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Effects of thyrotropin-releasing hormone administration on the electroconvulsive therapy induced prolactin responses and seizure time.

Abstract：

:The effects of thyrotropin-releasing hormone (TRH) administration on electroconvulsive therapy (ECT)-induced prolactin (PRL) secretion and the duration of the seizure were studied in 14 depressed women. In a balanced order crossover design the patients were given 0.4 mg TRH or placebo intravenously 20 min before ECT during the first two sessions. In the third ECT session TRH was given just prior to ECT. ECT elicited the expected PRL response when given alone and when given 20 min after TRH when PRL plasma levels were high. During the coadministration design (third ECT session) PRL levels were raised not as a sum of the two stimuli but even significantly more. TRH failed to modify the duration of the seizure induced by ECT. Therefore, if TRH is involved in seizure modulation during ECT, our findings suggest a postictal rather than ictal role for TRH.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Papakostas Y,Markianos M,Pehlivanidis A,Papadimitriou GN,Zervas IM,Daras M,Stefanis C

doi

10.1016/0006-3223(95)00198-0

subject

Has Abstract

pub_date

1996-03-15 00:00:00

pages

444-7

issue

6

eissn

0006-3223

issn

1873-2402

pii

0006322395001980

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验

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