followed by blinded sub-sample clinical reappraisal interviews. ...

journal_title：Biological psychiatry

authors： Kessler RC,Birnbaum H,Demler O,Falloon IR,Gagnon E,Guyer M,Howes MJ,Kendler KS,Shi L,Walters E,Wu EQ

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic re...

journal_title：Biological psychiatry

authors： Wong CG,Stevens MC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Both corticotropin-releasing factor (CRF) and glucocorticoid receptors (GR) are implicated in the psychotic symptoms of psychiatric disorders. Correspondingly, it is of interest to determine their respective involvement in the sensorimotor gating deficits displayed by transgenic mice overexpressing CRF. Thes...

journal_title：Biological psychiatry

authors： Groenink L,Dirks A,Verdouw PM,de Graaff M,Peeters BW,Millan MJ,Olivier B

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment. METHODS:In this multicenter, double-blind study, outpatients with recurrent unipolar major depression were randomly assigned to receive venlafaxine ER (75-3...

journal_title：Biological psychiatry

authors： Keller MB,Trivedi MH,Thase ME,Shelton RC,Kornstein SG,Nemeroff CB,Friedman ES,Gelenberg AJ,Kocsis JH,Dunner DL,Dunlop BW,Hirschfeld RM,Rothschild AJ,Ferguson JM,Schatzberg AF,Zajecka JM,Pedersen R,Yan B,Ahmed S,Schm

更新日期：2007-12-15 00:00:00

abstract：BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...

journal_title：Biological psychiatry

authors： Tolbert LM,Russell DS,Duman RS

更新日期：2003-11-15 00:00:00

abstract：BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correl...

journal_title：Biological psychiatry

authors： Siegle GJ,Granholm E,Ingram RE,Matt GE

更新日期：2001-04-01 00:00:00

abstract：:The acoustic startle response (ASR) and midlatency auditory evoked potentials (AEP) have been utilized in the measurement of sensory inhibition. Using these different paradigms, abnormalities suggesting a lack of normal inhibition have been noted in a number of psychiatric syndromes. To date, the most commonly used se...

journal_title：Biological psychiatry

authors： Schwarzkopf SB,Lamberti JS,Smith DA

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Knockout (KO) mice invalidated for the dopamine transporter (DAT) constitute a powerful animal model of neurobiological alterations associated with hyperdopaminergia relevant to schizophrenia and attention-deficit/hyperactivity disorder (ADHD). METHODS:Because of continuously increasing evidence for a neuro...

journal_title：Biological psychiatry

authors： Tzavara ET,Li DL,Moutsimilli L,Bisogno T,Di Marzo V,Phebus LA,Nomikos GG,Giros B

更新日期：2006-03-15 00:00:00

abstract：:The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...

journal_title：Biological psychiatry

authors： DeMet EM,Chicz-DeMet A,Fleischmann J

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Since the inception of the diagnosis posttraumatic stress disorder (PTSD), attempts have been undertaken to understand why only a subpopulation of individuals exposed to trauma develops PTSD. Cerebral gray matter reductions have been suggested to be a crucial pathobiological marker of PTSD. However, a quanti...

journal_title：Biological psychiatry

authors： Kühn S,Gallinat J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The high rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms and anatomical pathways. Limbic structures, such as the nucleus accumbens (NAc), play a crucial role in both disorders, yet how different cell types within these structures contribute to the pathogenesi...

journal_title：Biological psychiatry

authors： Arango-Lievano M,Schwarz JT,Vernov M,Wilkinson MB,Bradbury K,Feliz A,Marongiu R,Gelfand Y,Warner-Schmidt J,Nestler EJ,Greengard P,Russo SJ,Kaplitt MG

更新日期：2014-11-15 00:00:00

abstract：:The P300 response to an auditory two-tone discrimination task has previously been reported to have prolonged latency and reduced amplitude in schizophrenia and borderline personality disorder. In this study, P300 was recorded from 23 subjects with borderline personality disorder, 12 subjects fulfilling criteria for bo...

journal_title：Biological psychiatry

authors： Kutcher SP,Blackwood DH,Gaskell DF,Muir WJ,St Clair DM

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:DISC1 has been suggested as a causative gene for psychoses in a large Scottish kindred. PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study. METHODS:By TaqMan re...

journal_title：Biological psychiatry

authors： Anitha A,Nakamura K,Yamada K,Iwayama Y,Toyota T,Takei N,Iwata Y,Suzuki K,Sekine Y,Matsuzaki H,Kawai M,Miyoshi K,Katayama T,Matsuzaki S,Baba K,Honda A,Hattori T,Shimizu S,Kumamoto N,Tohyama M,Yoshikawa T,Mori N

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Despite cognitive function impairment in depression, its relationship to treatment outcome is not well understood. Here, we examined whether pretreatment activation of cortical circuitry during test of cognitive functions predicts outcomes for three commonly used antidepressants. METHODS:Eighty medication-f...

journal_title：Biological psychiatry

authors： Gyurak A,Patenaude B,Korgaonkar MS,Grieve SM,Williams LM,Etkin A

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:There is increasing evidence that antipsychotic (APD) may affect brain structure directly. To examine this, we developed a rodent model that uses clinically relevant doses and serial magnetic resonance imaging (MRI), followed by postmortem histopathological analysis to study the effects of APD on brain struc...

journal_title：Biological psychiatry

authors： Vernon AC,Natesan S,Modo M,Kapur S

更新日期：2011-05-15 00:00:00

abstract：BACKGROUND:As many as 30% of individuals diagnosed with depression are nonresponsive to traditional antidepressant medication. Augmentation and combination strategies have emerged in an attempt to address this issue. Atypical antipsychotics (e.g., olanzapine), when added to a selective serotonin reuptake inhibitor (e.g...

journal_title：Biological psychiatry

authors： Seager MA,Huff KD,Barth VN,Phebus LA,Rasmussen K

更新日期：2004-06-01 00:00:00

abstract：:Using computed tomography, lateral ventricular size was determined in 45 schizophrenic and 22 affective disorder patients, and was found in both patient groups to be greater than that of 62 similarly aged headache controls. While drug-free, the 15 schizophrenics with ventricles 1 standard deviation greater than the ag...

journal_title：Biological psychiatry

authors： Luchins DJ,Lewine RR,Meltzer HY

更新日期：1984-01-01 00:00:00

abstract：:Dynamic computed tomography (CT) scanning of the brain was performed in 26 patients with primary degenerative dementia (PDD) and in 15 age-matched controls without evidence of a dementing illness. Changes in CT density values over time were obtained for 16 regions of interest (ROIs) that were carefully chosen to avoid...

journal_title：Biological psychiatry

authors： Dysken MW,Nelson MJ,Hoover KM,Kuskowski M,McGeachie R

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:The cystine-glutamate exchanger is downregulated after chronic cocaine, resulting in reduced extracellular levels of nucleus accumbens glutamate. The importance of cocaine-induced loss of glutamate homeostasis is revealed by N-acetylcysteine restoring cystine-glutamate exchange and attenuating reinstatement ...

journal_title：Biological psychiatry

authors： Knackstedt LA,Melendez RI,Kalivas PW

更新日期：2010-01-01 00:00:00

abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

journal_title：Biological psychiatry

authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:A study was performed to analyze time-of-day variations of different indicators of attention and their interrelations. METHODS:After a sufficiently long all-night sleep 12 healthy non-sleep-deprived subjects ran through a test battery (Stanford Sleepiness Scale, Visual Analogue Scale, Critical Flicker Fusio...

journal_title：Biological psychiatry

authors： Kraemer S,Danker-Hopfe H,Dorn H,Schmidt A,Ehlert I,Herrmann WM

更新日期：2000-12-01 00:00:00

abstract：:The frequencies of HLA antigens were examined in a sample of 75 patients with schizophrenia and 35 patients with mood disorders. We compared the data obtained from this population with data obtained in another study with 3731 healthy subjects. Statistically significant increases were observed in the frequencies of HLA...

journal_title：Biological psychiatry

authors： Ozcan ME,Taskin R,Banoglu R,Babacan M,Tuncer E

更新日期：1996-05-15 00:00:00

abstract：:There is recognition that the cognitive symptoms of schizophrenia have the most substantial impact on illness outcome. Domains of cognition reported to be significantly affected include serial learning, executive function, vigilance, and distractibility, to name a few. Dopamine activity at D1 receptors mediates many c...

journal_title：Biological psychiatry

authors： Friedman JI,Temporini H,Davis KL

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS:Twenty elderly patients meeting DSM-IV criteria for m...

journal_title：Biological psychiatry

authors： Lai T,Payne ME,Byrum CE,Steffens DC,Krishnan KR

更新日期：2000-11-15 00:00:00

abstract：BACKGROUND:Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligod...

journal_title：Biological psychiatry

authors： Takahashi N,Nielsen KS,Aleksic B,Petersen S,Ikeda M,Kushima I,Vacaresse N,Ujike H,Iwata N,Dubreuil V,Mirza N,Sakurai T,Ozaki N,Buxbaum JD,Sap J

更新日期：2011-10-01 00:00:00

abstract：:Children who experience chronic stressors are vulnerable to emotional and physical health problems across the lifespan. This phenomenon raises questions for scientists and clinicians alike. How does adversity get under the skin of the developing child? Through what mechanisms does it confer vulnerability to a heteroge...

journal_title：Biological psychiatry

authors： Nusslock R,Miller GE

更新日期：2016-07-01 00:00:00