Abstract：
BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Seventeen abstinent cocaine-dependent patients were administered the IGT after completion of resting 99mTc-HMPAO single-photon emission computed tomography (SPECT). RESULTS:Better IGT performance was negatively correlated with perfusion within the anterior cingulate gyrus, middle frontal gyrus, medial frontal gyrus, and superior frontal gyrus. The time to complete card selections was positively correlated with the severity of impairment. CONCLUSIONS:Resting hyperperfusion in brain regions previously implicated in decision making and response inhibition was associated with worse IGT scores. Impaired performance was related to a greater amount of time taken for card selections, suggesting that reduced ability was due to cognitive factors other than an impulsive response pattern.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TRdoi
10.1016/j.biopsych.2004.06.031subject
Has Abstractpub_date
2004-10-01 00:00:00pages
527-30issue
7eissn
0006-3223issn
1873-2402pii
S0006-3223(04)00709-7journal_volume
56pub_type
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