Abstract:
BACKGROUND:The marker D1S251 of chromosome 1q42.1 showed significant association with schizophrenia in a Taiwanese sample. We used single nucleotide polymorphism (SNP) fine mapping to search for the vulnerability genes of schizophrenia. METHODS:We selected 120 SNPs covering 1 Mb around D1S251 from the public database. These selected SNPs were initially validated if allele frequency was >10%. Forty-seven validated SNPs were genotyped in 102 families with at least 2 siblings affected with schizophrenia. RESULTS:Two SNP blocks showed significant association with schizophrenia. Block 1 (five-SNP), located between intron 2 and intron 13 of the glyceronephosphate O-acyltransferase (GNPAT) gene, showed the most significant associations using single-locus TDT (z = -2.07, p = .038, df = 1) and haplotype association analyses (z = -1.99, p = .046, df = 1). Block 2 (two-SNP), located between intron 4 and intron 5 of the disrupted-in-schizophrenia 1 (DISC1) gene, also showed the most significant results in both the single-locus (z = -3.22, p = .0013, df = 1) and haplotype association analyses (z = 3.35, p = .0008, df = 1). The association of the DISC1 gene with schizophrenia was mainly in the patient group with sustained attention deficits as assessed by the Continuous Performance Test. CONCLUSIONS:Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia, and DISC1 is associated with sustained attention deficits.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Liu YL,Fann CS,Liu CM,Chen WJ,Wu JY,Hung SI,Chen CH,Jou YS,Liu SK,Hwang TJ,Hsieh MH,Ouyang WC,Chan HY,Chen JJ,Yang WC,Lin CY,Lee SF,Hwu HGdoi
10.1016/j.biopsych.2006.04.024subject
Has Abstractpub_date
2006-09-15 00:00:00pages
554-62issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(06)00535-Xjournal_volume
60pub_type
杂志文章abstract::Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
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更新日期:2009-11-01 00:00:00
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journal_title:Biological psychiatry
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doi:
更新日期:1984-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Biological psychiatry
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doi:10.1016/s0006-3223(99)00032-3
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.10.038
更新日期:2005-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00522-2
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1998-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:2005-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90163-g
更新日期:1991-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90077-q
更新日期:1993-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00308-4
更新日期:1999-07-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.10.008
更新日期:2008-05-01 00:00:00