Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.

abstract：BACKGROUND:Excitatory synaptic transmission in the nucleus accumbens (NAc) regulates the reinstatement of drug seeking, an animal model of relapse in human drug addicts. However, the functional adaptations at NAc synapses that mediate reinstatement are not clearly understood. METHODS:We assessed the behavioral respons...

journal_title：Biological psychiatry

authors： Rothwell PE,Kourrich S,Thomas MJ

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...

journal_title：Biological psychiatry

authors： Joffe H,Cohen LS,Suppes T,Hwang CH,Molay F,Adams JM,Sachs GS,Hall JE

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:The magnitude of the startle eyeblink response is reduced if the startle eliciting stimulus is shortly preceded by another stimulus. There is evidence that schizophrenia patients exhibit impairments in this so-called prepulse inhibition. Our study investigated whether prepulse inhibition is affected by neuro...

journal_title：Biological psychiatry

authors： Weike AI,Bauer U,Hamm AO

更新日期：2000-01-01 00:00:00

abstract：:Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency ...

journal_title：Biological psychiatry

authors： Mendelson WB,Reichman J,Othmer E

更新日期：1975-08-01 00:00:00

abstract：:Children who experience chronic stressors are vulnerable to emotional and physical health problems across the lifespan. This phenomenon raises questions for scientists and clinicians alike. How does adversity get under the skin of the developing child? Through what mechanisms does it confer vulnerability to a heteroge...

journal_title：Biological psychiatry

authors： Nusslock R,Miller GE

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:As observed in depressed adults, there is considerable variability in the degree and direction of hypothalamic-pituitary-adrenal (HPA) dysfunction in depressed adolescents. The variability in HPA findings may be attributed to experiential factors. METHODS:A modified version of a standard psychosocial stress...

journal_title：Biological psychiatry

authors： Rao U,Hammen C,Ortiz LR,Chen LA,Poland RE

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients. METHODS:Saccadic eye movements were examined in 21 women with and 21 women witho...

journal_title：Biological psychiatry

authors： Sundström I,Bäckström T

更新日期：1998-10-15 00:00:00

abstract：BACKGROUND:In schizophrenia (SZ), disturbances in integration of activity among brain regions seem to be as important as abnormal activity of any single region. Brain regions are connected through white matter (WM) tracts, and diffusion tensor imaging has provided compelling evidence for WM abnormalities in SZ. However...

journal_title：Biological psychiatry

authors： Du F,Cooper AJ,Thida T,Shinn AK,Cohen BM,Ongür D

更新日期：2013-09-15 00:00:00

abstract：:Twenty-eight psychiatric patients with computerized tomography (CT) findings of ventricular abnormality most likely to result from prenatal/perinatal lesions (VA group) were compared to 28 sex- and age-matched psychiatric patients with normal neuroradiological findings (NCT group). The neuroradiological rater was blin...

journal_title：Biological psychiatry

authors： Franzek E,Becker T,Hofmann E,Flöhl W,Stöber G,Beckmann H

更新日期：1996-12-15 00:00:00

abstract：:Several studies have reported prolonged neural transmission times on auditory brainstem responses (ABRs) measured in autistic children, a finding which implicates CNS dysfunction at the level of the brainstem in autistic conditions. This study measured ABRs in 25 children and adults with pervasive developmental disord...

journal_title：Biological psychiatry

authors： Rumsey JM,Grimes AM,Pikus AM,Duara R,Ismond DR

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Many polymorphisms in dopamine genes are reported to affect cognitive, imaging, or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product itself. However, the supporting evidence is not always clear. METHODS...

journal_title：Biological psychiatry

authors： Tunbridge EM,Narajos M,Harrison CH,Beresford C,Cipriani A,Harrison PJ

更新日期：2019-10-15 00:00:00

abstract：:Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective I...

journal_title：Biological psychiatry

authors： Kirch DG,Kaufmann CA,Papadopoulos NM,Martin B,Weinberger DR

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI). METHODS:Ten subjects with current OCD and 10 healthy control subjects underwent fMRI, during which they viewed pictures of fearful, happy, and neutral human faces, as...

journal_title：Biological psychiatry

authors： Cannistraro PA,Wright CI,Wedig MM,Martis B,Shin LM,Wilhelm S,Rauch SL

更新日期：2004-12-15 00:00:00

abstract：:There is indirect evidence that smoking induces higher enzymatic activity which accelerates the metabolism of many drugs. This influence is inferred from the frequency and magnitude of drug side effects. We could demonstrate that smokers need higher doses of neuroleptic drugs than nonsmokers. ...

journal_title：Biological psychiatry

authors： Vinarová E,Vinar O,Kalvach Z

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychoti...

journal_title：Biological psychiatry

authors： Bojesen KB,Broberg BV,Fagerlund B,Jessen K,Thomas MB,Sigvard A,Tangmose K,Nielsen MØ,Andersen GS,Larsson HBW,Edden RAE,Rostrup E,Glenthøj BY

更新日期：2021-02-01 00:00:00

abstract：:Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and from 22 age- and sex-matched healthy controls were assessed for the activity of the agonist-stimulated inositol-phospholipid second messenger-producing system. [3H]inositol-labeled cells were stimulated with the chemotactic peptide formy...

journal_title：Biological psychiatry

authors： Greil W,Steber R,van Calker D

更新日期：1991-09-01 00:00:00

abstract：:Potential recovery of electrophysiological and neuropsychological functions was investigated in alcoholics completing treatment and controls. Event-related potentials (ERPs) and neuropsychological tests were administered initially and repeated 14 months later. Alcoholics were classified as resumers or abstainers based...

journal_title：Biological psychiatry

authors： Glenn S,Parsons OA,Sinha R

更新日期：1994-10-01 00:00:00

abstract：:Cocaine can cause a variety of neuropsychiatric and neurobehavioral complications; however, it is uncertain whether cocaine causes persistent cerebral structural and neurochemical abnormalities in asymptomatic users. We studied 52 African-American men (26 human immunodeficiency virus-negative asymptomatic heavy cocain...

journal_title：Biological psychiatry

authors： Chang L,Mehringer CM,Ernst T,Melchor R,Myers H,Forney D,Satz P

更新日期：1997-12-15 00:00:00

abstract：BACKGROUND:Recent research has demonstrated that clinical depression can emerge as early as the preschool period. Here, we examine brain function in children with a history of preschool-onset depression (PO-MDD) in comparison with healthy children. METHODS:Participants were medication naïve school-aged children (ages ...

journal_title：Biological psychiatry

authors： Barch DM,Gaffrey MS,Botteron KN,Belden AC,Luby JL

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Regional brain perfusion in patients during alcohol-withdrawal has been relatively less studied with brain SPECT technique. In this study, the hypothesis that possible regional cerebral blood flow (rCBF) alterations due to alcohol withdrawal might be transitory in a homogenous group of alcoholic patients in ...

journal_title：Biological psychiatry

authors： Tutus A,Kuğu N,Sofuoğlu S,Nardali M,Simşek A,Karaaslan F,Gönül AS

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. METHODS:We selected 120 SNPs covering 1 Mb around D1S251 from the public database....

journal_title：Biological psychiatry

authors： Liu YL,Fann CS,Liu CM,Chen WJ,Wu JY,Hung SI,Chen CH,Jou YS,Liu SK,Hwang TJ,Hsieh MH,Ouyang WC,Chan HY,Chen JJ,Yang WC,Lin CY,Lee SF,Hwu HG

更新日期：2006-09-15 00:00:00

abstract：BACKGROUND:Myotonic dystrophy (DM) is a genetic multisystemic disease with muscular, endocrine, ocular, cardiac and cognitive impairment. The molecular basis of the disease has been identified in an unstable base triplet (CTG)n repeat located in the 3' untranslated region of the miotonin protein-kinase (MT-PK) gene on ...

journal_title：Biological psychiatry

authors： Perini GI,Menegazzo E,Ermani M,Zara M,Gemma A,Ferruzza E,Gennarelli M,Angelini C

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

journal_title：Biological psychiatry

authors： Wohleb ES,Terwilliger R,Duman CH,Duman RS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Experimental animal studies suggest that early glucocorticoid exposure may have lasting effects on the neurodevelopment of the offspring; animal studies also suggest that this effect may be eliminated by positive postnatal rearing. The relevance of these findings to humans is not known. METHODS:We prospecti...

journal_title：Biological psychiatry

authors： Bergman K,Sarkar P,Glover V,O'Connor TG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) has recently been demonstrated to have antidepressant effects. Some work suggests that rTMS over prefrontal cortex administered to healthy individuals produces acute elevations of mood and serum thyroid-stimulating hormone (TSH). We sought to determine whet...

journal_title：Biological psychiatry

authors： Szuba MP,O'Reardon JP,Rai AS,Snyder-Kastenberg J,Amsterdam JD,Gettes DR,Wassermann E,Evans DL

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:This multicenter, randomized, fixed-dose, double-blind, placebo-controlled study evaluated efficacy of extended-release dexmethylphenidate (d-MPH-ER) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS:Randomized adults with ADHD (n=221) received once-daily d-MPH-ER 20 mg, 30 mg, or 40 m...

journal_title：Biological psychiatry

authors： Spencer TJ,Adler LA,McGough JJ,Muniz R,Jiang H,Pestreich L,Adult ADHD Research Group.

更新日期：2007-06-15 00:00:00

abstract：BACKGROUND:Monoamine dysfunction, particularly of the serotonin system, has been the dominant hypothesis guiding research and treatment development in affective disorders. The majority of research has been performed in midlife depressed adults. The importance of understanding the neurobiology of depression in older adu...

journal_title：Biological psychiatry

authors： Smith GS,Kramer E,Hermann C,Ma Y,Dhawan V,Chaly T,Eidelberg D

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic re...

journal_title：Biological psychiatry

authors： Wong CG,Stevens MC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood. Chronic stress may induce recalibrations in mitochondria leading to changes either in mitochondrial content per cell, or in mitochondrial functional capacity (i....

journal_title：Biological psychiatry

authors： Picard M,Prather AA,Puterman E,Cuillerier A,Coccia M,Aschbacher K,Burelle Y,Epel ES

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Bipolar disorder is associated with functional and structural abnormalities in the brain circuits involved in processing emotional stimuli. Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emoti...

journal_title：Biological psychiatry

authors： Harmer CJ,Grayson L,Goodwin GM

更新日期：2002-02-15 00:00:00