Abstract：
BACKGROUND:The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples. METHODS:We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18. RESULTS:We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4. CONCLUSIONS:Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Williams NM,Preece A,Spurlock G,Norton N,Williams HJ,McCreadie RG,Buckland P,Sharkey V,Chowdari KV,Zammit S,Nimgaonkar V,Kirov G,Owen MJ,O'Donovan MCdoi
10.1016/j.biopsych.2003.11.002subject
Has Abstractpub_date
2004-01-15 00:00:00pages
192-5issue
2eissn
0006-3223issn
1873-2402pii
S0006322303011697journal_volume
55pub_type
杂志文章abstract：BACKGROUND:Several studies have found that alpha-tocopherol (vitamin E) can effectively treat tardive dyskinesia (TD). A limitation of these trials is their short treatment durations (maximum of 12 weeks), which do not allow us to address the effects of long-term treatment. METHODS:To participate, patients had to have...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
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doi：
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