当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > The effects of stimulant medication on working memory functional connectivity in attention-deficit/hyperactivity disorder.

The effects of stimulant medication on working memory functional connectivity in attention-deficit/hyperactivity disorder.

Abstract：

BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic resonance imaging (fMRI) to examine medication-related changes in brain activation and functional connectivity in ADHD. METHODS:Eighteen ADHD-combined subtype youths (ages 11-17) twice completed a Sternberg working memory fMRI task in a randomized, double-blind, placebo-controlled design. Medications were individualized as patients' standard, clinically effective psychostimulant (e.g., methylphenidate or dextroamphetamine/amphetamine combination) dose. Brain activity and functional connectivity were characterized using group independent component analysis. SPM5 repeated-measures t tests compared ADHD patients' network engagement and regional functional connectivity on and off medication. RESULTS:Independent component analysis identified six frontoparietal networks/components with hemodynamic responses to encoding/maintenance or retrieval phases of the Sternberg fMRI task. On medication, three of these networks significantly increased activation. Functional connectivity analyses found medication led to recruitment of additional brain regions that were not engaged into the networks when participants were on placebo. Also, medication strengthened connectivity of some frontoparietal regions. Many connectivity changes were directly related to improved working memory reaction time. Overall, there was strong evidence for regional functional connectivity changes following medication in structures previously implicated as abnormal in ADHD, such as anterior cingulate, ventrolateral prefrontal cortex, and precuneus. CONCLUSIONS:Stimulant medication has widespread effects on the functional connectivity of frontoparietal brain networks, which might be a mechanism that underlies their beneficial effects on working memory performance.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Wong CG,Stevens MC

doi

10.1016/j.biopsych.2011.11.011

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

458-66

issue

5

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(11)01126-7

journal_volume

71

pub_type

杂志文章,随机对照试验

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Rapid delivery of nicotine promotes behavioral sensitization and alters its neurobiological impact.

    abstract：BACKGROUND:Nicotine is highly addictive when it is inhaled from tobacco smoke, whereas nicotine replacement products, which usually deliver nicotine orally or transdermally, rarely lead to addiction. It has been proposed that this is due in part to differences in the rate of nicotine delivery to the brain under the two...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.11.040

    authors： Samaha AN,Yau WY,Yang P,Robinson TE

    更新日期：2005-02-15 00:00:00

  • Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk.

    abstract：BACKGROUND:Bipolar disorder (BD) is characterized by a dysregulation of affect and impaired integration of emotion with cognition. These traits are also expressed in probands at high genetic risk of BD. The inferior frontal gyrus (IFG) is a key cortical hub in the circuits of emotion and cognitive control, and it has b...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2016.08.018

    authors： Roberts G,Lord A,Frankland A,Wright A,Lau P,Levy F,Lenroot RK,Mitchell PB,Breakspear M

    更新日期：2017-04-15 00:00:00

  • Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression.

    abstract：BACKGROUND:Cerebrospinal fluid (CSF) levels of soluble amyloid precursor protein (sAPP) and its alpha-secreted form (alpha-sAPP) were investigated as a means to distinguish between individuals with mild cognitive impairment (MCI) and Alzheimer-type dementia (DAT) and those with major depressive episode (MDE) showing se...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.09.007

    authors： Post A,Ackl N,Rücker M,Schreiber Y,Binder EB,Ising M,Sonntag A,Holsboer F,Almeida OF

    更新日期：2006-05-01 00:00:00

  • Erythrocyte acetylcholinesterase in psychiatric disorders and controls.

    abstract：:Acetylcholinesterase (AChE) from erythrocytes was solubilized by Triton X-100. Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. There were no interindividual differences ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90052-7

    authors： Fritze J,Beckmann H

    更新日期：1987-09-01 00:00:00

  • Negative symptoms in schizophrenia and nailfold plexus visibility.

    abstract：:Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the n...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90195-r

    authors： Poole JH,Maricq HR,Alson E,Willerman L

    更新日期：1991-04-15 00:00:00

  • General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.

    abstract：BACKGROUND:Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to ge...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.02.019

    authors： Fornito A,Yoon J,Zalesky A,Bullmore ET,Carter CS

    更新日期：2011-07-01 00:00:00

  • Abnormalities of brain structure and density in schizophrenia.

    abstract：:Quantitative and qualitative measures of brain morphology were derived through CT scans using computer-assisted methodology in patients with schizophrenia or schizo-affective psychosis and headache controls. Schizophrenics had significantly higher density of white matter, together with greater right vs. left asymmetry...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Largen JW Jr,Smith RC,Calderon M,Baumgartner R,Lu RB,Schoolar JC,Ravichandran GK

    更新日期：1984-07-01 00:00:00

  • Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior.

    abstract：BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2017.05.026

    authors： Wohleb ES,Terwilliger R,Duman CH,Duman RS

    更新日期：2018-01-01 00:00:00

  • Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.

    abstract：BACKGROUND:Binge eating is associated with obesity and has been conceptualized as "food addiction." However, this view has received only inconsistent support in humans, and limited evidence relates key neurocircuitry to the disorder. Moreover, relatively few studies have used pharmacologic functional magnetic resonance...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2012.10.022

    authors： Cambridge VC,Ziauddeen H,Nathan PJ,Subramaniam N,Dodds C,Chamberlain SR,Koch A,Maltby K,Skeggs AL,Napolitano A,Farooqi IS,Bullmore ET,Fletcher PC

    更新日期：2013-05-01 00:00:00

  • Prepartum and Postpartum Maternal Depressive Symptoms Are Related to Children's Brain Structure in Preschool.

    abstract：BACKGROUND:Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children. Prenatal depression is associated with altered brain gray matter in children, though relations between postpartum depression and children's brains and the role of white matter are unclear. ME...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.12.004

    authors： Lebel C,Walton M,Letourneau N,Giesbrecht GF,Kaplan BJ,Dewey D

    更新日期：2016-12-01 00:00:00

  • Understanding interpersonal function in psychiatric illness through multiplayer economic games.

    abstract：:Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2012.03.033

    authors： King-Casas B,Chiu PH

    更新日期：2012-07-15 00:00:00

  • Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa.

    abstract：BACKGROUND:In food-restricted rats, leptin suppresses semistarvation-induced hyperactivity (SIH) and decreases exploratory behavior. Leptin ameliorates anxiety-related movement in ob/ob mice. In this study, we assessed the relationship between leptin and qualities of physical activity and restlessness in acute anorexia...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.11.001

    authors： Holtkamp K,Herpertz-Dahlmann B,Hebebrand K,Mika C,Kratzsch J,Hebebrand J

    更新日期：2006-08-01 00:00:00

  • Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

    abstract：BACKGROUND:Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across several c...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.12.029

    authors： Shelton MA,Newman JT,Gu H,Sampson AR,Fish KN,MacDonald ML,Moyer CE,DiBitetto JV,Dorph-Petersen KA,Penzes P,Lewis DA,Sweet RA

    更新日期：2015-09-15 00:00:00

  • Double-blind comparison of olanzapine versus clozapine in schizophrenic patients clinically eligible for treatment with clozapine.

    abstract：BACKGROUND:The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge. Clozapine has been one treatment option; however, it is not universally effective and is limited in its use by safety concerns. With the introduction of newer agents, their performance re...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0006-3223(00)01026-x

    authors： Tollefson GD,Birkett MA,Kiesler GM,Wood AJ,Lilly Resistant Schizophrenia Study Group.

    更新日期：2001-01-01 00:00:00

  • Olfactory sensitivity in major depressive disorder and obsessive compulsive disorder.

    abstract：:Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of an...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(94)91142-8

    authors： Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

    更新日期：1994-05-15 00:00:00

  • Neuroimaging-based Individualized Prediction of Cognition and Behavior for Mental Disorders and Health: Methods and Promises.

    abstract：:The neuroimaging community has witnessed a paradigm shift in biomarker discovery from using traditional univariate brain mapping approaches to multivariate predictive models, allowing the field to move toward a translational neuroscience era. Regression-based multivariate models (hereafter "predictive modeling") provi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.02.016

    authors： Sui J,Jiang R,Bustillo J,Calhoun V

    更新日期：2020-12-01 00:00:00

  • Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors.

    abstract：:The total number of neurons was estimated in eight brains from chronic schizophrenic men and compared with 16 gender- and age-matched controls. The average total neocortical nerve cell number was 22.12.10(9) in schizophrenics and 22.06.10(9) in controls. The estimate of total cell numbers can not demonstrate more subt...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90065-l

    authors： Pakkenberg B

    更新日期：1993-12-01 00:00:00

  • Clinical implications of pervasive manic symptoms in children.

    abstract：BACKGROUND:Prior investigations of cross-informant agreement among parents, teachers, and clinicians about externalizing and internalizing problems have not directly addressed agreement about manic symptoms. METHODS:We identified three groups from a large cohort of youths, aged 8-12 years, treated on an inpatient unit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00068-4

    authors： Carlson GA,Youngstrom EA

    更新日期：2003-06-01 00:00:00

  • Saliva cortisol in posttraumatic stress disorder: a community epidemiologic study.

    abstract：BACKGROUND:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, so it was expected that posttraumatic stress disorder (PTSD) would be associated with activation of this axis; however, studies have found both increased and decreased cortisol in PTSD. To address this question, we collected saliva cortisol at h...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.05.011

    authors： Young EA,Breslau N

    更新日期：2004-08-01 00:00:00

  • Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients.

    abstract：:Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90236-7

    authors： Catalano M,Nobile M,Novelli E,Nöthen MM,Smeraldi E

    更新日期：1993-10-01 00:00:00

  • Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability.

    abstract：BACKGROUND:Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NAcsh) of adults follow...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.04.026

    authors： Tomasiewicz HC,Jacobs MM,Wilkinson MB,Wilson SP,Nestler EJ,Hurd YL

    更新日期：2012-11-15 00:00:00

  • Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

    abstract：BACKGROUND:Our previous studies indicated that N-methyl-D-aspartate receptor (NMDAR) deletion from a subset of corticolimbic interneurons in the mouse brain during early postnatal development is sufficient to trigger several behavioral and pathophysiological features resembling the symptoms of human schizophrenia. Inte...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.12.004

    authors： Jiang Z,Rompala GR,Zhang S,Cowell RM,Nakazawa K

    更新日期：2013-05-15 00:00:00

  • Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons.

    abstract：BACKGROUND:Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.05.006

    authors： Pistis M,Perra S,Pillolla G,Melis M,Muntoni AL,Gessa GL

    更新日期：2004-07-15 00:00:00

  • Thyroid function and affective illness: a reappraisal.

    abstract：:It has been generally accepted that increased thyroid function facilitates treatment response in depression. Recent data show that response to several antidepressant treatments, particularly lithium and carbamazepine, are associated with decreased thyroid hormone levels. An alternative hypothesis that decreased thyroi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Joffe RT,Roy-Byrne PP,Udhe TW,Post RM

    更新日期：1984-12-01 00:00:00

  • Impaired motor skill learning in schizophrenia: implications for corticostriatal dysfunction.

    abstract：:We assessed skill learning in young and older schizophrenic patients using the rotary pursuit task. Schizophrenic patients displayed impaired learning on this task compared with normal control subjects, but older patients were not more impaired than young ones. The patients' rotary pursuit learning was not correlated ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(95)00130-1

    authors： Schwartz BL,Rosse RB,Veazey C,Deutsch SI

    更新日期：1996-02-15 00:00:00

  • Guanfacine potentiates the activation of prefrontal cortex evoked by warning signals.

    abstract：BACKGROUND:Warning signals evoke an alert state of readiness that prepares for a rapid response by priming a thalamo-frontal-striatal network that includes the dorsolateral prefrontal cortex (DLPFC). Animal models indicate that noradrenergic input is essential for this stimulus-driven activation of DLPFC, but the preci...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.04.013

    authors： Clerkin SM,Schulz KP,Halperin JM,Newcorn JH,Ivanov I,Tang CY,Fan J

    更新日期：2009-08-15 00:00:00

  • Quantitative craniofacial anomalies in a racially mixed schizophrenia sample.

    abstract：BACKGROUND:The observation that some patients with schizophrenia display subtly anomalous craniofacial features dates back to the early 1900s and has recently been hypothesized to reflect disrupted prenatal development also involving the brain. Most studies to date have used observer ratings rather than physical measur...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.06.034

    authors： Donovan-Lepore AM,Jaeger J,Czobor P,Abdelmessih S,Berns SM

    更新日期：2006-02-15 00:00:00

  • Nucleus accumbens neurons track behavioral preferences and reward outcomes during risky decision making.

    abstract：BACKGROUND:To make appropriate decisions, organisms must evaluate the risks and benefits of action selection. The nucleus accumbens (NAc) has been shown to be critical for this processing and is necessary for appropriate risk-based decision-making behavior. However, it is not clear how NAc neurons encode this informati...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.09.010

    authors： Sugam JA,Saddoris MP,Carelli RM

    更新日期：2014-05-15 00:00:00

  • Gender differences in electrophysiological responses to facial stimuli.

    abstract：BACKGROUND:A facial discrimination task was adapted to be used in an event-related potential (ERP) paradigm in order to evaluate whether young women's brain responses to affective stimuli differed from those of young men. METHODS:The stimuli used to generate a late positive component of the ERP, designated the "P450,"...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(97)00487-3

    authors： Orozco S,Ehlers CL

    更新日期：1998-08-15 00:00:00

  • Changes in cortisol and dehydroepiandrosterone in women victims of physical and psychological intimate partner violence.

    abstract：BACKGROUND:Although intimate partner violence (IPV) has a great impact on women's health, few studies have assessed the consequences on physiologic responses. METHODS:Women abused by their intimate male partners either physically (n = 70) or psychologically (n = 46) were compared with nonabused control women (n = 46)....

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.06.001

    authors： Pico-Alfonso MA,Garcia-Linares MI,Celda-Navarro N,Herbert J,Martinez M

    更新日期：2004-08-15 00:00:00