Olfactory sensitivity in major depressive disorder and obsessive compulsive disorder.

Abstract:

:Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of antidepressant drug therapy. No difference in olfactory sensitivity, to either odorant, was found between OCD patients and controls at any time. In MDD patients, a significant increase in the sensitivity to isoamyl acetate was observed 6 weeks after initiation of treatment, compared to controls.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Gross-Isseroff R,Luca-Haimovici K,Sasson Y,Kindler S,Kotler M,Zohar J

doi

10.1016/0006-3223(94)91142-8

subject

Has Abstract

pub_date

1994-05-15 00:00:00

pages

798-802

issue

10

eissn

0006-3223

issn

1873-2402

pii

0006-3223(94)91142-8

journal_volume

35

pub_type

杂志文章
  • Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk.

    abstract:BACKGROUND:Bipolar disorder (BD) is characterized by a dysregulation of affect and impaired integration of emotion with cognition. These traits are also expressed in probands at high genetic risk of BD. The inferior frontal gyrus (IFG) is a key cortical hub in the circuits of emotion and cognitive control, and it has b...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2016.08.018

    authors: Roberts G,Lord A,Frankland A,Wright A,Lau P,Levy F,Lenroot RK,Mitchell PB,Breakspear M

    更新日期:2017-04-15 00:00:00

  • Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.

    abstract:BACKGROUND:Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD. This randomized, placebo-controlled study of the efficacy and safety of nefazodone in preventing recurrence...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(02)01971-6

    authors: Gelenberg AJ,Trivedi MH,Rush AJ,Thase ME,Howland R,Klein DN,Kornstein SG,Dunner DL,Markowitz JC,Hirschfeld RM,Keitner GI,Zajecka J,Kocsis JH,Russell JM,Miller I,Manber R,Arnow B,Rothbaum B,Munsaka M,Banks P,Borian

    更新日期:2003-10-15 00:00:00

  • A study of relationships of serum glucose, insulin, free fatty acids, and free and total tryptophan to mental illness.

    abstract::To explore possible disturbances of cerebral monoamines linked to glucose metabolism, 18 schizophrenics, 21 neurotics, and 21 controls were given a 5-hr glucose tolerance test, and the effect of the glucose load on total and free tryptophan, insulin, and free fatty acids in serum was studied in medication-free patient...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Yaryura-Tobias JA,Chang A,Neziroglu F

    更新日期:1978-04-01 00:00:00

  • Perfusion abnormalities and decision making in cocaine dependence.

    abstract:BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Sev...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.biopsych.2004.06.031

    authors: Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TR

    更新日期:2004-10-01 00:00:00

  • REM sleep latency and contingent negative variation in endogenous depression. Suggestion for a common cholinergic mechanism.

    abstract::In a sample of 13 endogenous depressive inpatients, REM (rapid eye movement) latency (recorded over 4 consecutive nights after 2 habituation nights) and contingent negative variation amplitude showed significant relationship, suggesting that both parameters may depend on the same mechanisms, possibly cholinergic. ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(85)90115-5

    authors: Ansseau M,Machowski R,Franck G,Timsit-Berthier M

    更新日期:1985-12-01 00:00:00

  • Glutamate-based antidepressants: preclinical psychopharmacology.

    abstract::Over the past 20 years, converging lines of evidence have both linked glutamatergic dysfunction to the pathophysiology of depression and demonstrated that the glutamatergic synapse presents multiple targets for developing novel antidepressants. The robust antidepressant effects of the N-methyl-D-aspartate receptor ant...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2013.01.021

    authors: Pilc A,Wierońska JM,Skolnick P

    更新日期:2013-06-15 00:00:00

  • The effects of antidepressants on the thyroid axis in depression.

    abstract::Thirty-nine patients with major depression were studied to determine the differential effects of desipramine (DMI) and fluoxetine (FLU) on thyroid hormones. Twenty-six percent showed some abnormality in baseline thyroid hormone levels. There were no demonstrable differences for any of the thyroid indices from baseline...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(93)90311-z

    authors: Shelton RC,Winn S,Ekhatore N,Loosen PT

    更新日期:1993-01-15 00:00:00

  • Neural changes associated with treatment outcome in children with externalizing problems.

    abstract:BACKGROUND:The current study directly investigated whether changes in the neural correlates of self-regulation (SR) are associated with the effectiveness of treatment for the externalizing problems of children. METHODS:Seventy-one children 8-12 years of age with clinical levels of externalizing behavior and their fami...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2011.05.029

    authors: Woltering S,Granic I,Lamm C,Lewis MD

    更新日期:2011-11-01 00:00:00

  • Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia.

    abstract:BACKGROUND:Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predispositi...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2019.01.023

    authors: Wang SH,Hsiao PC,Yeh LL,Liu CM,Liu CC,Hwang TJ,Hsieh MH,Chien YL,Lin YT,Huang YT,Chen CY,Chandler SD,Faraone SV,Neale B,Glatt SJ,Tsuang MT,Hwu HG,Chen WJ

    更新日期:2019-07-01 00:00:00

  • Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients.

    abstract:BACKGROUND:Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available. METHODS:P50 and N100 suppression were assessed with an auditory double-click paradigm in five groups: 18 at-risk...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2008.02.006

    authors: Brockhaus-Dumke A,Schultze-Lutter F,Mueller R,Tendolkar I,Bechdolf A,Pukrop R,Klosterkoetter J,Ruhrmann S

    更新日期:2008-09-01 00:00:00

  • Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD.

    abstract::Prominent heightened arousal symptoms and clinical/laboratory findings implicate the central noradrenergic system in posttraumatic stress disorder (PTSD). Heightened arousal frequently manifests in relation to sleep in PTSD. Central noradrenergic systems have a role in regulating arousal levels during sleep. We theref...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(94)00238-X

    authors: Mellman TA,Kumar A,Kulick-Bell R,Kumar M,Nolan B

    更新日期:1995-08-01 00:00:00

  • Proton magnetic resonance spectroscopy of human basal ganglia: response to cocaine administration.

    abstract:BACKGROUND:Proton magnetic resonance spectroscopy was used to determine the effects of intravenous cocaine or placebo administration on human basal ganglia water and metabolite resonances. METHODS:Long echo time, proton magnetic resonance spectra of water and intracellular metabolites were continuously acquired from a...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(00)00897-0

    authors: Christensen JD,Kaufman MJ,Frederick B,Rose SL,Moore CM,Lukas SE,Mendelson JH,Cohen BM,Renshaw PF

    更新日期:2000-10-01 00:00:00

  • Effects of chronic lithium treatment on protein kinase C and cyclic AMP-dependent protein phosphorylation.

    abstract::Lithium inhibits the agonist-induced hydrolysis of phosphoinositides and the synthesis of cyclic AMP (cAMP) in rat brain preparations, each of which is linked to activation of specific protein kinases. Therefore, we examined the effects of chronic lithium treatment on protein kinase activities in rat hippocampus. Chro...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(91)91285-y

    authors: Casebolt TL,Jope RS

    更新日期:1991-02-01 00:00:00

  • Urinary tryptamine excretion in chronic schizophrenics with low platelet MAO activity.

    abstract::Reduced platelet MAO activity has been previously reported as a biochemical marker for a subgroup of psychiatric patients, including some chronic schizophrenics. As tryptamine metabolism appears to be sensitive to alterations in MAO activity, urinary tryptamine excretion was measured in chronic schizophrenics with low...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:

    authors: Sullivan JL,Coffey CE,Basuk B,Cavenar JO,Maltbie AA,Zung WW

    更新日期:1980-02-01 00:00:00

  • Eye Tracking Reveals Abnormal Visual Preference for Geometric Images as an Early Biomarker of an Autism Spectrum Disorder Subtype Associated With Increased Symptom Severity.

    abstract:BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.03.032

    authors: Pierce K,Marinero S,Hazin R,McKenna B,Barnes CC,Malige A

    更新日期:2016-04-15 00:00:00

  • Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

    abstract:BACKGROUND:The microtubule-associated protein tau accumulates in neurodegenerative diseases known as tauopathies, the most common being Alzheimer's disease. One way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau's t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2013.02.027

    authors: Abisambra J,Jinwal UK,Miyata Y,Rogers J,Blair L,Li X,Seguin SP,Wang L,Jin Y,Bacon J,Brady S,Cockman M,Guidi C,Zhang J,Koren J,Young ZT,Atkins CA,Zhang B,Lawson LY,Weeber EJ,Brodsky JL,Gestwicki JE,Dickey CA

    更新日期:2013-09-01 00:00:00

  • Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study.

    abstract:BACKGROUND:Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrat...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2016.07.008

    authors: Carroll JE,Irwin MR,Levine M,Seeman TE,Absher D,Assimes T,Horvath S

    更新日期:2017-01-15 00:00:00

  • SOD-1 activity and platelet membrane fluidity in Alzheimer's disease.

    abstract::An early-onset, familial form of Alzheimer's disease (AD) has been reported to be linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications in the vicinity of this locus involving the beta-amyloid gene and the proto-oncogene ets-2 have been reported in association with AD. The structural ge...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90236-9

    authors: Zubenko GS,Sauer P

    更新日期:1989-03-15 00:00:00

  • Red blood cell choline. I: Choline in Alzheimer's disease.

    abstract::Seventeen drug-free patients with Alzheimer's disease (AD) and 15 normal elderly controls, of which 13 age- and sex-matched pairs were included, participated in a study of red blood cell (RBC) and plasma choline. Mean values for RBC choline, plasma choline, and the ratio of RBC/plasma choline did not differ between th...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(85)90039-3

    authors: Greenwald BS,Edasery J,Mohs RC,Shah N,Trigos GG,Davis KL

    更新日期:1985-04-01 00:00:00

  • Acute mood and thyroid stimulating hormone effects of transcranial magnetic stimulation in major depression.

    abstract:BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has recently been demonstrated to have antidepressant effects. Some work suggests that rTMS over prefrontal cortex administered to healthy individuals produces acute elevations of mood and serum thyroid-stimulating hormone (TSH). We sought to determine whet...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0006-3223(00)01118-5

    authors: Szuba MP,O'Reardon JP,Rai AS,Snyder-Kastenberg J,Amsterdam JD,Gettes DR,Wassermann E,Evans DL

    更新日期:2001-07-01 00:00:00

  • A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters.

    abstract:BACKGROUND:Venlafaxine blocks both serotonin and norepinephrine transporters (SERT and NET), with higher affinity for SERT. Serotonergic effects occur with lower doses, whereas both serotonergic and noradrenergic effects occur with higher doses of venlafaxine. Chronic treatment of rats with selective serotonin reuptake...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2005.07.011

    authors: Gould GG,Altamirano AV,Javors MA,Frazer A

    更新日期:2006-03-01 00:00:00

  • Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects.

    abstract::Plasma norepinephrine (NE), free 3-methoxy-4-hydroxyphenethylene glycol (MHPG), and binding of tritiated yohimbine to platelet membranes were measured in 14 patients with generalized anxiety disorder (GAD), who were matched for age and sex with 14 patients with unipolar major depressive disorder (MDD) and 14 normal su...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(89)90158-3

    authors: Sevy S,Papadimitriou GN,Surmont DW,Goldman S,Mendlewicz J

    更新日期:1989-01-15 00:00:00

  • Differential sex-independent amygdala response to infant crying and laughing in parents versus nonparents.

    abstract:BACKGROUND:Animal and human studies implicate forebrain neural circuits in maternal behavior. Here, we hypothesized that human brain response to emotional stimuli relevant for social interactions between infants and adults are modulated by sex- and experience-dependent factors. METHODS:We used functional magnetic reso...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(03)00697-8

    authors: Seifritz E,Esposito F,Neuhoff JG,Lüthi A,Mustovic H,Dammann G,von Bardeleben U,Radue EW,Cirillo S,Tedeschi G,Di Salle F

    更新日期:2003-12-15 00:00:00

  • Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions.

    abstract::Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审

    doi:10.1016/j.biopsych.2015.09.007

    authors: Otto MW,Kredlow MA,Smits JAJ,Hofmann SG,Tolin DF,de Kleine RA,van Minnen A,Evins AE,Pollack MH

    更新日期:2016-08-15 00:00:00

  • Lymphocyte subset, lymphocyte proliferative response, and soluble interleukin-2 receptor in anorexic patients.

    abstract:BACKGROUND:Despite a prominent malnourished state, anorexics are unexpectedly free from infection. Several studies have shown that the cell-mediated immunity of anorexics might be well preserved, but results are conflicting. METHODS:Lymphocyte subsets, lymphoproliferative response to phytohemagglutinin, and soluble in...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(98)00082-1

    authors: Nagata T,Kiriike N,Tobitani W,Kawarada Y,Matsunaga H,Yamagami S

    更新日期:1999-02-15 00:00:00

  • Body weight and reported versus measured weight loss as confounders of the dexamethasone suppression test.

    abstract::We examined the association between post-dexamethasone suppression test (DST) serum cortisol and body weight, self-report of weight loss during the episode, and measured weight loss during the first week of admission in a series of 245 depressed inpatients. Data on measured weight loss between two successive admission...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(86)90267-2

    authors: Pfohl B,Coryell W,Stangl D,Zimmerman M

    更新日期:1986-08-01 00:00:00

  • Hemispheric asymmetry of frontal and temporal gray matter and age of onset in schizophrenia.

    abstract:BACKGROUND:Investigators have reported lack of normal asymmetry of lateralization in some schizophrenic patients, as measured postmortem and by preference and/or performance. It has been suggested that this lack of asymmetry is related to early onset of schizophrenia. The present study extends the inquiry by magnetic r...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0006-3223(98)00076-6

    authors: Maher BA,Manschreck TC,Yurgelun-Todd DA,Tsuang MT

    更新日期:1998-09-15 00:00:00

  • Immunity, major depression, and panic disorder comorbidity.

    abstract::Because recent research reports indicated clinical and biological differences in major depression with and without comorbid Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) panic disorder, and as altered immune measures were reported in selected subgroups of depressive patients, we investigated 51 pai...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/0006-3223(92)90116-h

    authors: Andreoli A,Keller SE,Rabaeus M,Zaugg L,Garrone G,Taban C

    更新日期:1992-05-01 00:00:00

  • Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking.

    abstract:BACKGROUND:There is growing evidence that the dysregulation of circadian rhythms may play an important role in irregular sleep-waking in demented elderly. In this study, we investigated daily variation of the pineal hormone melatonin, which has been reported to possess hypnogenic and synchronizing effects, in patients ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/s0006-3223(97)00510-6

    authors: Mishima K,Tozawa T,Satoh K,Matsumoto Y,Hishikawa Y,Okawa M

    更新日期:1999-02-15 00:00:00

  • Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.

    abstract:BACKGROUND:Identifying the underlying cellular mechanisms of episodic memory is an important challenge, since this memory, based on temporal and contextual associations among events, undergoes preferential degradation in aging and various neuropsychiatric disorders. Memory storage of temporal and contextual association...

    journal_title:Biological psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.biopsych.2015.07.017

    authors: Potier M,Georges F,Brayda-Bruno L,Ladépêche L,Lamothe V,Al Abed AS,Groc L,Marighetto A

    更新日期:2016-05-01 00:00:00