Abstract：
BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the disorder. At baseline functional magnetic resonance imaging (fMRI) scan, none met criteria for any psychiatric disorder, but four subjects subsequently developed schizophrenia. We report the baseline functional imaging findings in these subjects performing a sentence completion task compared with normal control subjects (n = 21) and those at high risk with (n = 21) and without (n = 41) psychotic symptoms who have not developed the disorder. RESULTS:High-risk subjects who became ill demonstrated increased activation of the parietal lobe, decreased activation of the anterior cingulate, and smaller increases in activation with increasing task difficulty in the right lingual gyrus and bilateral temporal regions. The hypothesized predictive power of parietal activation was supported only in combination with lingual gyrus activity, which gave a positive predictive value in this sample of .80. CONCLUSIONS:Although these findings should be considered cautiously, as only four subjects who had an fMRI scan subsequently became ill, they suggest functional abnormalities are present in high-risk subjects who later became ill, which distinguish them not only from normal control subjects but also those at high risk who had not developed the disorder. These differences are detectable with fMRI and may have clinical utility.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SMdoi
10.1016/j.biopsych.2005.11.013subject
Has Abstractpub_date
2006-09-01 00:00:00pages
454-62issue
5eissn
0006-3223issn
1873-2402pii
S0006-3223(05)01432-0journal_volume
60pub_type
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更新日期：2007-01-15 00:00:00
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journal_title：Biological psychiatry
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doi：
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
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