Abstract：
BACKGROUND:The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS protocols to target cortico-cortical and cortico-subcortical networks by using different intervals between the paired pulses in an attempt to modify response inhibition. METHODS:A total of 25 healthy volunteers underwent four cPAS sessions in random order 1 week apart: right inferior frontal cortex (IFC) stimulation preceding right presupplementary motor area (pre-SMA) stimulation by 10 or 4 ms and pre-SMA stimulation preceding IFC stimulation by 10 or 4 ms. Subjects were tested on the stop signal task along with the delay discounting task as control at baseline (randomized across sessions and cPAS protocol) and after each cPAS session. RESULTS:The stop signal reaction time showed a main effect of cPAS condition when controlling for age (F3,57 = 4.05, p = .01). Younger subjects had greater impairments in response inhibition when the pre-SMA pulse preceded the IFC pulse by 10 ms. In older individuals, response inhibition improved when the IFC pulse preceded the pre-SMA pulse by 4 ms. There were no effects on delay discounting. CONCLUSIONS:cPAS modified response inhibition through age-dependent long-term potentiation and depression-like plasticity mechanisms via putative cortico-cortical and cortico-subcortical networks. We show for the first time the capacity for cPAS to modify a cognitive process highly relevant to psychiatric disorders.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Kohl S,Hannah R,Rocchi L,Nord CL,Rothwell J,Voon Vdoi
10.1016/j.biopsych.2018.03.009subject
Has Abstractpub_date
2019-02-15 00:00:00pages
355-363issue
4eissn
0006-3223issn
1873-2402pii
S0006-3223(18)31405-7journal_volume
85pub_type
杂志文章abstract：:Schizophrenia is a debilitating mental illness that affects approximately 1% of the world's population. Despite much research in its neurobiology to aid in developing new treatments, little progress has been made. One system that has not received adequate attention is the kappa opioid system and its potential role in ...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2019.05.012
更新日期：2019-10-01 00:00:00
abstract：:Using auditory evoked responses, this work compares the reactivities to unimodal and crossmodal stimuli and the main neurocognitive functions most often disturbed in autism. With the aim of testing the hypothesis that the deficit in the ability to form crossmodal associations in autism is linked to a cognitive abnorma...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90338-z
更新日期：1992-06-15 00:00:00
abstract：:Previous studies have demonstrated blunted beta-adrenergic responsivity in leukocytes from depressed patients. We sought to determine if this blunted cyclic adenosine monophosphate (AMP) response is specific for beta-adrenergic receptors (homologous), or whether other adenylyl cyclase-coupled receptors are also involv...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/S0006-3223(97)00154-6
更新日期：1997-11-15 00:00:00
abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2018.05.011
更新日期：2018-12-15 00:00:00
abstract：BACKGROUND:Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone "set the stage" for relapse by promoting endocannabinoid-induced attenuati...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.09.024
更新日期：2018-07-15 00:00:00
abstract：:This overview describes the generation and development of the ideas that led to the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. It also describes the organization, process, and products of the first meeting. The CNTRICS initiative involves a series of three con...
journal_title：Biological psychiatry
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.biopsych.2008.03.020
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2014.11.014
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00346-9
更新日期：2003-11-15 00:00:00
abstract：BACKGROUND:Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ h...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.07.023
更新日期：2007-05-15 00:00:00
abstract：BACKGROUND:Although neuropsychological and neuroimaging studies of obsessive-compulsive disorder (OCD) have implicated the frontal cortex and subcortical structures in the pathophysiology of the disorder, few studies have examined cognitive function in patients with OCD on tasks validated in the assessment of frontal l...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00201-1
更新日期：1998-03-01 00:00:00
abstract：:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder pati...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90129-6
更新日期：1987-01-01 00:00:00
abstract：:It has been proposed that the nailfold subpapillary plexus visibility score (PVS) may be a marker of susceptibility to schizophrenia. To further investigate this hypothesis, we evaluated plexus visibility in a sample of 61 chronic schizophrenics, a large sample of first-episode psychotic patients and their first-degre...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90231-n
更新日期：1992-02-15 00:00:00
abstract：:Intracerebroventricular (icv) administration of corticotropin-releasing hormone (CRH) or exposure to a restraint stressor causes acute anorexia in rats. However, the effects on food intake of repeated injections of CRH or repeated exposures to restraint stress have not been previously reported. As the effects of these...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(90)90046-5
更新日期：1990-05-15 00:00:00
abstract：BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raph...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(99)00313-3
更新日期：2000-06-15 00:00:00
abstract：:To confirm and extend previous observations concerning the correlation between cell-mediated immunity and psychiatric diseases, 511 patients with schizophrenia, cerebral atrophy, dementia, and mental retardation, and 32 control subjects and 27 control patients were skin-tested with human brain S-100 protein and human ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：:Regional cerebral blood flow (rCBF) was measured with the 133Xenon clearance technique and a high resolution (254 detectors) scanner during the performance of a verbal and a facial memory task in 18 patients with schizophrenia and 18 sociodemographically matched controls. Patients and controls had comparable resting r...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)91160-6
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia. METHODS:S100B a...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.10.044
更新日期：2009-06-15 00:00:00
abstract：:Dietary administration of L-tryptophan to rats failed to increase blood platelets. Instead platelet counts were decreased after feeding either a tryptophan-deficient or tryptophan-enriched (10%) diet, but were unchanged in animals on a 1% tryptophan diet. Platelet median volumes were not affected by any of these dieta...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
abstract：:Depressive episodes as reversible mental states are likely to be associated with equally reversible brain states. These can be examined with a variety of functional imaging methods using repeated measures designs. Studies using such an approach are reviewed. Changes in medial frontal, and in particular, cingulate cort...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(95)00320-7
更新日期：1996-06-15 00:00:00
abstract：BACKGROUND:The cAMP signaling pathway, and its downstream neurotrophic factor BDNF, are major targets of antidepressant medications. Abnormalities in this pathway have previously been reported in postmortem brain of subjects with mood disorders. This study was designed to test whether the diagnosis of a mood disorder, ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(01)01083-6
更新日期：2001-08-15 00:00:00
abstract：BACKGROUND:Chronic alcohol use is associated with higher than expected rates of panic disorder. METHODS:To study the relationship between alcoholism and panic disorder, we administered the panicogenic agent, sodium lactate, to 26 alcoholics with either panic disorder or frequent panic attacks (ALCPAN), 20 nonalcoholic...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00008-5
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has been proposed as a potential tool for identifying endophenotypes relevant to mood disorders. Several studies have shown abnormal cortisol reactivity in phenotypically healthy adults without psychiatric disorders as a function of exposure to...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.02.030
更新日期：2009-07-01 00:00:00
abstract：:Psychological functions that are behaviorally and neurally well specified may serve as endophenotypes for attention-deficit/hyperactivity disorder (ADHD) research. Such endophenotypes, which lie between genes and symptoms, may relate more directly to relevant genetic variability than does the clinical ADHD syndrome it...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2004.10.026
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:In nonhuman mammals, oxytocin has a critical role in peer recognition and social approach behavior. In humans, oxytocin has been found to enhance trust and the ability to interpret the emotions of others. It has been suggested that oxytocin may enhance facial processing by increasing focus on the eye region ...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2007.06.026
更新日期：2008-01-01 00:00:00
abstract：:Accumulating evidence supports the view that deregulation of the immune system represents an important vulnerability factor for psychosis. In a subgroup of psychotic patients, the high comorbidity with autoimmune and chronic inflammatory conditions suggests a common underlying immune abnormality leading to both condit...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2013.09.037
更新日期：2014-02-15 00:00:00
abstract：BACKGROUND:Two broad treatment options exist for switching antidepressants for depressed patients who fail to respond to a selective serotonin reuptake inhibitor (SSRI): either a second course of SSRI therapy or a different class of antidepressants. The goal of the present work was to conduct a meta-analysis of studies...
journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2007.08.010
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Excitatory synaptic transmission in the nucleus accumbens (NAc) regulates the reinstatement of drug seeking, an animal model of relapse in human drug addicts. However, the functional adaptations at NAc synapses that mediate reinstatement are not clearly understood. METHODS:We assessed the behavioral respons...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.12.028
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Low doses of psychostimulants, such as methylphenidate (MPH), are widely used in the treatment of attention-deficit/hyperactivity disorder (ADHD). Surprisingly little is known about the neural mechanisms that underlie the behavioral/cognitive actions of these drugs. The prefrontal cortex (PFC) is implicated ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.04.022
更新日期：2006-11-15 00:00:00
abstract：BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00447-2
更新日期：1998-10-01 00:00:00
