The anorectic effects of CRH and restraint stress decrease with repeated exposures.

abstract：BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...

journal_title：Biological psychiatry

authors： Surguladze S,Brammer MJ,Keedwell P,Giampietro V,Young AW,Travis MJ,Williams SC,Phillips ML

更新日期：2005-02-01 00:00:00

abstract：:Male hooded rats were observed for 6 days following implantation with slow-release subcutaneous pellets containing LSD, mescaline, or control vehicle solution. In animals housed in isolation cages, continuous hallucinogen administration resulted in a gradual increase in head twitches and catatonic postures which peake...

journal_title：Biological psychiatry

authors： Ellison G,Ring M,Ross D,Axelrood B

更新日期：1980-02-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) measures of dynorphin A were compared in three groups. Alzheimer patients (n = 9), elderly depressives (n = 9), and age-matched normal controls (n = 9). The Alzheimer patients revealed a 40% decrease in CSF dynorphin compared with controls (36 +/- 15 versus 60 +/- 21 pg/ml, p less than 0.05)....

journal_title：Biological psychiatry

authors： Sunderland T,Berrettini WH,Molchan SE,Lawlor BA,Martinez RA,Vitiello B,Tariot PN,Cohen RM

更新日期：1991-07-01 00:00:00

abstract：:Neuroendocrine functions in depressed patients with major affective disorders were serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI) measurement. Prior to antidepressant therapy, the sensitivity...

journal_title：Biological psychiatry

authors： Itoh N,Matsui N,Fuwano S,Yaginuma H,Miyashita O,Sakai M

更新日期：1987-05-01 00:00:00

abstract：:This study evaluated electrophysiological (EEG, ERGs), and cognitive (neuropsychological testing) responses in patients with late luteal phase dysphoric disorder (LLPDD, DSM-III-R) and controls over the menstrual cycle. In both groups, the frequency and stability of electroencephalogram (EEG) alpha activity significan...

journal_title：Biological psychiatry

authors： Ehlers CL,Phillips E,Parry BL

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to ge...

journal_title：Biological psychiatry

authors： Fornito A,Yoon J,Zalesky A,Bullmore ET,Carter CS

更新日期：2011-07-01 00:00:00

abstract：:Cell lines of continuously dividing human olfactory neuroblasts can be propagated using olfactory epithelium obtained from human donors at biopsy or autopsy. The expression of neuronal proteins in these cells, such as neurofilament protein and tau protein, can be increased using a combination of factors including nerv...

journal_title：Biological psychiatry

authors： Wolozin B,Lesch P,Lebovics R,Sunderland T

更新日期：1993-12-15 00:00:00

abstract：BACKGROUND:Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging. METHODS:Given that scalp hair follicles are easily accessible and, like the brain, are derived from the ectoderm, expressions of messenger RNA (mRNA) and microRNA in the organ were examined between schizoph...

journal_title：Biological psychiatry

authors： Maekawa M,Yamada K,Toyoshima M,Ohnishi T,Iwayama Y,Shimamoto C,Toyota T,Nozaki Y,Balan S,Matsuzaki H,Iwata Y,Suzuki K,Miyashita M,Kikuchi M,Kato M,Okada Y,Akamatsu W,Mori N,Owada Y,Itokawa M,Okano H,Yoshikawa T

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

journal_title：Biological psychiatry

authors： Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Cognitive abnormalities are increasingly recognized as a feature of bipolar I disorder (BDI,) but there is limited information regarding the pattern and severity of cognitive impairment during remission and its relationship with clinical variables. METHODS:Forty-four remitted BDI patients recruited from a r...

journal_title：Biological psychiatry

authors： Frangou S,Donaldson S,Hadjulis M,Landau S,Goldstein LH

更新日期：2005-12-01 00:00:00

abstract：:Velocity of blood flow in the middle cerebral artery was measured with transcranial Doppler flowmeter before, during, and 1 hr after smoking a marijuana cigarette and a placebo cigarette during two separate visits to the laboratory. Ten healthy, right-handed male volunteers with a history of marijuana smoking took par...

journal_title：Biological psychiatry

authors： Mathew RJ,Wilson WH,Humphreys DF,Lowe JV,Wiethe KE

更新日期：1992-07-15 00:00:00

abstract：BACKGROUND:Neuronal activity at gamma frequency is impaired in schizophrenia (SZ) and is considered critical for cognitive performance. Such impairments are thought to be due to reduced N-methyl-D-aspartate receptor (NMDAR)-mediated inhibition from parvalbumin interneurons, rather than a direct role of impaired NMDAR s...

journal_title：Biological psychiatry

authors： Tatard-Leitman VM,Jutzeler CR,Suh J,Saunders JA,Billingslea EN,Morita S,White R,Featherstone RE,Ray R,Ortinski PI,Banerjee A,Gandal MJ,Lin R,Alexandrescu A,Liang Y,Gur RE,Borgmann-Winter KE,Carlson GC,Hahn CG,Siegel

更新日期：2015-03-15 00:00:00

abstract：BACKGROUND:Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychoti...

journal_title：Biological psychiatry

authors： Bojesen KB,Broberg BV,Fagerlund B,Jessen K,Thomas MB,Sigvard A,Tangmose K,Nielsen MØ,Andersen GS,Larsson HBW,Edden RAE,Rostrup E,Glenthøj BY

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...

journal_title：Biological psychiatry

authors： Tozzi A,de Iure A,Bagetta V,Tantucci M,Durante V,Quiroga-Varela A,Costa C,Di Filippo M,Ghiglieri V,Latagliata EC,Wegrzynowicz M,Decressac M,Giampà C,Dalley JW,Xia J,Gardoni F,Mellone M,El-Agnaf OM,Ardah MT,Puglisi-A

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Norepinephrine and dopamine mediate important aspects of alcoholism and alcohol withdrawal. Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the struc...

journal_title：Biological psychiatry

authors： Köhnke MD,Zabetian CP,Anderson GM,Kolb W,Gaertner I,Buchkremer G,Vonthein R,Schick S,Lutz U,Köhnke AM,Cubells JF

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator...

journal_title：Biological psychiatry

authors： Williams NM,Preece A,Spurlock G,Norton N,Williams HJ,McCreadie RG,Buckland P,Sharkey V,Chowdari KV,Zammit S,Nimgaonkar V,Kirov G,Owen MJ,O'Donovan MC

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Although neuropsychological and neuroimaging studies of obsessive-compulsive disorder (OCD) have implicated the frontal cortex and subcortical structures in the pathophysiology of the disorder, few studies have examined cognitive function in patients with OCD on tasks validated in the assessment of frontal l...

journal_title：Biological psychiatry

authors： Purcell R,Maruff P,Kyrios M,Pantelis C

更新日期：1998-03-01 00:00:00

abstract：:Abnormalities in circadian rhythms of core body temperature have been reported previously in depressed patients. In this study, we compared the temperature rhythms of 10 depressed seasonal affective disorder (SAD) patients with winter depression with those of 12 normal controls and evaluated the effects of bright ligh...

journal_title：Biological psychiatry

authors： Rosenthal NE,Levendosky AA,Skwerer RG,Joseph-Vanderpool JR,Kelly KA,Hardin T,Kasper S,DellaBella P,Wehr TA

更新日期：1990-01-01 00:00:00

abstract：:The regional distribution of iron, copper, zinc, magnesium, and calcium in postmortem brain of schizophrenic patients was compared with that of matched controls. In none of the brain regions investigated (caudate nucleus, hippocampus, amygdala, cortex, corpus mamillare, gyrus cinguli, and hypothalamus) were significan...

journal_title：Biological psychiatry

authors： Kornhuber J,Lange KW,Kruzik P,Rausch WD,Gabriel E,Jellinger K,Riederer P

更新日期：1994-07-01 00:00:00

abstract：:Twenty-eight psychiatric patients with computerized tomography (CT) findings of ventricular abnormality most likely to result from prenatal/perinatal lesions (VA group) were compared to 28 sex- and age-matched psychiatric patients with normal neuroradiological findings (NCT group). The neuroradiological rater was blin...

journal_title：Biological psychiatry

authors： Franzek E,Becker T,Hofmann E,Flöhl W,Stöber G,Beckmann H

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:Several studies have reported elevated S100B serum levels in schizophrenia. Our study focused on its scavenger, soluble receptor for advanced glycation end products (sRAGE). Given the benefits of sRAGE in metabolic and inflammatory diseases, we hypothesized a similar effect in schizophrenia. METHODS:S100B a...

journal_title：Biological psychiatry

authors： Steiner J,Walter M,Wunderlich MT,Bernstein HG,Panteli B,Brauner M,Jacobs R,Gos T,Rothermundt M,Bogerts B

更新日期：2009-06-15 00:00:00

abstract：BACKGROUND:Transcranial magnetic stimulation is a novel, experimental procedure in the treatment of psychiatric disorders, most notably mood disorders. Transcranial magnetic stimulation is currently being widely studied in other applications, and its efficacies and potential side effects are being investigated. METHOD...

journal_title：Biological psychiatry

authors： Dolberg OT,Schreiber S,Grunhaus L

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

journal_title：Biological psychiatry

authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Structural MRI data indicate schizophrenics have reduced left-sided temporal lobe gray matter volumes, especially in the superior temporal gyrus (STG) and medial temporal lobe. Our data further suggest a specificity to schizophrenia spectrum disorders of STG volume reduction. Interpretation of research studi...

journal_title：Biological psychiatry

authors： Dickey CC,McCarley RW,Voglmaier MM,Niznikiewicz MA,Seidman LJ,Hirayasu Y,Fischer I,Teh EK,Van Rhoads R,Jakab M,Kikinis R,Jolesz FA,Shenton ME

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The observation that some patients with schizophrenia display subtly anomalous craniofacial features dates back to the early 1900s and has recently been hypothesized to reflect disrupted prenatal development also involving the brain. Most studies to date have used observer ratings rather than physical measur...

journal_title：Biological psychiatry

authors： Donovan-Lepore AM,Jaeger J,Czobor P,Abdelmessih S,Berns SM

更新日期：2006-02-15 00:00:00

abstract：BACKGROUND:Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels...

journal_title：Biological psychiatry

authors： Rosenberg DR,Benazon NR,Gilbert A,Sullivan A,Moore GJ

更新日期：2000-08-15 00:00:00

abstract：:Dysfunction of the central serotonergic system has been associated with depression in Parkinson's disease. To evaluate central serotonergic function in Parkinson's disease in relation to depression, we examined prolactin and cortisol responses to a single-dose challenge with fenfluramine (60 mg orally), a serotonin re...

journal_title：Biological psychiatry

authors： Kostić VS,Lecić D,Doder M,Marinković J,Filipović S

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:Brain imaging research in posttraumatic stress disorder has been largely performed on patients with chronic disease, often heavily medicated, with current or past alcohol and substance abuse. Additionally, virtually only activation brain imaging paradigms have been done in posttraumatic stress disorder, wher...

journal_title：Biological psychiatry

authors： Bonne O,Gilboa A,Louzoun Y,Brandes D,Yona I,Lester H,Barkai G,Freedman N,Chisin R,Shalev AY

更新日期：2003-11-15 00:00:00

abstract：:Functional neuroimaging studies have identified multiple nodes of dysfunction in frontostriatal and mesocorticolimbic networks in attention-deficit/hyperactivity disorder (ADHD). Yet relatively few studies have examined how structural and functional connectivity between nodes in these networks might relate to the beha...

journal_title：Biological psychiatry

authors： Liston C,Malter Cohen M,Teslovich T,Levenson D,Casey BJ

更新日期：2011-06-15 00:00:00

abstract：BACKGROUND:Survival and differentiation of neurons and the formation and maintenance of synapses in the cerebral cortex may be affected in schizophrenia. Since neurotrophins play an important role in these events, behavioral effects relevant to schizophrenia were investigated in rats that had compromised neurotrophin f...

journal_title：Biological psychiatry

authors： Rajakumar N,Leung LS,Ma J,Rajakumar B,Rushlow W

更新日期：2004-04-15 00:00:00