Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.

abstract：BACKGROUND:Pharmacological evidence support that enhancement of serotonin (5-HT) neurotransmission is critical for treatment efficacy in obsessive-compulsive disorder (OCD). Surprisingly, acute tryptophan depletion (ATD), a procedure known to reduce 5-HT neurotransmission, carried out in remitted OCD patients on select...

journal_title：Biological psychiatry

authors： Berney A,Sookman D,Leyton M,Young SN,Benkelfat C

更新日期：2006-05-01 00:00:00

abstract：:Auditory event-related potentials (ERPs) associated with selective attention were recorded in 21 children at high-risk for schizophrenia and in 21 matched controls. The subjects performed a selective listening task. For behavioral evaluation, target counts on the selective listening task and on cognitive performance w...

journal_title：Biological psychiatry

authors： Schreiber H,Stolz-Born G,Kornhuber HH,Born J

更新日期：1992-10-15 00:00:00

abstract：BACKGROUND:Problems with the voluntary control of behavior, such as those leading to increased antisaccade errors, are accepted as evidence of prefrontal dysfunction in schizophrenia. We previously reported that speeded prosaccade responses, i.e., shorter response latencies for automatic shifts of attention to visual t...

journal_title：Biological psychiatry

authors： Reilly JL,Harris MS,Khine TT,Keshavan MS,Sweeney JA

更新日期：2008-04-15 00:00:00

abstract：BACKGROUND:Suicide is a major risk for those with bipolar disorder, a risk amplified by comorbid substance abuse in some, but not all, previous studies. To further explore the relationships of substance abuse, suicide, and bipolarity as they present in clinical practice, we analyzed standardized clinical data from a la...

journal_title：Biological psychiatry

authors： Comtois KA,Russo JE,Roy-Byrne P,Ries RK

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this a...

journal_title：Biological psychiatry

authors： Galera C,Barbosa S,Collet O,Khalfallah O,Aouizerate B,Sutter-Dalley AL,Koehl M,Capuron L,Van der Waerden J,Melchior M,Côté S,Heude B,Glaichenhaus N,Davidovic L,EDEN Mother–Child Cohort Study Group.

更新日期：2020-10-24 00:00:00

abstract：BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

journal_title：Biological psychiatry

authors： Wohleb ES,Terwilliger R,Duman CH,Duman RS

更新日期：2018-01-01 00:00:00

abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

journal_title：Biological psychiatry

authors： Falkai P,Bogerts B,Rozumek M

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The cystine-glutamate exchanger is downregulated after chronic cocaine, resulting in reduced extracellular levels of nucleus accumbens glutamate. The importance of cocaine-induced loss of glutamate homeostasis is revealed by N-acetylcysteine restoring cystine-glutamate exchange and attenuating reinstatement ...

journal_title：Biological psychiatry

authors： Knackstedt LA,Melendez RI,Kalivas PW

更新日期：2010-01-01 00:00:00

abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...

journal_title：Biological psychiatry

authors： Pitchot W,Ansseau M,Gonzalez Moreno A,Hansenne M,von Frenckell R

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performan...

journal_title：Biological psychiatry

authors： Bilder RM,Volavka J,Czobor P,Malhotra AK,Kennedy JL,Ni X,Goldman RS,Hoptman MJ,Sheitman B,Lindenmayer JP,Citrome L,McEvoy JP,Kunz M,Chakos M,Cooper TB,Lieberman JA

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Ovarian steroids modulate anxiety behavior, perhaps by regulating the serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform of rat tryptophan hydroxylase (TPH2) by ovarian hormones has not yet been investigated. Therefore, we examined the effects of estrogen and pro...

journal_title：Biological psychiatry

authors： Hiroi R,McDevitt RA,Neumaier JF

更新日期：2006-08-01 00:00:00

abstract：:The effects of naltrexone on both mood and cognition were examined in overweight male subjects. Subjects were randomly prescribed, in a double-blind fashion, either placebo or naltrexone for 8 weeks. The results of the study showed that a chronic administration of a high dose of naltrexone (300 mg/day) does not signif...

journal_title：Biological psychiatry

authors： Hatsukami DK,Mitchell JE,Morley JE,Morgan SF,Levine AS

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients. METHODS:Saccadic eye movements were examined in 21 women with and 21 women witho...

journal_title：Biological psychiatry

authors： Sundström I,Bäckström T

更新日期：1998-10-15 00:00:00

abstract：:Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...

journal_title：Biological psychiatry

authors： Catalano M,Nobile M,Novelli E,Nöthen MM,Smeraldi E

更新日期：1993-10-01 00:00:00

abstract：:There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging studies reporting structural and functional neural correlates of STBs and NSSI in ...

journal_title：Biological psychiatry

authors： Auerbach RP,Pagliaccio D,Allison GO,Alqueza KL,Alonso MF

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Several studies have found that alpha-tocopherol (vitamin E) can effectively treat tardive dyskinesia (TD). A limitation of these trials is their short treatment durations (maximum of 12 weeks), which do not allow us to address the effects of long-term treatment. METHODS:To participate, patients had to have...

journal_title：Biological psychiatry

authors： Adler LA,Edson R,Lavori P,Peselow E,Duncan E,Rosenthal M,Rotrosen J

更新日期：1998-06-15 00:00:00

abstract：:The history of psychiatric research is filled with widely accepted etiologic and pathophysiologic theories that eventually were proven wrong. The prevailing pathophysiologic theories of schizophrenia have emphasized the role of abnormal neurodevelopment in determining the onset and course of the illness. Relatively li...

journal_title：Biological psychiatry

authors： Lieberman JA

更新日期：1999-09-15 00:00:00

abstract：BACKGROUND:Neurons in the basal ganglia are connected to areas of prefrontal cerebral cortex involved in higher cognitive functions, and these connections occur primarily via the thalamus. In patients with bipolar disorder, regardless of age, neuroimaging studies have consistently reported an increased number of white ...

journal_title：Biological psychiatry

authors： Haznedar MM,Roversi F,Pallanti S,Baldini-Rossi N,Schnur DB,Licalzi EM,Tang C,Hof PR,Hollander E,Buchsbaum MS

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Acute ketamine has been shown to model features of schizophrenia such as psychotic symptoms, cognitive deficits and smooth pursuit eye movement dysfunction. There have been suggestions that chronic ketamine may also produce an analogue of the disorder. In this study, we investigated the effect of persistent ...

journal_title：Biological psychiatry

authors： Morgan CJ,Huddy V,Lipton M,Curran HV,Joyce EM

更新日期：2009-06-15 00:00:00

abstract：:Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...

journal_title：Biological psychiatry

authors： Detera-Wadleigh SD,McMahon FJ

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Substantial evidence indicates that alcoholism is biologically mediated by a genetic predisposition. As the decreased P300 (P3b) event-related brain potential component does not recover with prolonged abstinence, it is unlikely to be related to drinking history but is more likely to be genetically influenced...

journal_title：Biological psychiatry

authors： Hada M,Porjesz B,Chorlian DB,Begleiter H,Polich J

更新日期：2001-04-15 00:00:00

abstract：:We studied 10 subjects each with melancholic depression evidencing significant motor retardation (RM), Parkinson's disease (PD) with bradykinesia, and normal healthy controls (NC), matched closely for age and gender, on measurements of motor function and depression, and their performance of simple and complex ballisti...

journal_title：Biological psychiatry

authors： Sachdev P,Aniss AM

更新日期：1994-02-15 00:00:00

abstract：:Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and ...

journal_title：Biological psychiatry

authors： Hallmayer J,Maier W,Ackenheil M,Ertl MA,Schmidt S,Minges J,Lichtermann D,Wildenauer D

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS:Ten patients with treatment-resistant depression had r...

journal_title：Biological psychiatry

authors： Sanacora G,Kendell SF,Levin Y,Simen AA,Fenton LR,Coric V,Krystal JH

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Generalized social phobia (gSP), also known as generalized social anxiety disorder, is characterized by excessive fear of scrutiny by others and pervasive avoidance of social interactions. Pathophysiologic models of gSP implicate exaggerated reactivity of the amygdala and insula in response to social evaluat...

journal_title：Biological psychiatry

authors： Phan KL,Coccaro EF,Angstadt M,Kreger KJ,Mayberg HS,Liberzon I,Stein MB

更新日期：2013-02-15 00:00:00

abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...

journal_title：Biological psychiatry

authors： Southwick S,Mason JW,Giller EL,Kosten TR

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...

journal_title：Biological psychiatry

authors： Joffe H,Cohen LS,Suppes T,Hwang CH,Molay F,Adams JM,Sachs GS,Hall JE

更新日期：2006-12-15 00:00:00

abstract：BACKGROUND:The high rate of comorbidity between depression and cocaine addiction suggests shared molecular mechanisms and anatomical pathways. Limbic structures, such as the nucleus accumbens (NAc), play a crucial role in both disorders, yet how different cell types within these structures contribute to the pathogenesi...

journal_title：Biological psychiatry

authors： Arango-Lievano M,Schwarz JT,Vernov M,Wilkinson MB,Bradbury K,Feliz A,Marongiu R,Gelfand Y,Warner-Schmidt J,Nestler EJ,Greengard P,Russo SJ,Kaplitt MG

更新日期：2014-11-15 00:00:00

abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

journal_title：Biological psychiatry

authors： Rittmannsberger H,Leblhuber F

更新日期：1992-08-15 00:00:00

abstract：BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

journal_title：Biological psychiatry

authors： Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

更新日期：2020-08-01 00:00:00